Disclaimer:
Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.
DEMEROL
Overview
What is DEMEROL?
DEMEROL (meperidine hydrochloride, USP) Injection is an opioid agonist, available for intramuscular, intravenous, or subcutaneous administration. The chemical name is 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-,ethyl ester, hydrochloride. The molecular weight is 283,80. Its molecular formula is CHNO∙HCl, and it has the following chemical structure.
Meperidine hydrochloride is a white crystalline substance with a melting point of 186° C to 189° C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.
DEMEROL INJECTION is available as Injectable, Carpuject Single-dose cartridge with Luer Lock for the Carpuject Syringe System: 25 mg/mL, 50 mg/mL, 75 mg/mL, and 100 mg/mL.
Injectable, Uni-Amp unit dose pak-ampuls: 25 mg/0.5 mL, 50 mg/mL, 75 mg/1.5 mL, 100 mg/2 mL, and 100 mg/mL
Injectable, multiple-dose vials: 1500 mg/30 mL (50 mg/mL) and 2000 mg/20 mL (100 mg/mL), containing 0.1% metacresol as a preservative.
The pH of DEMEROL Injection solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid.
DEMEROL Injection, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.
What does DEMEROL look like?
What are the available doses of DEMEROL?
Injectable, Carpuject Single-dose cartridge with Luer Lock for the Carpuject Syringe System: 25 mg/mL, 50 mg/mL, 75 mg/mL, and 100 mg/mL.
Injectable, Uni-Amp unit dose pak-ampuls: 25 mg/0.5 mL, 50 mg/mL, 75 mg/1.5 mL, 100 mg/2 mL, and 100 mg/mL
Injectable, multiple-dose vials: 1500 mg/30 mL (50 mg/mL) and 2000 mg/20 mL (100 mg/mL), containing 0.1% metacresol as a preservative.
What should I talk to my health care provider before I take DEMEROL?
How should I use DEMEROL?
DEMEROL Injection is indicated for preoperative medication, support of anesthesia, and obstetrical analgesia.
DEMEROL Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals
Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse .
Monitor patients closely for respiratory depression, especially within the first 24–72 hours of initiating therapy and following dosage increases with DEMEROL Injection and adjust the dosage accordingly
Parenteral drug products should be inspected visually for particulate and discoloration prior to administration whenever solution and container permit.
What interacts with DEMEROL?
Sorry No Records found
What are the warnings of DEMEROL?
Sorry No Records found
What are the precautions of DEMEROL?
Sorry No Records found
What are the side effects of DEMEROL?
Sorry No records found
What should I look out for while using DEMEROL?
DEMEROL Injection is contraindicated in patients with:
What might happen if I take too much DEMEROL?
How should I store and handle DEMEROL?
Store Megestrol acetate oral suspension, USP between 20° to 25°C (68° to 77° F) [see USP Controlled Room Temperature]. Dispense in a tight container. Protect from heat.For Parenteral UseSolutions of DEMEROL Injection for parenteral use are clear and colorless and are available as follows:Carpuject are packaged in a Slim-Pak tamper detection package. Note that a needle is not included.For Parenteral UseSolutions of DEMEROL Injection for parenteral use are clear and colorless and are available as follows:Carpuject are packaged in a Slim-Pak tamper detection package. Note that a needle is not included.For Parenteral UseSolutions of DEMEROL Injection for parenteral use are clear and colorless and are available as follows:Carpuject are packaged in a Slim-Pak tamper detection package. Note that a needle is not included.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Meperidine hydrochloride is an opioid agonist with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and sedation.
Non-Clinical Toxicology
DEMEROL Injection is contraindicated in patients with:DEMEROL Injection contains meperidine, a Schedule II controlled substance. As an opioid, DEMEROL Injection exposes users to the risks of addiction, abuse, and misuse []
Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed DEMEROL Injection. Addiction can occur at recommended dosages and if the drug is misused or abused.
Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing DEMEROL Injection, and monitor all patients receiving DEMEROL Injection for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as DEMEROL Injection, but use in such patients necessitates intensive counseling about the risks and proper use of DEMEROL Injection along with intensive monitoring for signs of addiction, abuse, and misuse.
Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing DEMEROL Injection. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity.
Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.
The following serious adverse reactions are described, or described in greater detail, in other sections:
The following adverse reactions associated with the use of meperidine were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
The major hazards of meperidine, as with other opioid analgesics, are respiratory depression and, to a lesser degree, circulatory depression; respiratory arrest, shock, and cardiac arrest have occurred.
The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not experiencing severe pain. In such individuals, lower doses are advisable. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down.
Other adverse reactions include:
Nervous System.
Inadvertent injection about a nerve trunk may result in sensory-motor paralysis which is usually, though not always, transitory.
Gastrointestinal.
Cardiovascular.
see
Genitourinary.
Allergic.
Other.
Serotonin syndrome
Adrenal insufficiency
Androgen deficiency
[
]
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
Review
Read user comments about the side effects, benefits, and effectiveness of losartan oral.
Overall User Ratings
514Total User Reviews
User Reviews
Learn about
User Reviews
Professional
Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
Tips
Interactions
Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).