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Carbidopa, levodopa and entacapone

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Overview

What is Carbidopa, levodopa and entacapone?

Carbidopa, levodopa and entacapone tablets are combination of carbidopa, levodopa, and entacapone for the treatment of Parkinson’s disease.

Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (-)-L-(α-hydrazino-(α-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is CHNO•HO, and its structural formula is:

Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (-)-L-α-amino-β-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is CHNO, and its structural formula is:

Entacapone, a COMT inhibitor, is a nitro‑catechol‑structured compound with a molecular weight of 305.3. The chemical name of entacapone is (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Its empirical formula is CHNO and its structural formula is:

Carbidopa, levodopa and entacapone is supplied as tablets in 6 strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg, containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone; carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg, containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone; carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg, containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone; carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg, containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone; carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg, containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone; carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg, containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The inactive ingredients of the carbidopa, levodopa and entacapone tablets are corn starch, croscarmellose sodium, glycerol 85%, hypromellose, magnesium stearate, mannitol, polysorbate 80, povidone, sucrose, red iron oxide, and titanium dioxide. Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg, 25 mg/100 mg/200 mg and 37.5 mg/150 mg/200 mg also contain yellow iron oxide.



What does Carbidopa, levodopa and entacapone look like?



What are the available doses of Carbidopa, levodopa and entacapone?

Each carbidopa, levodopa and entacapone tablet contains a 1:4 ratio of carbidopa to levodopa and 200 mg of entacapone (mg of carbidopa per mg of levodopa per mg of entacapone)

What should I talk to my health care provider before I take Carbidopa, levodopa and entacapone?

How should I use Carbidopa, levodopa and entacapone?

Carbidopa, levodopa and entacapone tablets, a combination drug consisting of levodopa, carbidopa (dopa decarboxylase inhibitor), and entacapone (catechol-O-methyltransferase-COMT inhibitor) is indicated for the treatment of Parkinson’s disease.

Carbidopa, levodopa and entacapone tabletscan be used:

Carbidopa, levodopa and entacapone tablets should be used as a substitute for patients already stabilized on equivalent doses of carbidopa/levodopa and entacapone. However, some patients who have been stabilized on a given dose of carbidopa/levodopa may be treated with carbidopa, levodopa and entacapone tablets if a decision has been made to add entacapone (see below). Therapy should be individualized and adjusted according to the desired therapeutic response.


What interacts with Carbidopa, levodopa and entacapone?

Sorry No Records found


What are the warnings of Carbidopa, levodopa and entacapone?

Sorry No Records found


What are the precautions of Carbidopa, levodopa and entacapone?

Sorry No Records found


What are the side effects of Carbidopa, levodopa and entacapone?

Sorry No records found


What should I look out for while using Carbidopa, levodopa and entacapone?

Carbidopa, levodopa and entacapone tablets are contraindicated in patients:


What might happen if I take too much Carbidopa, levodopa and entacapone?


How should I store and handle Carbidopa, levodopa and entacapone?

Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Keep tightly closed (protect from moisture). Protect from light.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone tablets 12.5 mg/50 mg/200 mg film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone. The round, biconvex-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 50” on one side.HDPE bottle of 100 tablets ……………………………… NDC 47335-001-88Carbidopa, levodopa and entacapone tablets 18.75 mg/75 mg/200 mg film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 75” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-002-88Carbidopa, levodopa and entacapone tablets 25 mg/100 mg/200 mg film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 100” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-003-88Carbidopa, levodopa and entacapone tablets 31.25 mg/125 mg/200 mg film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone. The oval-shaped tablets are light brownish red, unscored and embossed with code “T1 125” on one side.HDPE bottle of 100 tablets……………………………… NDC 47335-004-88Carbidopa, levodopa and entacapone tablets 37.5 mg/150 mg/200 mg film-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “T1 150” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-005-88Carbidopa, levodopa and entacapone tablets 50 mg/200 mg/200 mg film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “T1 200” on one side. HDPE bottle of 100 tablets……………………………… NDC 47335-006-88Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). [See USP Controlled Room Temperature.]Dispense in tight container (USP).


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Current evidence indicates that symptoms of Parkinson’s disease are related to depletion of dopamine in the corpus striatum. Administration of dopamine is ineffective in the treatment of Parkinson’s disease because it does not cross the blood‑brain barrier. However, levodopa the metabolic precursor of dopamine, does cross the blood‑brain barrier, and is presumably converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa relieves the symptoms of Parkinson’s disease.

 

Carbidopa

When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. Carbidopa inhibits the decarboxylation of peripheral levodopa, making more levodopa available for delivery to the brain.

 

Entacapone

Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).

COMT catalyzes the transfer of the methyl group of S‑adenosyl‑L‑methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include DOPA, catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When decarboxylation of levodopa is prevented by carbidopa, COMT becomes the major metabolizing enzyme for levodopa, catalyzing its metabolism to 3‑methoxy‑4‑hydroxy‑L‑phenylalanine (3‑OMD).

Non-Clinical Toxicology
Carbidopa, levodopa and entacapone tablets are contraindicated in patients:

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, quinolones and beta-adrenergic blocking agents. When such drugs are administered to a patient receiving glipizide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for loss of control. binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of glipizide with these drugs.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving glipizide, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for hypoglycemia.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received glipizide alone and following treatment with 100 mg of fluconazole as a single daily oral dose for 7 days. The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).

In studies assessing the effect of colesevelam on the pharmacokinetics of glipizide ER in healthy volunteers, reductions in glipizide AUC and C of 12% and 13%, respectively were observed when colesevelam was coadministered with glipizide ER. When glipizide ER was administered 4 hours prior to colesevelam, there was no significant change in glipizide AUC or C , -4% and 0%, respectively. Therefore, glipizide tablets should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide.

The following adverse reactions described in this section are related to at least one of the components of carbidopa, levodopa and entacapone tablets (i.e., levodopa, carbidopa, and/or entacapone) based upon the safety experience in clinical trials (especially pivotal trials) or in postmarketing reports.

The following adverse reactions are discussed in more detail in the Warnings and Precautions sections of labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).