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Dehydrated Alcohol

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Overview

What is Dehydrated Alcohol?

Dehydrated Alcohol Injection, USP consists of not less than 98% by volume of ethanol (ethyl alcohol). Dehydrated alcohol is hypobaric in relation to the cerebrospinal fluid. It is injected proximate to nerve tissues and into spinal subarachnoid spaces to produce degeneration of nerve function (neurolysis) for control of chronic pain.

The product contains no bacteriostat or antimicrobial agent (other than ethanol) and no added buffer.

Dehydrated alcohol is a clear, colorless liquid miscible with water and has the following structural formula:



What does Dehydrated Alcohol look like?



What are the available doses of Dehydrated Alcohol?

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What should I talk to my health care provider before I take Dehydrated Alcohol?

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How should I use Dehydrated Alcohol?

Dehydrated Alcohol Injection is indicated for therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (ticdouloureux), in patients for whom neurosurgical procedures are contraindicated. Relief of trigeminal neuralgia usually is only temporary. Other conditions for which injection of alcohol has been reported include glossopharyngeal neuralgia, angina pectoris and severe claudication due to peripheral vascular insufficiency.

Alcohol concentrations of 40 to 50% (prepared by appropriate dilution of dehydrated alcohol) have been used for epidural or individual motor nerve injections to control certain manifestations of cerebral palsy and spastic paraplegia. Similar concentrations also have been injected for celiac plexus block to relieve pain of inoperable upper abdominal cancer, and have been injected intra-and subcutaneously for relief of intractable pruritus ani.

The dosage of Dehydrated Alcohol Injection for therapeutic nerve or ganglion block varies from as little as 0.05 to 0.5 mL in trigeminal neuralgia to 0.5 to 1.0 mL per interspace for subarachnoid injections. Doses larger than 1.5 mL are seldom required. All injections should be made slowly and only after all steps have been taken to insure precise placement of the alcohol. A 1.0 mL tuberculin syringe is desirable to facilitate accurate measurement of the dose. Separate needles should be used for injection of successive interspaces or other sites.  Since Dehydrated Alcohol Injection is hypobaric as compared to spinal fluid, proper positioning of the patient is essential to control localization of injections into the subarachnoid space.

When lesser concentrations of alcohol are used, larger volumes are usually injected. A dose of 2 mL of 45% alcohol has been used for injecting individual motor nerves, or from 1.5 to 4.0 mL for epidural injection in children with spastic cerebral palsy; 50 mL of 50% alcohol has been used for celiac plexus blockade.

The LDoral dose in rats is 13.7 g/kg.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See


What interacts with Dehydrated Alcohol?

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What are the warnings of Dehydrated Alcohol?

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What are the precautions of Dehydrated Alcohol?

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What are the side effects of Dehydrated Alcohol?

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What should I look out for while using Dehydrated Alcohol?

Subarachnoid injection of dehydrated alcohol is contraindicated in patients receiving anticoagulants because of the danger of bleeding.

Alcohol is a flammable liquid and should be kept cool and from any heat source. Alcohol injections should be made with care to avoid unwanted tissue necrosis. Proper positioning of the patient is essential to control localization of injections of dehydrated alcohol (which is hypobaric) into the subarachnoid space.


What might happen if I take too much Dehydrated Alcohol?

Excessive or faulty localization of injections may result in unwanted post-injection neuritis and/or tissue necrosis.

In such cases, efforts should be directed toward dilution of deposited alcohol when feasible, relief of pain with analgesics and surgical intervention if indicated.

Hypotension following celiac ganglion injection may be controlled with appropriate vasopressor agents. See and


How should I store and handle Dehydrated Alcohol?

Store in the closed original carton to protect from light until ready for injection. Store in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Discard if frozen. Once removed from the refrigerator, PLEGRIDY should be allowed to warm to room temperature (about 30 minutes) prior to injection. Do not use external heat sources such as hot water to warm PLEGRIDY. If refrigeration is unavailable, PLEGRIDY may be stored between 2°C to 25°C (36°F to 77°F) for a period up to 30 days, protected from light. PLEGRIDY can be removed from, and returned to, a refrigerator if necessary. The total combined time out of refrigeration, within a temperature range of 2°C to 25°C (36°F to 77°F), should not exceed 30 days. Store in the closed original carton to protect from light until ready for injection. Store in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Discard if frozen. Once removed from the refrigerator, PLEGRIDY should be allowed to warm to room temperature (about 30 minutes) prior to injection. Do not use external heat sources such as hot water to warm PLEGRIDY. If refrigeration is unavailable, PLEGRIDY may be stored between 2°C to 25°C (36°F to 77°F) for a period up to 30 days, protected from light. PLEGRIDY can be removed from, and returned to, a refrigerator if necessary. The total combined time out of refrigeration, within a temperature range of 2°C to 25°C (36°F to 77°F), should not exceed 30 days. Store in the closed original carton to protect from light until ready for injection. Store in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Discard if frozen. Once removed from the refrigerator, PLEGRIDY should be allowed to warm to room temperature (about 30 minutes) prior to injection. Do not use external heat sources such as hot water to warm PLEGRIDY. If refrigeration is unavailable, PLEGRIDY may be stored between 2°C to 25°C (36°F to 77°F) for a period up to 30 days, protected from light. PLEGRIDY can be removed from, and returned to, a refrigerator if necessary. The total combined time out of refrigeration, within a temperature range of 2°C to 25°C (36°F to 77°F), should not exceed 30 days. Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09Dehydrated Alcohol Injection, USPNDC 0517-8571-10     1 mL Ampule     Packages of 10NDC 0517-8575-10     5 mL Ampule     Packages of 10Store in a cool place away from any heat source.AMERICANREGENT, INC.SHIRLEY, NY 11967IN8571Rev. 01/09


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Alcohol produces injury to tissue cells by dehydration and precipitation of protoplasm. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Deliberate injury to selected spinal nerves, peripheral nerves, or ganglia by injection of alcohol results in more or less enduring block of sensory, motor and autonomic function.

The injection of alcohol used for therapeutic neurolysis involves amounts too small to produce significant systemic effects of ethanol.

Ninety to 98% of ethyl alcohol that enters the body is completely oxidized.

Non-Clinical Toxicology
Subarachnoid injection of dehydrated alcohol is contraindicated in patients receiving anticoagulants because of the danger of bleeding.

Alcohol is a flammable liquid and should be kept cool and from any heat source. Alcohol injections should be made with care to avoid unwanted tissue necrosis. Proper positioning of the patient is essential to control localization of injections of dehydrated alcohol (which is hypobaric) into the subarachnoid space.

Aminoglutethimide:

Amphotericin B injection and potassium-depleting agents:

Antibiotics:

Anticholinesterases:

Anticoagulants, oral:

Antidiabetics:

Antitubercular drugs:

Cholestyramine:

Cyclosporine:

Digitalis glycosides:

Estrogens, including oral contraceptives:

Hepatic enzyme inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin):

Ketoconazole:

Nonsteroidal anti-inflammatory drugs (NSAIDs):

Skin tests:





Do not administer unless solution is clear and container is intact. Discard unused portion.

It is sometimes advisable to make a trial injection of procaine or other local anesthetic prior to alcohol injection as a means of confirming accurate placement of the needle, and to decrease pain experienced during the procedure.  X-ray visualization for precise placement also may be advisable.

When used for selective sensory block within the subarachnoid space, it is essential to avoid contact of the alcohol with the anterior (motor) roots of the spinal nerve to be treated if motor paralysis is not desired. When peripheral nerves are injected, care should be taken that residual alcohol is not deposited along the needle track or in any other locations where tissue destruction is not wanted. Instances have been reported in which the pain resulting from post-injection neuritis was more severe than that existing before the injection.

The most commonly encountered side effects are post-injection neuritis with persistent pain, hyperesthesia and paresthesia. Subarachnoid neurolysis and lumbar sympathetic block may be followed by motor paralysis, bladder or rectal incontinence and impotence. Severe hypotension may follow celiac ganglion injection. Corneal anesthesia, meningitis or cranial nerve palsy may follow injection of the gasserian ganglion.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).