Carbidopa, Levodopa, and Entacapone

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Overview

What is Carbidopa, Levodopa, and Entacapone?

Carbidopa, levodopa and entacapone tablets are a combination of carbidopa, levodopa, and entacapone for the treatment of Parkinson's disease.

Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (-)-L-(α-hydrazino-(α-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is CHNO•HO, and its structural formula is:

Tablet content is expressed in terms of anhydrous carbidopa, which has a molecular weight of 226.3.

Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (-)-L-α-amino-β-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is CHNO, and its structural formula is:

Entacapone, a COMT inhibitor, is a nitro-catechol-structured compound with a molecular weight of 305.3. The chemical name of entacapone is (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Its empirical formula is CHNO and its structural formula is:

Carbidopa, Levodopa and Entacapone Tablets are supplied as tablets in 6 strengths:

Carbidopa, Levodopa and Entacapone Tablets: 12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone

Carbidopa, Levodopa and Entacapone Tablets: 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone

Carbidopa, Levodopa and Entacapone Tablets: 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone

Carbidopa, Levodopa and Entacapone Tablets: 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone

Carbidopa, Levodopa and Entacapone Tablets: 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone

Carbidopa, Levodopa and Entacapone Tablets: 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone

Inactive Ingredients:

What does Carbidopa, Levodopa, and Entacapone look like?

What are the available doses of Carbidopa, Levodopa, and Entacapone?

Each carbidopa, levodopa and entacapone tablet contains a 1:4 ratio of carbidopa to levodopa and 200 mg of entacapone (mg of carbidopa per mg of levodopa per mg of entacapone)

What should I talk to my health care provider before I take Carbidopa, Levodopa, and Entacapone?

How should I use Carbidopa, Levodopa, and Entacapone?

Carbidopa, levodopa and entacapone tablets, a combination drug consisting of levodopa, carbidopa (dopa decarboxylase inhibitor), and entacapone (catechol-O-methyltransferase-COMT inhibitor) is indicated for the treatment of Parkinson's disease.

Carbidopa, levodopa and entacapone tablets can be used:

Carbidopa, levodopa and entacapone tablets should be used as a substitute for patients already stabilized on equivalent doses of carbidopa/levodopa and entacapone. However, some patients who have been stabilized on a given dose of carbidopa/levodopa may be treated with carbidopa, levodopa and entacapone tablets if a decision has been made to add entacapone (see below). Therapy should be individualized and adjusted according to the desired therapeutic response.

What interacts with Carbidopa, Levodopa, and Entacapone?

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What are the warnings of Carbidopa, Levodopa, and Entacapone?

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What are the precautions of Carbidopa, Levodopa, and Entacapone?

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What are the side effects of Carbidopa, Levodopa, and Entacapone?

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What should I look out for while using Carbidopa, Levodopa, and Entacapone?

Carbidopa, levodopa and entacapone tablets are contraindicated in patients:

What might happen if I take too much Carbidopa, Levodopa, and Entacapone?

How should I store and handle Carbidopa, Levodopa, and Entacapone?

Store at 20° to 25˚C (68° to 77˚F). Excursions permitted to 15˚ to 30˚C (59˚ to 86˚F). [See USP Controlled Room Temperature.] Protect from freezing. Avoid excessive heat. The vial stopper is not made with natural rubber latex.Store at 20° to 25˚C (68° to 77˚F). Excursions permitted to 15˚ to 30˚C (59˚ to 86˚F). [See USP Controlled Room Temperature.] Protect from freezing. Avoid excessive heat. The vial stopper is not made with natural rubber latex.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.Carbidopa, levodopa and entacapone tablets are supplied as film-coated tablets for oral administration in the following six strengths:Carbidopa, levodopa and entacapone film-coated tablets containing 12.5 mg of carbidopa, 50 mg of levodopa, and 200 mg of entacapone.The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 50” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 18.75 mg of carbidopa, 75 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 75” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 25 mg of carbidopa, 100 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 100” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 31.25 mg of carbidopa, 125 mg of levodopa, and 200 mg of entacapone.The oval-shaped tablets are light brownish red, unscored and embossed with code “LCE 125” on one side.Carbidopa, levodopa and entacaponefilm-coated tablets containing 37.5 mg of carbidopa, 150 mg of levodopa, and 200 mg of entacapone.The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed “LCE 150” on one side.Carbidopa, levodopa and entacapone film-coated tablets containing 50 mg of carbidopa, 200 mg of levodopa, and 200 mg of entacapone.The oval shaped tablets are dark brownish red, unscored, and embossed “LCE 200” on one side.

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology

Carbidopa, levodopa and entacapone tablets are contraindicated in patients:

Bile acid sequestering agents such as cholestyramine and colestipol may interfere with the action of ursodiol by reducing its absorption. Aluminum-based antacids have been shown to adsorb bile acids and may be expected to interfere with ursodiol in the same manner as the bile acid sequestering agents. Estrogens, oral contraceptives, and clofibrate (and perhaps other lipid-lowering drugs) increase hepatic cholesterol secretion, and encourage cholesterol gallstone formation and hence may counteract the effectiveness of ursodiol.

The following adverse reactions described in this section are related to at least one of the components of carbidopa, levodopa and entacapone tablets (i.e., levodopa, carbidopa, and/or entacapone) based upon the safety experience in clinical trials (especially pivotal trials) or in postmarketing reports.

The following adverse reactions are discussed in more detail in the Warnings and Precautions sections of labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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