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Cefazolin

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Overview

What is Cefazolin?

CEFAZOLIN FOR INJECTION is a semi-synthetic cephalosporin for parenteral administration. It is the sodium salt of 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-methyl}-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid.

Structural Formula:

CEFAZOLIN FOR INJECTION is a sterile white to cream powder supplied in vials. Each vial contains, cefazolin sodium equivalent to 500 mg or 1 gram of cefazolin.

The sodium content is approximately 24 mg (1 mEq)/500 mg of cefazolin sodium or approximately 48 mg (2.1 mEq)/1 gram of cefazolin sodium.

The color of CEFAZOLIN FOR INJECTION solutions may range from pale yellow to yellow without a change in potency.

CEFAZOLIN FOR INJECTION is to be administered by intramuscular or intravenous routes.



What does Cefazolin look like?



What are the available doses of Cefazolin?

Sorry No records found.

What should I talk to my health care provider before I take Cefazolin?

Sorry No records found

How should I use Cefazolin?

CEFAZOLIN FOR INJECTION is indicated in the treatment of the following infections due to susceptible organisms:

Perioperative Prophylactic Use:

It is important that (1) the preoperative dose be given just (½ to 1 hour) prior to the start of surgery so that adequate antibiotic levels are present in the serum and tissues at the time of initial surgical incision; and (2) CEFAZOLIN FOR INJECTION be administered, if necessary, at appropriate intervals during surgery to provide sufficient levels of the antibiotic at the anticipated moments of greatest exposure to infective organisms.

In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of CEFAZOLIN FOR INJECTION may be continued for 3 to 5 days following the completion of surgery.


What interacts with Cefazolin?

CEFAZOLIN FOR INJECTION IS CONTRAINDICATED IN PATIENTS WITH KNOWN ALLERGY TO THE CEPHALOSPORIN GROUP OF ANTIBIOTICS.



What are the warnings of Cefazolin?

Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute.

BEFORE THERAPY WITH CEFAZOLIN FOR INJECTION IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFAZOLIN, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. IF THIS PRODUCT IS GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. IF AN ALLERGIC REACTION TO CEFAZOLIN FOR INJECTION OCCURS, DISCONTINUE TREATMENT WITH THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, IV FLUIDS, IV ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED.

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of , and surgical evaluation should be instituted as clinically indicated.


What are the precautions of Cefazolin?

General:

When CEFAZOLIN FOR INJECTION is administered to patients with low urinary output because of impaired renal function, lower daily dosage is required (see ).

As with other beta-lactam antibiotics, seizures may occur if inappropriately high doses are administered to patients with impaired renal function (see ).

CEFAZOLIN FOR INJECTION, as with all cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.

Prescribing CEFAZOLIN FOR INJECTION in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Drug Interactions:

Drug/Laboratory Test Interactions:

Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery.

Information for Patients:

Patients should be counseled that antibacterial drugs including CEFAZOLIN FOR INJECTION, should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When CEFAZOLIN FOR INJECTION is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may: (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by CEFAZOLIN FOR INJECTION or other antibacterial drugs in the future.

Carcinogenesis/Mutagenesis:

Pregnancy:

Teratogenic Effects:

Labor and Delivery:

Nursing Mothers:

Pediatric Use:

Geriatric Use:

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see and ).


What are the side effects of Cefazolin?

The following reactions have been reported:

Gastrointestinal:

Allergic:

Hematologic:

Hepatic:

Renal:

Local Reactions:

Other Reactions:

Cephalosporin-class Adverse Reactions:

Adverse Reactions: Allergic reactions, urticaria, serum sickness-like reaction, erythema multiforme, toxic epidermal necrolysis, colitis, renal dysfunction, toxic nephropathy, abdominal pain, reversible hyperactivity, hypertonia, hepatic dysfunction including cholestasis, aplastic anemia, haemolytic anemia, hemorrhage, and superinfection.

Altered Laboratory Tests: Prolonged prothrombin time, positive direct Coombs' test, false-positive test for urinary glucose, elevated bilirubin, elevated LDH, increased creatinine, pancytopenia, and agranulocytosis.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see ). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.


What should I look out for while using Cefazolin?

CEFAZOLIN FOR INJECTION IS CONTRAINDICATED IN PATIENTS WITH KNOWN ALLERGY TO THE CEPHALOSPORIN GROUP OF ANTIBIOTICS.

BEFORE THERAPY WITH CEFAZOLIN FOR INJECTION IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFAZOLIN, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. IF THIS PRODUCT IS GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. IF AN ALLERGIC REACTION TO CEFAZOLIN FOR INJECTION OCCURS, DISCONTINUE TREATMENT WITH THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, IV FLUIDS, IV ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED.

Clostridium difficile

C. difficile

C. difficile

C. difficile

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of , and surgical evaluation should be instituted as clinically indicated.


What might happen if I take too much Cefazolin?

Sorry No Records found


How should I store and handle Cefazolin?

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).CEFAZOLIN FOR INJECTIONEach vial contains cefazolin sodium equivalent to 500 mg of cefazolin.NDC 52946-110-25 (package of 25 vials)Each vial contains cefazolin sodium equivalent to 1 gram of cefazolin.NDC 52946-111-25 (package of 25 vials)CEFAZOLIN FOR INJECTION is also available as follows:Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin.NDC 52946-112-10 (package of 10 pharmacy bulk packages)As with other cephalosporins, CEFAZOLIN FOR INJECTION tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.Before reconstitution protect from light and store at Controlled Room Temperature 20° to 25°C (68° to 77°F).


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

In vitro

in vitro

Non-Clinical Toxicology
CEFAZOLIN FOR INJECTION IS CONTRAINDICATED IN PATIENTS WITH KNOWN ALLERGY TO THE CEPHALOSPORIN GROUP OF ANTIBIOTICS.

BEFORE THERAPY WITH CEFAZOLIN FOR INJECTION IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFAZOLIN, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. IF THIS PRODUCT IS GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. IF AN ALLERGIC REACTION TO CEFAZOLIN FOR INJECTION OCCURS, DISCONTINUE TREATMENT WITH THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, IV FLUIDS, IV ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED.

Clostridium difficile

C. difficile

C. difficile

C. difficile

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of , and surgical evaluation should be instituted as clinically indicated.

Drug Interactions:

General:

When CEFAZOLIN FOR INJECTION is administered to patients with low urinary output because of impaired renal function, lower daily dosage is required (see ).

As with other beta-lactam antibiotics, seizures may occur if inappropriately high doses are administered to patients with impaired renal function (see ).

CEFAZOLIN FOR INJECTION, as with all cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.

Prescribing CEFAZOLIN FOR INJECTION in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

The following reactions have been reported:

Gastrointestinal:

Allergic:

Hematologic:

Hepatic:

Renal:

Local Reactions:

Other Reactions:

Cephalosporin-class Adverse Reactions:

Adverse Reactions: Allergic reactions, urticaria, serum sickness-like reaction, erythema multiforme, toxic epidermal necrolysis, colitis, renal dysfunction, toxic nephropathy, abdominal pain, reversible hyperactivity, hypertonia, hepatic dysfunction including cholestasis, aplastic anemia, haemolytic anemia, hemorrhage, and superinfection.

Altered Laboratory Tests: Prolonged prothrombin time, positive direct Coombs' test, false-positive test for urinary glucose, elevated bilirubin, elevated LDH, increased creatinine, pancytopenia, and agranulocytosis.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see ). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

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Tips

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Interactions

Interactions

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