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clotrimazole and betamethasone dipropionate, zinc oxide

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Overview

What is DermacinRx Therazole Pak?

Clotrimazole and betamethasone dipropionate cream USP, 1%/0.05% (base), contains combinations of clotrimazole USP, an azole antifungal, and betamethasone dipropionate USP, a corticosteroid, for topical use.

Chemically, clotrimazole, USP is 1-(-Chloro-α,α-diphenylbenzyl)imidazole, with the molecular formula CHClN, a molecular weight of 344.84, and the following structural formula:

Clotrimazole, USP is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.

Betamethasone dipropionate, USP has 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the molecular formula CHFO, a molecular weight of 504.59, and the following structural formula:

Betamethasone dipropionate, USP is a white to creamy-white, odorless crystalline powder, insoluble in water.

Each gram of clotrimazole and betamethasone dipropionate cream, USP contains 10 mg clotrimazole, USP and 0.64 mg betamethasone dipropionate, USP (equivalent to 0.5 mg betamethasone), in a white to off-white hydrophilic cream. Inactive ingredients: Ceteareth-30, cetyl alcohol, mineral oil, propylene glycol, purified water, sodium phosphate monobasic monohydrate, stearyl alcohol and white petrolatum; benzyl alcohol as preservative.



What does DermacinRx Therazole Pak look like?



What are the available doses of DermacinRx Therazole Pak?

Cream, 1%/0.05% (base) ()

Each gram of clotrimazole and betamethasone dipropionate cream, contains 10 mg of clotrimazole and 0.64 mg of betamethasone dipropionate, (equivalent to 0.5 mg of betamethasone) ()

What should I talk to my health care provider before I take DermacinRx Therazole Pak?

How should I use DermacinRx Therazole Pak?

cleanse skin with warm water and soap

apply paste to area as needed

for G-tubes, cleanse as above, apply thin layer and secure with drain sponge or product as directed


What interacts with DermacinRx Therazole Pak?

Sorry No Records found


What are the warnings of DermacinRx Therazole Pak?

Sorry No Records found


What are the precautions of DermacinRx Therazole Pak?

Sorry No Records found


What are the side effects of DermacinRx Therazole Pak?

Sorry No records found


What should I look out for while using DermacinRx Therazole Pak?

None.

For external use only


What might happen if I take too much DermacinRx Therazole Pak?

Sorry No Records found


How should I store and handle DermacinRx Therazole Pak?

Store at 20°C to 25°C (68°F to 77°F) [see USP Controlled Room Temperature].Dispense in tight container as defined in the USP, with a child-resistant closure (as required).Store at 20°C to 25°C (68°F to 77°F) [see USP Controlled Room Temperature].Dispense in tight container as defined in the USP, with a child-resistant closure (as required).Clotrimazole and betamethasone dipropionate cream, USP is available as follows:15 gram tube in a carton (NDC 0472-0379-15)45 gram tube in a carton (NDC 0472-0379-45)Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Clotrimazole and betamethasone dipropionate cream, USP is available as follows:15 gram tube in a carton (NDC 0472-0379-15)45 gram tube in a carton (NDC 0472-0379-45)Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Clotrimazole and betamethasone dipropionate cream, USP is available as follows:15 gram tube in a carton (NDC 0472-0379-15)45 gram tube in a carton (NDC 0472-0379-45)Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Clotrimazole and betamethasone dipropionate cream, USP is available as follows:15 gram tube in a carton (NDC 0472-0379-15)45 gram tube in a carton (NDC 0472-0379-45)Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Clotrimazole is an azole antifungal

Betamethasone dipropionate is a corticosteroid. Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action for the treatment of tinea pedis, tinea cruris and tinea corporis is unknown.

Non-Clinical Toxicology
None.

For external use only

No untoward clinical manifestations have been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements.

Clotrimazole and betamethasone dipropionate cream can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency. This may occur during treatment or after withdrawal of treatment. Cushing’s syndrome and hyperglycemia may also occur due to the systemic effect of corticosteroids while on treatment. Factors that predispose a patient to HPA axis suppression include the use of high-potency steroids, large treatment surface areas, prolonged use, use of occlusive dressing, altered skin barrier, liver failure, and young age.

Because of the potential for systemic corticosteroid effects, patients may need to be periodically evaluated for HPA axis suppression. This may be done by using the adrenocorticotropic hormone (ACTH) stimulation test.

In a small trial, clotrimazole and betamethasone dipropionate cream was applied using large dosages, 7 g daily for 14 days (twice a day) to the crural area of normal adult subjects. Three of the 8 normal subjects on whom clotrimazole and betamethasone dipropionate cream was applied exhibited low morning plasma cortisol levels during treatment. One of these subjects had an abnormal cosyntropin test. The effect on morning plasma cortisol was transient and subjects recovered 1 week after discontinuing dosing. In addition, 2 separate trials in pediatric subjects demonstrated adrenal suppression as determined by cosyntropin testing

If HPA axis suppression is documented, gradually withdraw the drug, reduce the frequency of application, or substitute with a less potent corticosteroid.

Pediatric patients may be more susceptible to systemic toxicity due to their larger skin-surface-to-body mass ratios

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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