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Buprenorphine
Overview
What is Buprenorphine?
Buprenorphine Sublingual Tablets are uncoated oval orange tablets, imprinted with a logo on one side and a numeric imprint on the other side. The tablets contain buprenorphine HCl and are available in two dosage strengths, 2 mg buprenorphine and 8 mg buprenorphine (as free base). Each tablet also contains citric acid anhydrous, crospovidone, FD&C yellow #6 HT aluminum lake, lactose monohydrate, magnesium stearate, mannitol, pregelatinized starch (maize), povidone, sodium citrate dihydrate.
Chemically, buprenorphine HCl, USP is (2S)-2-[17-Cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol hydrochloride. It has the following chemical structure:
Buprenorphine HCl, USP has the molecular formula C
H
NO•HCl and the molecular weight is 504.10. It is a white or off-white crystalline powder, sparingly soluble in water, freely soluble in methanol, soluble in alcohol and practically insoluble in cyclohexane.
What does Buprenorphine look like?
What are the available doses of Buprenorphine?
Sublingual tablet: buprenorphine 2 mg and buprenorphine 8 mg. ()
What should I talk to my health care provider before I take Buprenorphine?
How should I use Buprenorphine?
Buprenorphine Sublingual Tablets are indicated for the treatment of opioid dependence and is preferred for induction. Buprenorphine Sublingual Tablets should be used as part of a complete treatment plan to include counseling and psychosocial support.
Under the Drug Addiction Treatment Act (DATA) codified at 21 U.S.C. 823(g), prescription use of this product in the treatment of opioid dependence is limited to healthcare providers who meet certain qualifying requirements, and who have notified the Secretary of Health and Human Services (HHS) of their intent to prescribe this product for the treatment of opioid dependence and have been assigned a unique identification number that must be included on every prescription.
What interacts with Buprenorphine?
Sorry No Records found
What are the warnings of Buprenorphine?
Sorry No Records found
What are the precautions of Buprenorphine?
Sorry No Records found
What are the side effects of Buprenorphine?
Sorry No records found
What should I look out for while using Buprenorphine?
Buprenorphine Sublingual Tablets are contraindicated in patients with a history of hypersensitivity to buprenorphine, as serious adverse reactions, including anaphylactic shock, have been reported
What might happen if I take too much Buprenorphine?
Clinical Presentation
The manifestations of acute overdose include pinpoint pupils, sedation, hypotension, respiratory depression, and death.
Treatment of Overdose
In the event of overdose, the respiratory and cardiac status of the patient should be monitored carefully. When respiratory or cardiac functions are depressed, primary attention should be given to the re-establishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Oxygen, IV fluids, vasopressors, and other supportive measures should be employed as indicated.
In the case of overdose, the primary management should be the re-establishment of adequate ventilation with mechanical assistance of respiration, if required. Naloxone may be of value for the management of buprenorphine overdose. Higher than normal doses and repeated administration may be necessary. The long duration of action of buprenorphine should be taken into consideration when determining the length of treatment and medical surveillance needed to reverse the effects of an overdose. Insufficient duration of monitoring may put patients at risk.
How should I store and handle Buprenorphine?
Store at 20º to 25ºC (68º to 77ºF); excursions permitted to 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].Buprenorphine Sublingual Tablets are available as follows:2 mg – Oval, orange tablets debossed with on one side and 156 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3156-03).8 mg – Oval, orange tablets debossed with on one side and 153 on the other side. Tablets are supplied in bottles of 30 (NDC 0228-3153-03).Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in USP.CAUTION: DEA Order Form Required.Advise patients to store buprenorphine-containing medications safely and out of sight and reach of children[see Patient Counseling Information ()].
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Buprenorphine Sublingual Tablets contain buprenorphine, a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor.
Non-Clinical Toxicology
Buprenorphine Sublingual Tablets are contraindicated in patients with a history of hypersensitivity to buprenorphine, as serious adverse reactions, including anaphylactic shock, have been reportedAminoglutethimide:
Amphotericin B injection and potassium-depleting agents:
Anticholinesterases:
Anticoagulants, Oral:
Antidiabetics:
Antitubercular Drugs:
Cholestyramine:
Cyclosporine:
Dexamethasone Suppression Test (DST):
Digitalis Glycosides:
Ephedrine:
Estrogens, including Oral Contraceptives:
Hepatic Enzyme Inducers, Inhibitors and Substrates:
Ketoconazole:
Nonsteroidal Anti-Inflammatory Agents (NSAIDS):
Phenytoin:
Skin Tests:
Thalidomide:
Buprenorphine is a Schedule III controlled substance that can be abused in a manner similar to other opioids, legal or illicit. Prescribe and dispense buprenorphine with appropriate precautions to minimize risk of misuse, abuse, or diversion, and ensure appropriate protection from theft, including in the home. Clinical monitoring appropriate to the patient’s level of stability is essential. Multiple refills should not be prescribed early in treatment or without appropriate patient follow-up visits
The following serious adverse reactions are described elsewhere in the labeling:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
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