Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

COMBIGAN

×

Overview

What is COMBIGAN?

COMBIGAN

The structural formulae are:

Brimonidine tartrate:

5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24

Timolol maleate:

(-)-1-(-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy]-2-propanol maleate (1:1) (salt); MW= 432.50 as the maleate salt

In solution, (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330 mOsmol/kg and a pH during its shelf life of 6.5-7.3.

Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.

Each mL of contains the active ingredients brimonidine tartrate 0.2% and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%; sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and hydrochloric acid and/or sodium hydroxide to adjust pH.



What does COMBIGAN look like?



What are the available doses of COMBIGAN?

Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol. ()

What should I talk to my health care provider before I take COMBIGAN?

Not for use in children below the age of 2 years. Use with caution in children ≥ 2 years of age. ()

How should I use COMBIGAN?

COMBIGAN

COMBIGAN

The recommended dose is one drop of in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.


What interacts with COMBIGAN?

Sorry No Records found


What are the warnings of COMBIGAN?

Sorry No Records found


What are the precautions of COMBIGAN?

Sorry No Records found


What are the side effects of COMBIGAN?

Sorry No records found


What should I look out for while using COMBIGAN?

Bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease. (, , )

Sinus bradycardia, atrioventricular block, overt cardiac failure, cardiogenic shock. (, )

Neonates and infants (under the age of 2 years). ()

Hypersensitivity to any component of this product. ()


What might happen if I take too much COMBIGAN?

There have been reports of inadvertent overdosage with timolol ophthalmic solution resulting in systemic effects similar to those seen with systemic beta-adrenergic blocking agents such as dizziness, headache, shortness of breath, bradycardia, bronchospasm, and cardiac arrest. With the exception of hypotension, very limited information exists on accidental ingestion of brimonidine in adults. Symptoms of brimonidine overdose have been reported in neonates, infants, and children receiving brimonidine ophthalmic solutions as part of medical treatment of congenital glaucoma or by accidental oral ingestion . Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained.


How should I store and handle COMBIGAN?

Store at 25ºC (77ºF), excursions permitted to 15ºC to 30ºC (59ºF to 86ºF). Do not refrigerate.[See USP Controlled Room Temperature.]Store at 25ºC (77ºF), excursions permitted to 15ºC to 30ºC (59ºF to 86ºF). Do not refrigerate.[See USP Controlled Room Temperature.]COMBIGAN 5 mL in 10 mL bottle           NDC 0023-9211-0510 mL in 10 mL bottle         NDC 0023-9211-1015 mL in 15 mL bottle         NDC 0023-9211-15 COMBIGAN 5 mL in 10 mL bottle           NDC 0023-9211-0510 mL in 10 mL bottle         NDC 0023-9211-1015 mL in 15 mL bottle         NDC 0023-9211-15


×

Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

COMBIGAN

COMBIGAN

Fluorophotometric studies in animals and humans suggest that brimonidine tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.

Timolol maleate is a beta and beta adrenergic receptor inhibitor that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity.

Non-Clinical Toxicology
Bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease. (, , )

Sinus bradycardia, atrioventricular block, overt cardiac failure, cardiogenic shock. (, )

Neonates and infants (under the age of 2 years). ()

Hypersensitivity to any component of this product. ()

COMBIGAN

[see Contraindications ()]

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

Rate this treatment and share your opinion


Learn about User Reviews

Helpful tips to write a good review:

  1. Only share your first hand experience as a consumer or a care giver.
  2. Describe your experience in the Comments area including the benefits, side effects and how it has worked for you. Do not provide personal information like email addresses or telephone numbers.
  3. Fill in the optional information to help other users benefit from your review.

Reason for Taking This Treatment

(required)

Click the stars to rate this treatment

Effectiveness (required)

This medication has worked for me.




Ease of Use (required)

This medication has been easy for me to use.




Satisfaction (required)

Overall, I have been satisfied with my experience.




Write a brief description of your experience with this treatment:

2000 characters remaining

Optional Information

Help others benefit from your review by filling in the information below.
I am a:
Gender:
×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
×

Tips

Tips

×

Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).