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Dexmedetomidine Hydrochloride

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Overview

What is Dexmedetomidine Hydrochloride?

Dexmedetomidine hydrochloride injection is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride. Dexmedetomidine hydrochloride has a molecular weight of 236.7 and the empirical formula is CHN•HCl and the structural formula is:

Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1. Its partition coefficient in-octanol: water at pH 7.4 is 2.89.

Dexmedetomidine hydrochloride injection is supplied as a clear, colorless, isotonic solution with a pH of 4.5 to 7.0. Each mL contains 118 mcg of dexmedetomidine hydrochloride equivalent to 100 mcg (0.1 mg) of dexmedetomidine and 9 mg of sodium chloride in water and is to be used after dilution. The solution is preservative-free and contains no additives or chemical stabilizers.



What does Dexmedetomidine Hydrochloride look like?



What are the available doses of Dexmedetomidine Hydrochloride?

Dexmedetomidine Hydrochloride Injection

Dexmedetomidine Hydrochloride Injection, 200 mcg per 2 mL dexmedetomidine (100 mcg per mL) in a glass vial. To be used after dilution.

What should I talk to my health care provider before I take Dexmedetomidine Hydrochloride?

How should I use Dexmedetomidine Hydrochloride?

Dexmedetomidine hydrochloride injection is a relatively selective alpha-adrenergic agonist indicated for:

Individualize and titrate dexmedetomidine hydrochloride injection dosing to desired clinical effect. ()

Administer dexmedetomidine hydrochloride injection using a controlled infusion device. ()

Dilute the 200 mcg per 2 mL (100 mcg per mL) vial contents in 0.9% sodium chloride solution to achieve required concentration (4 mcg per mL) prior to administration. ()


What interacts with Dexmedetomidine Hydrochloride?

Sorry No Records found


What are the warnings of Dexmedetomidine Hydrochloride?

Sorry No Records found


What are the precautions of Dexmedetomidine Hydrochloride?

Sorry No Records found


What are the side effects of Dexmedetomidine Hydrochloride?

Sorry No records found


What should I look out for while using Dexmedetomidine Hydrochloride?

None


What might happen if I take too much Dexmedetomidine Hydrochloride?

The tolerability of dexmedetomidine hydrochloride injection was studied in one study in which healthy adult subjects were administered doses at and above the recommended dose of 0.2 to 0.7 mcg/kg/hr. The maximum blood concentration achieved in this study was approximately 13 times the upper boundary of the therapeutic range. The most notable effects observed in two subjects who achieved the highest doses were first degree atrioventricular block and second degree heart block. No hemodynamic compromise was noted with the atrioventricular block and the heart block resolved spontaneously within one minute.

One patient who received a loading bolus dose of undiluted dexmedetomidine hydrochloride injection (19.4 mcg/kg), had cardiac arrest from which he was successfully resuscitated.


How should I store and handle Dexmedetomidine Hydrochloride?

Topiramate tablets should be stored in tightly-closed containers at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Protect from moisture. Dexmedetomidine Hydrochloride Injection is supplied as follows: Dexmedetomidine Hydrochloride Injection is available in clear glass vials. The strength is based on the dexmedetomidine base. Dexmedetomidine Hydrochloride Injection is supplied as follows: Dexmedetomidine Hydrochloride Injection is available in clear glass vials. The strength is based on the dexmedetomidine base.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Dexmedetomidine is a relatively selective alpha-adrenergic agonist with sedative properties. Alpha selectivity is observed in animals following slow intravenous infusion of low and medium doses (10 to 300 mcg/kg). Both alpha and alpha activity is observed following slow intravenous infusion of high doses (≥1,000 mcg/kg) or with rapid intravenous administration.

Non-Clinical Toxicology
None

See Table 2 for clinically significant drug interactions with diclofenac.

Dexmedetomidine hydrochloride injection should be administered only by persons skilled in the management of patients in the operating room setting. Due to the known pharmacological effects of dexmedetomidine, patients should be continuously monitored while receiving dexmedetomidine hydrochloride injection.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).