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COLLAGENASE SANTYL

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Overview

What is COLLAGENASE SANTYL?

Collagenase Santyl Ointment is a sterile enzymatic debriding ointment which contains 250 collagenase units per gram of white petrolatum USP. The enzyme collagenase is derived from the fermentation by . It possesses the unique ability to digest collagen in necrotic tissue.



What does COLLAGENASE SANTYL look like?



What are the available doses of COLLAGENASE SANTYL?

Sorry No records found.

What should I talk to my health care provider before I take COLLAGENASE SANTYL?

Sorry No records found

How should I use COLLAGENASE SANTYL?

Collagenase Santyl Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

Collagenase Santyl Ointment should be applied once daily (or more frequently if the dressing becomes soiled, as from incontinence). When clinically indicated, crosshatching thick eschar with a #10 blade allows Collagenase Santyl Ointment more surface contact with necrotic debris. It is also desirable to remove, with forceps and scissors, as much loosened detritus as can be done readily. Use Collagenase Santyl Ointment in the following manner:

1 - Prior to application the wound should be cleansed of debris and digested material by gently rubbing with a gauze pad saturated with normal saline solution, or with the desired cleansing agent compatible with Collagenase Santyl Ointment (See ), followed by a normal saline solution rinse.

2 - Whenever infection is present, it is desirable to use an appropriate topical antibiotic powder. The antibiotic should be applied to the wound prior to the application of Collagenase Santyl Ointment. Should the infection not respond, therapy with Collagenase Santyl Ointment should be discontinued until remission of the infection.

3 - Collagenase Santyl Ointment may be applied directly to the wound or to a sterile gauze pad which is then applied to the wound and properly secured.

4 - Use of Collagenase Santyl Ointment should be terminated when debridement of necrotic tissue is complete and granulation tissue is well established.


What interacts with COLLAGENASE SANTYL?

Sorry No Records found


What are the warnings of COLLAGENASE SANTYL?

Sorry No Records found


What are the precautions of COLLAGENASE SANTYL?

Sorry No Records found


What are the side effects of COLLAGENASE SANTYL?

Sorry No records found


What should I look out for while using COLLAGENASE SANTYL?

Collagenase Santyl Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.


What might happen if I take too much COLLAGENASE SANTYL?

No systemic or local reaction attributed to overdose has been observed in clinical investigations and clinical use. If deemed necessary the enzyme may be inactivated by washing the area with povidone iodine.


How should I store and handle COLLAGENASE SANTYL?

Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP.Do not store above 25°C (77°F). Sterility guaranteed until tube is opened.Collagenase Santyl Ointment is available in the following sizes:30 g tube NDC 50484-010-3090 g tube NDC 50484-010-90REFERENCES1 – Mandl, I., Adv Enzymol. 23:163, 1961.2 – Boxer, A.M., Gottesman, N., Bernstein, H., & Mandl, I., Geriatrics. 24:75, 1969.3 – Mazurek, I., Med. Welt. 22:150, 1971.4 – Zimmermann, WE., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 131, p. 185.5 – Vetra, H., & Whittaker, D., Geriatrics. 30:53, 1975.6 – Rao, D.B., Sane, P.G., & Georgiev, E.L., J. Am. Geriatrics Soc. 23:22, 1975.7 – Vrabec, R., Moserova, J., Konickova, Z., Behounkova, E., & Blaha, J., J. Hyg. Epidemiol. Microbiol. Immunol. 18:496, 1974.8 – Lippmann, H.I., Arch. Phys. Med. Rehabil. 54:588, 1973.9 – German, F. M., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 165.10 – Haimovici, H. & Strauch, B., in “Collagenase,” Mandl, I., ed., Gordon & Breach, Science Publishers, New York, 1971, p. 177.11 – Lee, L.K., & Ambrus, J.L., Geriatrics. 30:91, 1975.12 – Locke, R.K., & Heifitz, N.M., J. Am. Pod. Assoc. 65:242, 1975.13 – Varma, A.O., Bugatch, E., & German, F.M., Surg. Gynecol. Obstet. 136:281, 1973.14 – Barrett, D., Jr., & Klibanski, A., Am. J. Nurs. 73:849, 1973.15 – Bardfeld, L.A., J. Pod. Ed. 1:41, 1970.16 – Blum, G., Schweiz, Rundschau Med Praxis. 62:820, 1973. Abstr. in Dermatology Digest, Feb. 1974, p. 36.17 – Zaruba, F., Lettl, A., Brozkova, L., Skrdlantova, H., & Krs, V., J. Hyg. Epidemiol. Microbiol. Immunol. 18:499, 1974.18 – Altman, M.I., Goldstein, L., & Horwitz, S., J. Am. Pod. Assoc. 68:11, 1978.19 – Rehn, V.J., Med. Klin. 58:799, 1963.20 – Krauss, H., Koslowski, L., & Zimmermann, W. E., Langenbecks Arch. Klin. Chir. 303:23, 1963.21 – Gruenagel, H.H., Med. Klin. 58:442, 1963.Manufactured by: SMITH & NEPHEW, INCFort Worth, Texas 76109US Gov’t License #2004Marketed by: Smith & Nephew 1-800-441-8227Smith & Nephew, Inc., Fort Worth, Texas 76109© 2016 Smith & Nephew, Inc.SANTYL is a registered trademark of Smith & Nephew, Inc.140749-0316


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Since collagen accounts for 75% of the dry weight of skin tissue, the ability of collagenase to digest collagen in the physiological pH and temperature range makes it particularly effective in the removal of detritus.   Collagenase thus contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas. Collagen in healthy tissue or in newly formed granulation tissue is not attacked. There is no information available on collagenase absorption through skin or its concentration in body fluids associated with therapeutic and/or toxic effects, degree of binding to plasma proteins, degree of uptake by a particular organ or in the fetus, and passage across the blood brain barrier.

Non-Clinical Toxicology
Collagenase Santyl Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.

The optimal pH range of collagenase is 6 to 8. Higher or lower pH conditions will decrease the enzyme’s activity and appropriate precautions should be taken. The enzymatic activity is also adversely affected by certain detergents, and heavy metal ions such as mercury and silver which are used in some antiseptics. When it is suspected such materials have been used, the site should be carefully cleansed by repeated washings with normal saline before Collagenase Santyl Ointment is applied. Soaks containing metal ions or acidic solutions should be avoided because of the metal ion and low pH. Cleansing materials such as Dakin’s solution and normal saline are compatible with Collagenase Santyl Ointment.

Debilitated patients should be closely monitored for systemic bacterial infections because of the theoretical possibility that debriding enzymes may increase the risk of bacteremia.

A slight transient erythema has been noted occasionally in the surrounding tissue, particularly when Collagenase Santyl Ointment was not confined to the wound. Therefore, the ointment should be applied carefully within the area of the wound. Safety and effectiveness in pediatric patients have not been established.

No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. However, one case of systemic manifestations of hypersensitivity to collagenase in a patient treated for more than one year with a combination of collagenase and cortisone has been reported.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).