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DesOwen

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Overview

What is DesOwen?

DesOwen Cream 0.05% and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17 [(1-methylethylidene)bis(oxy)]-,(11β,16α)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic agents.

Chemically, desonide is CHO. It has the following structural formula:

Desonide has the molecular weight of 416.51. It is a white to off white odorless powder which is soluble in methanol and practically insoluble in water.

Each gram of DesOwen Cream contains 0.5 mg of desonide in a base of citric acid, emulsifying wax, isopropyl palmitate, polysorbate 60, potassium sorbate, propyl gallate, propylene glycol, purified water, sodium hydroxide, sorbic acid, stearic acid, and synthetic beeswax.

Each gram of DesOwen Lotion contains 0.5 mg of desonide in a base of cetyl alcohol, edetate sodium, glyceryl stearate SE, light mineral oil, methylparaben, propylene glycol, propylparaben, purified water, sodium lauryl sulfate, sorbitan monostearate, and stearyl alcohol. May contain citric acid and/or sodium hydroxide for pH adjustment.



What does DesOwen look like?



What are the available doses of DesOwen?

Sorry No records found.

What should I talk to my health care provider before I take DesOwen?

Sorry No records found

How should I use DesOwen?

DesOwen Cream and Lotion are low to medium potency corticosteroids indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

DesOwen Cream or Lotion should be applied to the affected areas as a thin film two or three times daily depending on the severity of the condition. SHAKE LOTION WELL BEFORE USING.

As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.

DesOwen Cream and Lotion should not be used with occlusive dressings.


What interacts with DesOwen?

Sorry No Records found


What are the warnings of DesOwen?

Sorry No Records found


What are the precautions of DesOwen?

Sorry No Records found


What are the side effects of DesOwen?

In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%.

The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.


What should I look out for while using DesOwen?

DesOwen Cream and Lotion are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.


What might happen if I take too much DesOwen?

Topically applied DesOwen (desonide cream and lotion) Cream and Lotion can be absorbed in sufficient amounts to produce systemic effects (See PRECAUTIONS).


How should I store and handle DesOwen?

DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014DesOwen (desonide cream) Cream 0.05% is supplied in a tube containing:60 g 0299-5770-6015 g 0299-5770-15DesOwen (desonide lotion) Lotion 0.05% is supplied in bottles containing:2 fl oz 0299-5765-024 fl oz 0299-5765-04Storage Conditions:Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177, USAGALDERMA is a registered trademark.P52472-0 Revised: May 2014


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A.

Non-Clinical Toxicology
DesOwen Cream and Lotion are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.





Potassium Supplements and Potassium-Sparing Diuretics:

Oral Anticoagulants:

Lithium:

Gold:





Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors):

The antihypertensive effect of ACE inhibitors, including benazepril, may be attenuated by NSAIDs.

Dual Blockade of the Renin-Angiotensin System (RAS):

Do not co-administer aliskiren with benazepril in patients with diabetes. Avoid use of aliskiren with benazepril in patients with renal impairment (GFR
Other:

The pharmacokinetics of benazepril are not affected by the following drugs: hydrochlorothiazide, furosemide, chlorthalidone, digoxin, propranolol, atenolol, nifedipine, amlodipine, naproxen, acetylsalicylic acid, or cimetidine. Likewise the administration of benazepril does not substantially affect the pharmacokinetics of these medications (cimetidine kinetics were not studied).

Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment.

Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. This may be done by using the ACTH stimulation, A.M. plasma cortisol, and urinary free cortisol tests. Patients receiving superpotent corticosteroids should not be treated for more than 2 weeks at a time and only small areas should be treated at any one time due to the increased risk of HPA axis suppression.

If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of topical corticosteroids. Infrequently, signs and symptoms of glucocorticosteroid insufficiency may occur requiring supplemental systemic corticosteroids. For information on systemic supplementation, see prescribing information for those products.

Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios. (See PRECAUTIONS - Pediatric use).

If irritation develops, DesOwen Cream or Lotion should be discontinued and appropriate therapy instituted. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Such an observation should be corroborated with appropriate diagnostic patch testing.

If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. If a favorable response does not occur promptly, use of DesOwen (desonide cream and lotion) Cream or Lotion should be discontinued until the infection has been adequately controlled.

In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%.

The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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