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CUBICIN RF (daptomycin for injection) contains daptomycin, a cyclic lipopeptide antibacterial agent derived from the fermentation of . The chemical name is -decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl--3-methyl-L-glutamyl-3-anthraniloyl-L-alanine ε-lactone. The chemical structure is:

The empirical formula is CHNO; the molecular weight is 1620.67. CUBICIN RF is supplied in a single-dose vial as a sterile, preservative-free, pale yellow to light brown, lyophilized powder containing 500 mg of daptomycin for intravenous (IV) use following reconstitution Each vial also contains 713 mg sucrose and sodium hydroxide is used to adjust the pH. The pH of the solution upon reconstitution is 6.8. Freshly reconstituted solutions of CUBICIN RF range in color from pale yellow to light brown.

What does CUBICIN RF look like?

What are the available doses of CUBICIN RF?

For Injection: 500 mg lyophilized powder for reconstitution in a single-dose vial ()

What should I talk to my health care provider before I take CUBICIN RF?

How should I use CUBICIN RF?

CUBICIN RF is indicated for the treatment of adult and pediatric patients (1 to 17 years of age) with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive bacteria: (including methicillin-resistant isolates), subsp. and (vancomycin-susceptible isolates only).

Administer to intravenously in 0.9% sodium chloride, either by injection over a 2-minute period or by infusion over a 30-minute period. (, )

Recommended dosage regimen for adult patients (, , ):

What interacts with CUBICIN RF?

Sorry No Records found

What are the warnings of CUBICIN RF?

Sorry No Records found

What are the precautions of CUBICIN RF?

Sorry No Records found

What are the side effects of CUBICIN RF?

Sorry No records found

What should I look out for while using CUBICIN RF?

CUBICIN RF is contraindicated in patients with known hypersensitivity to daptomycin.

What might happen if I take too much CUBICIN RF?

In the event of overdosage, supportive care is advised with maintenance of glomerular filtration. Daptomycin is cleared slowly from the body by hemodialysis (approximately 15% of the administered dose is removed over 4 hours) and by peritoneal dialysis (approximately 11% of the administered dose is removed over 48 hours). The use of high-flux dialysis membranes during 4 hours of hemodialysis may increase the percentage of dose removed compared with that removed by low-flux membranes.

How should I store and handle CUBICIN RF?

Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.CUBICIN RF (daptomycin for injection) is supplied as a sterile pale yellow to light brown lyophilized powder in a single-dose 10 mL vial containing 500 mg of daptomycin: Package of 1 (NDC 67919-012-02).


Clinical Information

Chemical Structure

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Clinical Pharmacology

Daptomycin is an antibacterial drug

Non-Clinical Toxicology
CUBICIN RF is contraindicated in patients with known hypersensitivity to daptomycin.

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.

Antagonism has been demonstrated between clindamycin and erythromycin . Because of possible clinical significance, these two drugs should not be administered concurrently.

Anaphylaxis/hypersensitivity reactions have been reported with the use of antibacterial agents, including CUBICIN, and may be life-threatening. If an allergic reaction to CUBICIN RF occurs, discontinue the drug and institute appropriate therapy

The following adverse reactions are described, or described in greater detail, in other sections:



This information is obtained from the National Institute of Health's Standard Packaging Label drug database.

While we update our database periodically, we cannot guarantee it is always updated to the latest version.



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