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fluticasone propionate

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Overview

What is Cutivate?

CUTIVATE (fluticasone propionate) Lotion, 0.05% contains fluticasone propionate [S-Fluoromethyl 6α, 9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate], a synthetic fluorinated corticosteroid, for topical use. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents.

Chemically, fluticasone propionate is CHFOS. It has the following structural formula:

Fluticasone propionate has a molecular weight of 500.6. It is a white to off-white powder and is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.

Each gram of CUTIVATE® Lotion contains 0.5 mg fluticasone propionate in a white to off white lotion base of cetomacrogol 1000, cetostearyl alcohol, citric acid monohydrate, dimethicone 350, imidurea, isopropyl myristate, methylparaben, propylene glycol, propylparaben, purified water, and sodium citrate.



What does Cutivate look like?



What are the available doses of Cutivate?

Lotion, 0.05%. Each gram of CUTIVATE® Lotion contains 0.5 mg fluticasone propionate in a white to off-white lotion base. CUTIVATE Lotion is supplied in 120 mL bottles.

What should I talk to my health care provider before I take Cutivate?

How should I use Cutivate?

CUTIVATE Lotion is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of atopic dermatitis in patients 3 months of age and older. ()

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What interacts with Cutivate?

Sorry No Records found


What are the warnings of Cutivate?

Sorry No Records found


What are the precautions of Cutivate?

Sorry No Records found


What are the side effects of Cutivate?

Sorry No records found


What should I look out for while using Cutivate?

None.


What might happen if I take too much Cutivate?

Sorry No Records found


How should I store and handle Cutivate?

Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]. Dispense in a tight, light-resistant container [see USP]. Protect from light and moisture.CUTIVATE (fluticasone propionate) Lotion, 0.05% is white to off-white in color, and supplied as follows:120 mL bottle NDC 10337-434-04CUTIVATE (fluticasone propionate) Lotion, 0.05% is white to off-white in color, and supplied as follows:120 mL bottle NDC 10337-434-04


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of CUTIVATE Lotion in atopic dermatitis is unknown.

Non-Clinical Toxicology
None.

Drug interactions:

Topical corticosteroids, including CUTIVATE Lotion, can produce reversible HPA axis suppression with the potential for glucocorticoid insufficiency. Risk factors that predispose to HPA axis suppression include the use of high-potency topical corticosteroids, large treatment surface areas, prolonged use, use under occlusion, concomitant use of more than one corticosteroid-containing product, altered skin barrier, and liver failure. Pediatric patients may be at greater risk of HPA axis suppression due to their higher skin surface area to body mass ratios [].

HPA axis suppression may occur during or after withdrawal of treatment. If HPA axis suppression is suspected, gradually withdraw the drug, reduce the frequency of application, or substitute a less potent topical corticosteroid. Evaluation of HPA axis suppression may be done by using the cosyntropin stimulation test.

The effects of CUTIVATE Lotion on HPA axis function in pediatric patients were investigated in two trials. Among a total of 89 evaluable subjects from the two trials who were treated with CUTIVATE Lotion twice daily for 3 to 4 weeks, a single subject with >90% body surface area treated showed laboratory evidence of transient suppression immediately post-treatment. The post cosyntropin stimulation test serum cortisol returned to a normal level (22.1µg/dL) within one week of the final treatment visit [].

Cushing’s syndrome, hyperglycemia, and unmasking of latent diabetes mellitus can also result from systemic absorption of topical corticosteroids.

Use of more than one corticosteroid-containing product at the same time may increase the total systemic absorption of topical corticosteroids.

The following adverse reactions are discussed in greater detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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