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Dexferrum

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Overview

What is Dexferrum?

DEXFERRUM (IRON DEXTRAN INJECTION, USP) is a dark brown, slightly viscous sterile liquid complex of ferric oxyhydroxide for intravenous use. Each mL contains: 50 mg elemental iron as an iron dextran complex. Sodium chloride may have been added for tonicity. Water for injection q.s. pH (range 4.5-7.0) adjusted with hydrochloric acid and, if necessary, sodium hydroxide. Sterile, nonpyrogenic.

Therapeutic Class: Hematinic



What does Dexferrum look like?



What are the available doses of Dexferrum?

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What should I talk to my health care provider before I take Dexferrum?

Sorry No records found

How should I use Dexferrum?

Dexferrum is indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible.

Oral iron should be discontinued prior to administration of Dexferrum.


What interacts with Dexferrum?

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What are the warnings of Dexferrum?

Sorry No Records found


What are the precautions of Dexferrum?

Sorry No Records found


What are the side effects of Dexferrum?

Sorry No records found


What should I look out for while using Dexferrum?

Hypersensitivity to the product. All anemias not associated with iron deficiency.


What might happen if I take too much Dexferrum?

Overdosage with iron dextran is unlikely to be associated with any acute manifestations. Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Periodic monitoring of serum ferritin levels may be helpful in recognizing a deleterious progressive accumulation of iron resulting from impaired uptake of iron from the reticuloendothelial system in concurrent medical conditions such as chronic renal failure, Hodgkins disease, and rheumatoid arthritis. The LD of iron dextran is not less than 500 mg/kg in the mouse.


How should I store and handle Dexferrum?

Dexferrum (Iron Dextran Injection) containing 50 mg of elemental iron per mL. Store at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) (See USP Controlled Room Temperature). Dexferrum (Iron Dextran Injection) containing 50 mg of elemental iron per mL. Store at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) (See USP Controlled Room Temperature).


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
Hypersensitivity to the product. All anemias not associated with iron deficiency.

Drug/Laboratory Test Interactions:

The drug may cause falsely elevated values of serum bilirubin and falsely decreased values of serum calcium.

Serum iron determinations (especially by colorimetric assays) may not be meaningful for 3 weeks following the administration of iron dextran.

Serum ferritin peaks approximately 7 to 9 days after an intravenous dose of Dexferrum and slowly returns to baseline after about 3 weeks.

Examination of the bone marrow for iron stores may not be meaningful for prolonged periods following iron dextran therapy because residual iron dextran may remain in the reticuloendothelial cells.

Bone scans with 99m Tc-labeled bone seeking agents, in the presence of high serum ferritin levels or following iron dextran infusions, have been reported to show reduction of bony uptake, marked renal activity, and excessive blood pool and soft tissue accumulation.

General:

Dexferrum should be used with caution in individuals with histories of significant allergies and/or asthma.

Anaphylaxis and other hypersensitivity reactions have been reported after uneventful test doses as well as therapeutic doses of iron dextran injection. Therefore, administer a test dose prior to the first administration of Dexferrum. (See and

Epinephrine should be immediately available in the event of acute hypersensitivity reactions. (Usual adult dose: 0.5 mL of a 1:1000 solution, by subcutaneous or intramuscular injection.) Patients using beta-blocking agents may not respond adequately to epinephrine. Isoproterenol or similar beta-agonist agents may be required in these patients.

Patients with rheumatoid arthritis may have an acute exacerbation of joint pain and swelling following the administration of Dexferrum.

Severe/Fatal:

Cardiovascular:

Dermatologic:

Gastrointestinal:

Hematologic/lymphatic:

Musculoskeletal/soft tissue:

Neurologic:

Respiratory:

Urologic:

Delayed reactions:

Miscellaneous:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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