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Clonidine hydrochloride extended-release
Overview
What is Clonidine hydrochloride extended-release?
Clonidine hydrochloride extended-release tablets are a centrally acting alpha-adrenergic agonist available as a 0.1 mg extended-release tablet for oral administration. Each 0.1 mg tablet is equivalent to 0.087 mg of the free base.
The inactive ingredients are sodium lauryl sulfate, lactose monohydrate, hypromellose type 2208, partially pregelatinized starch, colloidal silicon dioxide, and magnesium stearate. The formulation is designed to delay the absorption of active drug in order to decrease peak to trough plasma concentration differences. Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical name is 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride. The following is the structural formula:
CHClN•HCl Mol. Wt. 266.56
Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol.
What does Clonidine hydrochloride extended-release look like?
What are the available doses of Clonidine hydrochloride extended-release?
Extended-release tablets: 0.1 mg, not scored. ()
What should I talk to my health care provider before I take Clonidine hydrochloride extended-release?
How should I use Clonidine hydrochloride extended-release?
Clonidine hydrochloride extended-release tablets are indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications .
Clonidine hydrochloride extended-release tablets are to be taken orally with or without food.
Due to the lack of controlled clinical trial data and differing pharmacokinetic profiles, substitution of clonidine hydrochloride extended-release tablets for other clonidine products on a mg-per-mg basis is not recommended
What interacts with Clonidine hydrochloride extended-release?
Sorry No Records found
What are the warnings of Clonidine hydrochloride extended-release?
Sorry No Records found
What are the precautions of Clonidine hydrochloride extended-release?
Sorry No Records found
What are the side effects of Clonidine hydrochloride extended-release?
Sorry No records found
What should I look out for while using Clonidine hydrochloride extended-release?
Clonidine hydrochloride extended-release tablets are contraindicated in patients with a history of a hypersensitivity reaction to clonidine. Reactions have included generalized rash, urticaria, and angioedema .
What might happen if I take too much Clonidine hydrochloride extended-release?
Symptoms
Clonidine overdose:
Treatment
Consult with a Certified Poison Control Center (1-800-222-1222) for up-to-date guidance and advice.
How should I store and handle Clonidine hydrochloride extended-release?
Keep testosterone topical solution out of reach of children.Store upright at 25°C (77°F). Excursions are permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature. Used testosterone topical solution bottles and applicators should be discarded in household trash in a manner that prevents accidental exposure of children or pets. Keep testosterone topical solution out of reach of children.Store upright at 25°C (77°F). Excursions are permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature. Used testosterone topical solution bottles and applicators should be discarded in household trash in a manner that prevents accidental exposure of children or pets. Keep testosterone topical solution out of reach of children.Store upright at 25°C (77°F). Excursions are permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature. Used testosterone topical solution bottles and applicators should be discarded in household trash in a manner that prevents accidental exposure of children or pets. Clonidine hydrochloride extended-release tablets are white, non-scored, standard convex with debossing ("651") on one side.NDC 66993-776-60 – 0.1 mg round tablets supplied in bottles containing 60 tablets.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight container.Clonidine hydrochloride extended-release tablets are white, non-scored, standard convex with debossing ("651") on one side.NDC 66993-776-60 – 0.1 mg round tablets supplied in bottles containing 60 tablets.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight container.Clonidine hydrochloride extended-release tablets are white, non-scored, standard convex with debossing ("651") on one side.NDC 66993-776-60 – 0.1 mg round tablets supplied in bottles containing 60 tablets.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight container.Clonidine hydrochloride extended-release tablets are white, non-scored, standard convex with debossing ("651") on one side.NDC 66993-776-60 – 0.1 mg round tablets supplied in bottles containing 60 tablets.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight container.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Clonidine stimulates alpha-adrenergic receptors in the brain. Clonidine is not a central nervous system stimulant. The mechanism of action of clonidine in ADHD is not known.
Non-Clinical Toxicology
Clonidine hydrochloride extended-release tablets are contraindicated in patients with a history of a hypersensitivity reaction to clonidine. Reactions have included generalized rash, urticaria, and angioedema .The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.
Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.
Treatment with clonidine hydrochloride extended-release tablets can cause dose-related decreases in blood pressure and heart rate . Measure heart rate and blood pressure prior to initiation of therapy, following dose increases, and periodically while on therapy. Titrate clonidine hydrochloride extended-release tablets slowly in patients with a history of hypotension, and those with underlying conditions that may be worsened by hypotension and bradycardia; e.g., heart block, bradycardia, cardiovascular disease, vascular disease, cerebrovascular disease, or chronic renal failure. In patients who have a history of syncope or may have a condition that predisposes them to syncope, such as hypotension, orthostatic hypotension, bradycardia, or dehydration, advise patients to avoid becoming dehydrated or overheated. Monitor blood pressure and heart rate, and adjust dosages accordingly in patients treated concomitantly with antihypertensives or other drugs that can reduce blood pressure or heart rate or increase the risk of syncope.
The following serious adverse reactions are described in greater detail elsewhere in labeling:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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