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Buprenex
Overview
What is Buprenex?
BUPRENEX (buprenorphine hydrochloride) is a partial opioid agonist.
The chemical name of buprenorphine hydrochloride is 17-(cyclopropylmethyl)-α-(1, 1-dimethylethyl)-4, 5-epoxy-18, 19-dihydro-3-hydroxy-6-methoxy-α-methyl-6, 14-ethenomorphinan-7-methanol, hydrochloride [5α, 7α(S)].
Buprenorphine hydrochloride is a white powder, weakly acidic and with limited solubility in water.
BUPRENEX is a clear, sterile, injectable agonist-antagonist analgesic intended for intravenous or intramuscular administration. Each ml of BUPRENEX contains 0.324 mg buprenorphine hydrochloride (equivalent to 0.3 mg buprenorphine), 50 mg dextrose (as monohydrate), water for injection and HCI to adjust pH.
Buprenorphine hydrochloride has the molecular formula, CHNOHCl, and the following structure:
What does Buprenex look like?



What are the available doses of Buprenex?
Sorry No records found.
What should I talk to my health care provider before I take Buprenex?
Sorry No records found
How should I use Buprenex?
BUPRENEX is indicated for the management of pain severe enough to require an opioid analgesic and for which alternate treatments are inadequate.
Use the lowest effective dosage for the shortest duration consistent with individual patients treatment goals
Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse
Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with BUPRENEX and adjust the dosage accordingly
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What interacts with Buprenex?
Sorry No Records found
What are the warnings of Buprenex?
Sorry No Records found
What are the precautions of Buprenex?
Sorry No Records found
What are the side effects of Buprenex?
Sorry No records found
What should I look out for while using Buprenex?
BUPRENEX is contraindicated in patients with:
What might happen if I take too much Buprenex?
How should I store and handle Buprenex?
BUPRENEX (buprenorphine hydrochloride) is supplied in cartons containing five clear glass snap-ampules of 0.3 mg/mL buprenorphine). NDCStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [USP Controlled Room Temperature]. Protect from prolonged exposure to light. Manufactured by: Reckitt Benckiser Healthcare (UK) Ltd., Indivior Inc., BUPRENEX (buprenorphine hydrochloride) is supplied in cartons containing five clear glass snap-ampules of 0.3 mg/mL buprenorphine). NDCStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [USP Controlled Room Temperature]. Protect from prolonged exposure to light. Manufactured by: Reckitt Benckiser Healthcare (UK) Ltd., Indivior Inc., BUPRENEX (buprenorphine hydrochloride) is supplied in cartons containing five clear glass snap-ampules of 0.3 mg/mL buprenorphine). NDCStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [USP Controlled Room Temperature]. Protect from prolonged exposure to light. Manufactured by: Reckitt Benckiser Healthcare (UK) Ltd., Indivior Inc., BUPRENEX (buprenorphine hydrochloride) is supplied in cartons containing five clear glass snap-ampules of 0.3 mg/mL buprenorphine). NDCStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [USP Controlled Room Temperature]. Protect from prolonged exposure to light. Manufactured by: Reckitt Benckiser Healthcare (UK) Ltd., Indivior Inc., BUPRENEX (buprenorphine hydrochloride) is supplied in cartons containing five clear glass snap-ampules of 0.3 mg/mL buprenorphine). NDCStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [USP Controlled Room Temperature]. Protect from prolonged exposure to light. Manufactured by: Reckitt Benckiser Healthcare (UK) Ltd., Indivior Inc., BUPRENEX (buprenorphine hydrochloride) is supplied in cartons containing five clear glass snap-ampules of 0.3 mg/mL buprenorphine). NDCStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [USP Controlled Room Temperature]. Protect from prolonged exposure to light. Manufactured by: Reckitt Benckiser Healthcare (UK) Ltd., Indivior Inc.,
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. One unusual property of Buprenex observed in studies is its very slow rate of dissociation from its receptor. This could account for its longer duration of action than morphine, the unpredictability of its reversal by opioid antagonists, and its low level of manifest physical dependence.
Non-Clinical Toxicology
BUPRENEX is contraindicated in patients with:General:
Because BUPRENEX is metabolized by the liver, the activity of BUPRENEX may be increased and/or extended in those individuals with impaired hepatic function or those receiving other agents known to decrease hepatic clearance.
BUPRENEX has been shown to increase intracholedochal pressure to a similar degree as other opioid analgesics, and thus should be administered with caution to patients with dysfunction of the biliary tract.
The most frequent side effect in clinical studies involving 1,133 patients was sedation which occurred in approximately two-thirds of the patients. Although sedated, these patients could easily be aroused to an alert state.
Other less frequent adverse reactions occurring in 5-10% of the patients were:
Nausea Dizziness/Vertigo
Occurring in 1-5% of the patients:
Sweating Headache
Hypotension Nausea/Vomiting
Vomiting Hypoventilation
Miosis
The following adverse reactions were reported to have occurred in less than 1% of the patients:
CNS Effect:
Cardiovascular:
Gastrointestinal:
Respiratory:
Dermatological:
Ophthalmological:
Miscellaneous:
Other effects observed infrequently include malaise, hallucinations, depersonalization, coma, dyspepsia, flatulence, apnea, rash, amblyopia, tremor, and pallor.
The following reactions have been reported to occur rarely: loss of appetite, dysphoria/agitation, diarrhea, urticaria, and convulsions/lack of muscle coordination.
Allergic Reactions:
In the United Kingdom, buprenorphine hydrochloride was made available under monitored release regulation during the first year of sale, and yielded data from 1,736 physicians on 9,123 patients (17,120 administrations). Data on 240 children under the age of 18 years were included in this monitored release program. No important new adverse effects attributable to buprenorphine hydrochloride were observed.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
Review
Professional
Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
Tips
Interactions
Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).