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COMBIGAN
Overview
What is COMBIGAN?
COMBIGAN
The structural formulae are:
Brimonidine tartrate:
5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24
Timolol maleate:
(-)-1-(-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy]-2-propanol maleate (1:1) (salt); MW= 432.50 as the maleate salt
In solution, (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330 mOsmol/kg and a pH during its shelf life of 6.5-7.3.
Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.
Each mL of contains the active ingredients brimonidine tartrate 0.2% and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%; sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and hydrochloric acid and/or sodium hydroxide to adjust pH.
What does COMBIGAN look like?
What are the available doses of COMBIGAN?
Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol. ()
What should I talk to my health care provider before I take COMBIGAN?
Not for use in children below the age of 2 years. Use with caution in children ≥ 2 years of age. ()
How should I use COMBIGAN?
COMBIGAN
COMBIGAN
The recommended dose is one drop of in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.
What interacts with COMBIGAN?
Sorry No Records found
What are the warnings of COMBIGAN?
Sorry No Records found
What are the precautions of COMBIGAN?
Sorry No Records found
What are the side effects of COMBIGAN?
Sorry No records found
What should I look out for while using COMBIGAN?
Bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease. (, , )
Sinus bradycardia, atrioventricular block, overt cardiac failure, cardiogenic shock. (, )
Neonates and infants (under the age of 2 years). ()
Hypersensitivity to any component of this product. ()
What might happen if I take too much COMBIGAN?
There have been reports of inadvertent overdosage with timolol ophthalmic solution resulting in systemic effects similar to those seen with systemic beta-adrenergic blocking agents such as dizziness, headache, shortness of breath, bradycardia, bronchospasm, and cardiac arrest. With the exception of hypotension, very limited information exists on accidental ingestion of brimonidine in adults. Symptoms of brimonidine overdose have been reported in neonates, infants, and children receiving brimonidine ophthalmic solutions as part of medical treatment of congenital glaucoma or by accidental oral ingestion . Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained.
How should I store and handle COMBIGAN?
Store at 25ºC (77ºF), excursions permitted to 15ºC to 30ºC (59ºF to 86ºF). Do not refrigerate.[See USP Controlled Room Temperature.]Store at 25ºC (77ºF), excursions permitted to 15ºC to 30ºC (59ºF to 86ºF). Do not refrigerate.[See USP Controlled Room Temperature.]COMBIGAN 5 mL in 10 mL bottle NDC 0023-9211-0510 mL in 10 mL bottle NDC 0023-9211-1015 mL in 15 mL bottle NDC 0023-9211-15 COMBIGAN 5 mL in 10 mL bottle NDC 0023-9211-0510 mL in 10 mL bottle NDC 0023-9211-1015 mL in 15 mL bottle NDC 0023-9211-15
