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Cyanokit

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Overview

What is Cyanokit?

Hydroxocobalamin, the active ingredient in Cyanokit, is cobinamide dihydroxide dihydrogen phosphate (ester), mono (inner salt), 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole. The drug substance is the hydroxylated active form of vitamin B and is a large molecule in which a trivalent cobalt ion is coordinated in four positions by a tetrapyrol (or corrin) ring. It is a hygroscopic, odorless, dark red, crystalline powder that is freely soluble in water and ethanol, and practically insoluble in acetone and diethyl ether. Hydroxocobalamin has a molecular weight of 1346.36 atomic mass units, an empirical formula of CHCoNOP and the following structural formula:

Cyanokit (hydroxocobalamin for injection) 5 g for intravenous infusion is a cyanide antidote package which contains one colorless 250 mL glass vial, containing 5 g dark red lyophilized hydroxocobalamin, pH adjusted with hydrochloric acid, one transfer spike, one intravenous administration set, one quick use reference guide and one package insert.

The 5 g vial of hydroxocobalamin for injection is to be reconstituted with 200 mL of 0.9% NaCl, to give a dark red injectable solution (25 mg/mL). If 0.9% NaCl is not readily available, 200 mL of either Lactated Ringers injection or 5% Dextrose injection (D5W) may be used as the diluent. Diluent is not included in the Cyanokit. The pH of the reconstituted product ranges from 3.5 to 6.0.



What does Cyanokit look like?



What are the available doses of Cyanokit?

Cyanokit (hydroxocobalamin for injection) 5 g for intravenous infusion consists of 1 vial, containing 5 g lyophilized hydroxocobalamin dark red crystalline powder for injection. () After reconstitution, the vial contains hydroxocobalamin for injection, 25 mg/mL. One 5 g vial is a complete starting dose. ()

What should I talk to my health care provider before I take Cyanokit?

How should I use Cyanokit?

Cyanokit is indicated for the treatment of known or suspected cyanide poisoning.

Comprehensive treatment of acute cyanide intoxication requires support of vital functions. Cyanokit should be administered in conjunction with appropriate airway, ventilatory and circulatory support.


What interacts with Cyanokit?

Sorry No Records found


What are the warnings of Cyanokit?

Sorry No Records found


What are the precautions of Cyanokit?

Sorry No Records found


What are the side effects of Cyanokit?

Sorry No records found


What should I look out for while using Cyanokit?

None


What might happen if I take too much Cyanokit?

No data are available about overdose with Cyanokit in adults. Should overdose occur, treatment should be directed to the management of symptoms. Hemodialysis may be effective in such a circumstance, but is only indicated in the event of significant hydroxocobalamin-related toxicity. Because of its deep red color, hydroxocobalamin may interfere with the performance of hemodialysis machines


How should I store and handle Cyanokit?

Unopened vials of XEOMIN can be stored at room temperature 20°C to 25°C (68°F to 77°F), in a refrigerator at 2°C to 8°C (36°F to 46°F), or a freezer at -20°C to -10°C (-4°F to 14°F). Do not use after the expiration date on the vial. Each Cyanokit carton (NDC 11704-370-01) consists of the following: Diluent is not included Each Cyanokit carton (NDC 11704-370-01) consists of the following: Diluent is not included