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Creon

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Overview

What is Creon?

CREON is a pancreatic enzyme preparation consisting of pancrelipase, an extract derived from porcine pancreatic glands. Pancrelipase contains multiple enzyme classes, including porcine-derived lipases, proteases, and amylases.

Pancrelipase is a beige-white amorphous powder. It is miscible in water and practically insoluble or insoluble in alcohol and ether.

Each delayed-release capsule for oral administration contains enteric-coated spheres (0.71–1.60 mm in diameter).

The active ingredient evaluated in clinical trials is lipase. CREON is dosed by lipase units.

Other active ingredients include protease and amylase.

CREON contains the following inactive ingredients: cetyl alcohol, dimethicone, hypromellose phthalate, polyethylene glycol, and triethyl citrate.

3,000 USP units of lipase;

6,000 USP units of lipase;

12,000 USP units of lipase;

24,000 USP units of lipase;

36,000 USP units of lipase;



What does Creon look like?



What are the available doses of Creon?

The active ingredient in CREON evaluated in clinical trials is lipase. CREON is dosed by lipase units.

Other active ingredients include protease and amylase. Each CREON delayed-release capsule strength contains the specified amounts of lipase, protease, and amylase as follows:

What should I talk to my health care provider before I take Creon?

How should I use Creon?

CREON (pancrelipase) is indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

CREON is not interchangeable with other pancrelipase products.

CREON is orally administered. Therapy should be initiated at the lowest recommended dose and gradually increased. The dosage of CREON should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet as described in the Limitations on Dosing below .


What interacts with Creon?

Sorry No Records found


What are the warnings of Creon?

Sorry No Records found


What are the precautions of Creon?

Sorry No Records found


What are the side effects of Creon?

Sorry No records found


What should I look out for while using Creon?

None.


What might happen if I take too much Creon?

There have been no reports of overdose in clinical trials or postmarketing surveillance with this formulation of CREON. Chronic high doses of pancreatic enzyme products have been associated with fibrosing colonopathy and colonic strictures . High doses of pancreatic enzyme products have been associated with hyperuricosuria and hyperuricemia, and should be used with caution in patients with a history of hyperuricemia, gout, or renal impairment .


How should I store and handle Creon?

Store at 25º C (77º F); excursions permitted to 15 to 30º C (59 to 86º F) [see USP Controlled Room Temperature].Do not store unpouched. Insert immediately upon removal from the protective pouch.Store at 25º C (77º F); excursions permitted to 15 to 30º C (59 to 86º F) [see USP Controlled Room Temperature].Do not store unpouched. Insert immediately upon removal from the protective pouch.CREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREONCREON (pancrelipase) Delayed-Release Capsules3,000 USP units of lipase; 9,500 USP units of protease; 15,000 USP units of amylaseEach CREON capsule is available as a two piece hypromellose capsule with a white opaque cap with imprint “CREON 1203” and a white opaque body that contains tan colored, delayed-release pancrelipase supplied in bottles of:CREON (pancrelipase) Delayed-Release Capsules 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1206” and a blue opaque body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with a brown opaque cap with imprint “CREON 1212” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase Each CREON capsule is available as a two-piece gelatin capsule with orange opaque cap with imprint “CREON 1224” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of: CREON (pancrelipase) Delayed-Release Capsules36,000 USP units of lipase; 114,000 USP units of protease; 180,000 USP units of amylaseEach CREON capsule is available as a two-piece gelatin capsule with blue opaque cap with imprint “CREON 1236” and a colorless transparent body that contains tan-colored, delayed-release pancrelipase supplied in bottles of:Storage and Handling CREON must be stored at room temperature up to 25°C (77°F) and protected from moisture. Temperature excursions are permitted between 25°C to 40°C (77°F and 104°F) for up to 30 days. Product should be discarded if exposed to higher temperature and moisture conditions higher than 70%. between uses to . Bottles of CREON 3,000 USP units of lipase must be stored and dispensed in the original container.Do not crush CREON


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Clinical Information

Chemical Structure

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Clinical Pharmacology

The pancreatic enzymes in CREON catalyze the hydrolysis of fats to monoglyceride, glycerol and free fatty acids, proteins into peptides and amino acids, and starches into dextrins and short chain sugars such as maltose and maltriose in the duodenum and proximal small intestine, thereby acting like digestive enzymes physiologically secreted by the pancreas.

Non-Clinical Toxicology
None.

Fibrosing colonopathy has been reported following treatment with different pancreatic enzyme products. Fibrosing colonopathy is a rare, serious adverse reaction initially described in association with high-dose pancreatic enzyme use, usually over a prolonged period of time and most commonly reported in pediatric patients with cystic fibrosis. The underlying mechanism of fibrosing colonopathy remains unknown. Doses of pancreatic enzyme products exceeding 6,000 lipase units/kg of body weight per meal have been associated with colonic stricture in children less than 12 years of age. Patients with fibrosing colonopathy should be closely monitored because some patients may be at risk of progressing to stricture formation. It is uncertain whether regression of fibrosing colonopathy occurs. It is generally recommended, unless clinically indicated, that enzyme doses should be less than 2,500 lipase units/kg of body weight per meal (or less than 10,000 lipase units/kg of body weight per day) or less than 4,000 lipase units/g fat ingested per day

Doses greater than 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day) should be used with caution and only if they are documented to be effective by 3-day fecal fat measures that indicate a significantly improved coefficient of fat absorption. Patients receiving higher doses than 6,000 lipase units/kg of body weight per meal should be examined and the dosage either immediately decreased or titrated downward to a lower range.

The most serious adverse reactions reported with different pancreatic enzyme products of the same active ingredient (pancrelipase) that are described elsewhere in the label include fibrosing colonopathy, hyperuricemia and allergic reactions .

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).