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CYPROHEPTADINE

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Overview

What is CYPROHEPTADINE?

Each 5 mL (one teaspoonful) contains: Cyproheptadine hydrochloride 2 mg. Alcohol 5%.

Inactive ingredients:

Cyproheptadine hydrochloride is an antihistaminic and antiserotonergic agent. Cyproheptadine hydrochloride is a white to slightly yellowish, crystalline solid, with a molecular weight of 350.88, which is slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol, soluble in chloroform and practically insoluble in ether. It is the sesquihydrate of 4-(5-Dibenzo [] cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride. The molecular formula of the anhydrous salt is CHN • HCl and the structural formula of the anhydrous salt is:



What does CYPROHEPTADINE look like?



What are the available doses of CYPROHEPTADINE?

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What should I talk to my health care provider before I take CYPROHEPTADINE?

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How should I use CYPROHEPTADINE?

Perennial and seasonal allergic rhinitis

Vasomotor rhinitis

Allergic conjunctivitis due to inhalant allergens and foods

Mild, uncomplicated allergic skin manifestations of urticaria and angioedema

Amelioration of allergic reactions to blood or plasma

Cold urticaria

Dermatographism

As therapy for anaphylactic reactions to epinephrine and other standard measures after the acute manifestations have been controlled.

DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.

Although intended primarily for administration to children, the oral solution is also used for administration to adults who cannot swallow tablets.


What interacts with CYPROHEPTADINE?

Sorry No Records found


What are the warnings of CYPROHEPTADINE?

Children

Overdosage of antihistamines, particularly in infants and children, may produce hallucinations, central nervous system depression, convulsions and death.

Antihistamines may diminish mental alertness; conversely, particularly in the young child, they may occasionally produce excitation.

CNS Depressants

Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.

Activities Requiring Mental Alertness

Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.

Antihistamines are more likely to cause dizziness, sedation and hypotension in elderly patients.


What are the precautions of CYPROHEPTADINE?

General

Cyproheptadine has an atropine-like action and, therefore, should be used with caution in patients with:

History of bronchial asthma

Increased intraocular pressure

Hyperthyroidism

Cardiovascular disease

Hypertension

Information for Patients

Antihistamines may diminish mental alertness; conversely, particularly in the young child, they may occasionally produce excitation.

Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.

Drug Interactions

MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.

Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, anti-anxiety agents.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term carcinogenic studies have not been done with cyproheptadine.

Cyproheptadine had no effect on fertility in a two-litter study in rats or a two generation study in mice at about 10 times the human dose.

Cyproheptadine did not produce chromosome damage in human lymphocytes or fibroblasts ; high doses (10-M) were cytotoxic. Cyproheptadine did not have any mutagenic effect in the Ames microbial mutagen test; concentrations of above 500 mcg/plate inhibited bacterial growth.

Pregnancy

Reproduction studies have been performed in rabbits, mice and rats at oral or subcutaneous doses up to 32 times the maximum recommended human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to cyproheptadine. Cyproheptadine has been shown to be fetotoxic in rats when given by intraperitoneal injection in doses four times the maximum recommended human oral dose. Two studies in pregnant women, however, have not shown that cyproheptadine increases the risk of abnormalities when administered during the first, second and third trimesters of pregnancy. No teratogenic effects were observed in any of the newborns. Nevertheless, because the studies in humans cannot rule out the possibility of harm, cyproheptadine should be used during pregnancy only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from cyproheptadine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see ).

Pediatric Use

Safety and effectiveness in pediatric patients below the age of two years have not been established. (see , and ).


What are the side effects of CYPROHEPTADINE?

Adverse reactions which have been reported with the use of antihistamines are as follows:

Central Nervous System:

Integumentary:

Special Senses:

Cardiovascular:

Hematologic:

Digestive System:

Genitourinary:

Respiratory:

Miscellaneous:


What should I look out for while using CYPROHEPTADINE?


What might happen if I take too much CYPROHEPTADINE?

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation especially in children. Also, atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing, etc.) as well as gastrointestinal symptoms may occur.

If vomiting has not occurred spontaneously,

If the patient is unable to vomit,

When life threatening CNS signs and symptoms are present, intravenous physostigmine salicylate may be considered. Dosage and frequency of administration are dependent on age, clinical response and recurrence after response. (See package circulars for physostigmine products.)

Saline cathartics,

Stimulants

not

Vasopressors may be used to treat hypotension.

The oral LD of cyproheptadine is 123 mg/kg, and 295 mg/kg in the mouse and rat, respectively.


How should I store and handle CYPROHEPTADINE?

Dispense in a well-closed container as defined in the USP.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].ArrayDispense in a well-closed container as defined in the USP.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].ArrayDispense in a well-closed container as defined in the USP.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].ArrayCyproheptadine Hydrochloride Syrup (Cyproheptadine Hydrochloride Oral Solution, USP) (2 mg/5 mL), a pale yellow, peppermint flavored liquid, is available in the following oral dosage forms:NDC 0121-0788-16 – Bottles of 16 fl oz (473 mL)NDC 0121-4788-05 – 5 mL Unit Dose Cups, 10 cups per trayNDC 0121-4788-10 – 10 mL Unit Dose Cups, 10 cups per trayCyproheptadine Hydrochloride Syrup (Cyproheptadine Hydrochloride Oral Solution, USP) (2 mg/5 mL), a pale yellow, peppermint flavored liquid, is available in the following oral dosage forms:NDC 0121-0788-16 – Bottles of 16 fl oz (473 mL)NDC 0121-4788-05 – 5 mL Unit Dose Cups, 10 cups per trayNDC 0121-4788-10 – 10 mL Unit Dose Cups, 10 cups per trayCyproheptadine Hydrochloride Syrup (Cyproheptadine Hydrochloride Oral Solution, USP) (2 mg/5 mL), a pale yellow, peppermint flavored liquid, is available in the following oral dosage forms:NDC 0121-0788-16 – Bottles of 16 fl oz (473 mL)NDC 0121-4788-05 – 5 mL Unit Dose Cups, 10 cups per trayNDC 0121-4788-10 – 10 mL Unit Dose Cups, 10 cups per trayCyproheptadine Hydrochloride Syrup (Cyproheptadine Hydrochloride Oral Solution, USP) (2 mg/5 mL), a pale yellow, peppermint flavored liquid, is available in the following oral dosage forms:NDC 0121-0788-16 – Bottles of 16 fl oz (473 mL)NDC 0121-4788-05 – 5 mL Unit Dose Cups, 10 cups per trayNDC 0121-4788-10 – 10 mL Unit Dose Cups, 10 cups per tray


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites.

Non-Clinical Toxicology
MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.

Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, anti-anxiety agents.

Cyproheptadine has an atropine-like action and, therefore, should be used with caution in patients with:

History of bronchial asthma

Increased intraocular pressure

Hyperthyroidism

Cardiovascular disease

Hypertension

Adverse reactions which have been reported with the use of antihistamines are as follows:

Central Nervous System:

Integumentary:

Special Senses:

Cardiovascular:

Hematologic:

Digestive System:

Genitourinary:

Respiratory:

Miscellaneous:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).