Clindamycin Phosphate and Tretinoin

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Overview

What is Clindamycin Phosphate and Tretinoin?

Clindamycin phosphate and tretinoin gel 1.2% / 0.025%, is an antibiotic and retinoid combination gel product with two active ingredients. Clindamycin phosphate, USP is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

The chemical name for clindamycin phosphate, USP is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl--4- propyl-L-2-pyrrolidinecarboxamido)-1-thio-L--α-D--octopyranoside 2-(dihydrogen phosphate). The structural formula for clindamycin phosphate, USP is represented below:

Clindamycin phosphate, USP:

Molecular Formula: CHClNOPS Molecular Weight: 504.97

The chemical name for tretinoin, USP is 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8- nonatetraenoic acid (all- form). The structural formula for tretinoin, USP is represented below:

Tretinoin, USP:

Molecular Formula: CHO Molecular Weight: 300.44

Clindamycin phosphate and tretinoin gel 1.2% / 0.025% contains the following inactive ingredients: anhydrous citric acid, butylated hydroxytoluene, edetate disodium, hydroxyethyl cellulose, glycerin, methylparaben, polysorbate 80, propylparaben, purified water, tromethamine and xanthan gum.

What does Clindamycin Phosphate and Tretinoin look like?

What are the available doses of Clindamycin Phosphate and Tretinoin?

Topical gel: Clindamycin phosphate, USP 1.2% and tretinoin, USP 0.025% gel in 30 and 60 gram tubes. ()

What should I talk to my health care provider before I take Clindamycin Phosphate and Tretinoin?

How should I use Clindamycin Phosphate and Tretinoin?

Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is indicated for the topical treatment of acne vulgaris in patients 12 years or older.

At bedtime, squeeze a pea-sized amount of medication onto one fingertip, dot onto the chin, cheeks, nose, and forehead, then gently rub over the entire face. Clindamycin phosphate and tretinoin gel should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes.

Clindamycin phosphate and tretinoin gel is not for oral, ophthalmic, or intravaginal use.

What interacts with Clindamycin Phosphate and Tretinoin?

Sorry No Records found

What are the warnings of Clindamycin Phosphate and Tretinoin?

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What are the precautions of Clindamycin Phosphate and Tretinoin?

Sorry No Records found

What are the side effects of Clindamycin Phosphate and Tretinoin?

Sorry No records found

What should I look out for while using Clindamycin Phosphate and Tretinoin?

Clindamycin phosphate and tretinoin gel is contraindicated in patients with regional enteritis, ulcerative colitis, or history of antibiotic-associated colitis.

What might happen if I take too much Clindamycin Phosphate and Tretinoin?

Sorry No Records found

How should I store and handle Clindamycin Phosphate and Tretinoin?

Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.Clindamycin phosphate and tretinoin gel 1.2% / 0.025% is supplied as follows:30 gram tube NDC 0472-1790-3060 gram tube NDC 0472-1790-60Storage and HandlingStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from light. Protect from freezing. Keep away from heat.Keep tube tightly closed.Keep out of the reach of children.

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Clinical Information

Chemical Structure

No Image found

Clinical Pharmacology

Clindamycin

[see ].

Tretinoin

Although the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.

Non-Clinical Toxicology

Clindamycin phosphate and tretinoin gel is contraindicated in patients with regional enteritis, ulcerative colitis, or history of antibiotic-associated colitis.

Systemic absorption of clindamycin has been demonstrated following topical use of this product. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical clindamycin. When significant diarrhea occurs, clindamycin phosphate and tretinoin gel should be discontinued.

Severe colitis has occurred following oral or parenteral administration of clindamycin with an onset of up to several weeks following cessation of therapy. Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen severe colitis. Severe colitis may result in death.

Studies indicate a toxin(s) produced by clostridia is one primary cause of antibiotic-associated colitis. The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus. Stool cultures for and stool assay for toxin may be helpful diagnostically.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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