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Byetta

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Overview

What is Byetta?

BYETTA (exenatide) is a synthetic peptide that was originally identified in the lizard Exenatide differs in chemical structure and pharmacological action from insulin, sulfonylureas (including D-phenylalanine derivatives and meglitinides), biguanides, thiazolidinediones, alpha-glucosidase inhibitors, amylinomimetics and dipeptidyl peptidase-4 inhibitors.

Exenatide is a 39-amino acid peptide amide. Exenatide has the empirical formula CHNOS and molecular weight of 4186.6 Daltons. The amino acid sequence for exenatide is shown below.

H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH

BYETTA is supplied for SC injection as a sterile, preserved isotonic solution in a glass cartridge that has been assembled in a pen-injector (pen). Each milliliter (mL) contains 250 micrograms (mcg) synthetic exenatide, 2.2 mg metacresol as an antimicrobial preservative, mannitol as a tonicity-adjusting agent, and glacial acetic acid and sodium acetate trihydrate in water for injection as a buffering solution at pH 4.5. Two prefilled pens are available to deliver unit doses of 5 mcg or 10 mcg. Each prefilled pen will deliver 60 doses to provide for 30 days of twice daily administration (BID).



What does Byetta look like?



What are the available doses of Byetta?

BYETTA is supplied as 250 mcg/mL exenatide in:

What should I talk to my health care provider before I take Byetta?

How should I use Byetta?

BYETTA (exenatide) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [see ].

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2.1

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2.1


What interacts with Byetta?

Sorry No Records found


What are the warnings of Byetta?

Sorry No Records found


What are the precautions of Byetta?

Sorry No Records found


What are the side effects of Byetta?

Sorry No records found


What should I look out for while using Byetta?

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4.1


What might happen if I take too much Byetta?

In a clinical study of BYETTA, three patients with type 2 diabetes each experienced a single overdose of 100 mcg SC (10 times the maximum recommended dose). Effects of the overdoses included severe nausea, severe vomiting, and rapidly declining blood glucose concentrations. One of the three patients experienced severe hypoglycemia requiring parenteral glucose administration. The three patients recovered without complication. In the event of overdose, appropriate supportive treatment should be initiated according to the patient's clinical signs and symptoms.


How should I store and handle Byetta?

Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Pioglitazone Tablets, USP are available containing pioglitazone hydrochloride, USP equivalent to 15 mg, 30 mg or 45 mg of pioglitazone base. The 15 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0048-93bottles of 30 tabletsNDC 0378-0048-77bottles of 90 tabletsNDC 0378-0048-05bottles of 500 tablets The 30 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0228-93bottles of 30 tabletsNDC 0378-0228-77bottles of 90 tabletsNDC 0378-0228-05bottles of 500 tabletsThe 45 mg tablets are white to off-white, round, unscored tablets debossed with over on one side of the tablet and blank on the other side. They are available as follows:NDC 0378-0318-93bottles of 30 tabletsNDC 0378-0318-77bottles of 90 tabletsNDC 0378-0318-05bottles of 500 tabletsStorage:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Incretins, such as glucagon-like peptide-1 (GLP-1), enhance glucose-dependent insulin secretion and exhibit other antihyperglycemic actions following their release into the circulation from the gut. BYETTA is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying.

The amino acid sequence of exenatide partially overlaps that of human GLP-1. Exenatide has been shown to bind and activate the human GLP-1 receptor . This leads to an increase in both glucose-dependent synthesis of insulin, and secretion of insulin from pancreatic beta cells, by mechanisms involving cyclic AMP and/or other intracellular signaling pathways.

BYETTA improves glycemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes through the actions described below.

Non-Clinical Toxicology
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4.1

Use of daunorubicin in a patient who has previously received doxorubicin increases the risk of cardiotoxicity. Daunorubicin hydrochloride should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or daunorubicin hydrochloride. Cyclophosphamide used concurrently with daunorubicin hydrochloride may also result in increased cardiotoxicity.

Dosage reduction of daunorubicin hydrochloride may be required when used concurrently with other myelosuppressive agents.

Hepatotoxic medications, such as high-dose methotrexate, may impair liver function and increase the risk of toxicity.

BYETTA pens must never be shared between patients, even if the needle is changed. Pen-sharing poses a risk for transmission of blood-borne pathogens.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).