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Dermazene
Overview
What is Dermazene?
Each gram of Dermazene Cream 1% contains 10 mg of hydrocortisone and 10 mg of iodoquinol in a cream base of purified water, propylene glycol, cerasynt SE, amerchol L101, isopropyl palmitate, cetyl alcohol, arlacel 60, myrj 52, tween 60, sorbic acid, methyl paraben and propyl paraben.
Chemically, hydrocortisone is [Pregn-4-ene-3,20-dione, 11, 17, 21-trihydroxy-(11β)-] with the molecular formula (CHO) and is represented by the following structural formula:
and iodoquinol, 5,7-diiodo-8-quinolinol (CHINO) is represented by the following structure:
Hydrocortisone is an anti-inflammatory and antipruritic agent, while iodoquinol is an antifungal and antibacterial agent.
What does Dermazene look like?
What are the available doses of Dermazene?
Sorry No records found.
What should I talk to my health care provider before I take Dermazene?
Sorry No records found
How should I use Dermazene?
Apply to affected area 3 to 4 times daily in accordance with physician's directions.
What interacts with Dermazene?
Dermazene Cream is contraindicated in those patients with a history of hypersensitivity to hydrocortisone, iodoquinol or any other components of the preparation.
What are the warnings of Dermazene?
Sorry No Records found
What are the precautions of Dermazene?
Sorry No Records found
What are the side effects of Dermazene?
The following local adverse reactions are reported infrequently with topical corticosteroids. These reactions are listed in an approximate decreasing order of occurrence:
What should I look out for while using Dermazene?
Dermazene Cream is contraindicated in those patients with a history of hypersensitivity to hydrocortisone, iodoquinol or any other components of the preparation.
For external use only. Keep away from eyes. If irritation develops, the use of Dermazene Cream should be discontinued and appropriate therapy instituted. Staining of the skin and fabrics may occur. If extensive areas are treated or if the occlusive technique is used, the possibility exists of increased systemic absorption of the corticosteroid, and suitable precautions should be taken. Children may absorb proportionally larger amounts of the corticosteroids and thus be more susceptible to systemic toxicity. Parents of pediatric patients should be advised not to use tightfitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings. Iodoquinol may be absorbed through the skin and interfere with thyroid function tests. If such tests are contemplated, wait at least one month after discontinuance of therapy to perform these tests. The ferric chloride test for phenylketonuria (PKU) can yield a false positive result if iodoquinol is present in the diaper or urine.
Prolonged use may result in overgrowth of non-susceptible organisms requiring appropriate therapy. Keep out of reach of children.
What might happen if I take too much Dermazene?
Sorry No Records found
How should I store and handle Dermazene?
Store at 25°C (77°F); excursions permitted to 15-30°C (5986°F) [see USP Controlled Room Temperature]. CARAFATE (sucralfate) 1g tablets are supplied in bottles of 100 (NDC 58914-171-10). Light pink, scored, oblong tablets are embossed with CARAFATE on one side and 1712 on the other. Rx Only Prescribing Information rev. November 2016 Distributed by:Allergan USA, Inc.Irvine, CA 92612 © 2016 Allergan. All rights reserved. CARAFATE® is a registered trademark of Aptalis Pharma Canada ULC, an Allergan affiliate. CARAFATE (sucralfate) 1g tablets are supplied in bottles of 100 (NDC 58914-171-10). Light pink, scored, oblong tablets are embossed with CARAFATE on one side and 1712 on the other. Rx Only Prescribing Information rev. November 2016 Distributed by:Allergan USA, Inc.Irvine, CA 92612 © 2016 Allergan. All rights reserved. CARAFATE® is a registered trademark of Aptalis Pharma Canada ULC, an Allergan affiliate. CARAFATE (sucralfate) 1g tablets are supplied in bottles of 100 (NDC 58914-171-10). Light pink, scored, oblong tablets are embossed with CARAFATE on one side and 1712 on the other. Rx Only Prescribing Information rev. November 2016 Distributed by:Allergan USA, Inc.Irvine, CA 92612 © 2016 Allergan. All rights reserved. CARAFATE® is a registered trademark of Aptalis Pharma Canada ULC, an Allergan affiliate. CARAFATE (sucralfate) 1g tablets are supplied in bottles of 100 (NDC 58914-171-10). Light pink, scored, oblong tablets are embossed with CARAFATE on one side and 1712 on the other. Rx Only Prescribing Information rev. November 2016 Distributed by:Allergan USA, Inc.Irvine, CA 92612 © 2016 Allergan. All rights reserved. CARAFATE® is a registered trademark of Aptalis Pharma Canada ULC, an Allergan affiliate. CARAFATE (sucralfate) 1g tablets are supplied in bottles of 100 (NDC 58914-171-10). Light pink, scored, oblong tablets are embossed with CARAFATE on one side and 1712 on the other. Rx Only Prescribing Information rev. November 2016 Distributed by:Allergan USA, Inc.Irvine, CA 92612 © 2016 Allergan. All rights reserved. CARAFATE® is a registered trademark of Aptalis Pharma Canada ULC, an Allergan affiliate. CARAFATE (sucralfate) 1g tablets are supplied in bottles of 100 (NDC 58914-171-10). Light pink, scored, oblong tablets are embossed with CARAFATE on one side and 1712 on the other. Rx Only Prescribing Information rev. November 2016 Distributed by:Allergan USA, Inc.Irvine, CA 92612 © 2016 Allergan. All rights reserved. CARAFATE® is a registered trademark of Aptalis Pharma Canada ULC, an Allergan affiliate.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Hydrocortisone has anti-inflammatory, antipruritic and vasoconstrictor properties. The mechanism of anti-inflammatory activity is unclear. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.
Iodoquinol has both antifungal and antibacterial properties.
Non-Clinical Toxicology
Dermazene Cream is contraindicated in those patients with a history of hypersensitivity to hydrocortisone, iodoquinol or any other components of the preparation.For external use only. Keep away from eyes. If irritation develops, the use of Dermazene Cream should be discontinued and appropriate therapy instituted. Staining of the skin and fabrics may occur. If extensive areas are treated or if the occlusive technique is used, the possibility exists of increased systemic absorption of the corticosteroid, and suitable precautions should be taken. Children may absorb proportionally larger amounts of the corticosteroids and thus be more susceptible to systemic toxicity. Parents of pediatric patients should be advised not to use tightfitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings. Iodoquinol may be absorbed through the skin and interfere with thyroid function tests. If such tests are contemplated, wait at least one month after discontinuance of therapy to perform these tests. The ferric chloride test for phenylketonuria (PKU) can yield a false positive result if iodoquinol is present in the diaper or urine.
Prolonged use may result in overgrowth of non-susceptible organisms requiring appropriate therapy. Keep out of reach of children.
The following local adverse reactions are reported infrequently with topical corticosteroids. These reactions are listed in an approximate decreasing order of occurrence:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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