dextroamphetamine sulfate

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Overview

What is dextroamphetamine sulfate?

Dextroamphetamine sulfate is the dextro isomer of the compound ,-amphetamine sulfate, a sympathomimetic amine of the amphetamine group. Chemically, dextroamphetamine is -alpha-methylphenethylamine, and is present in all forms of dextroamphetamine sulfate tablets as the neutral sulfate. It has a chemical formula of (CHN)·HS0 and a molecular weight of 368.50.

Structural Formula:

Each tablet, for oral administration, contains dextroamphetamine sulfate, USP 5 mg or 10 mg. Inactive ingredients: D&C Yellow No. 10, FD&C Blue No. 2, FD&C Red No. 40, hydrated alumina, magnesium stearate, microcrystalline cellulose, and stearic acid.

The 5 mg also contains: mannitol, povidone and starch.

The 10 mg also contains: lactose monohydrate, maltodextrin, sodium starch glycolate, and sugar compressible.

What does dextroamphetamine sulfate look like?

What are the available doses of dextroamphetamine sulfate?

Sorry No records found.

What should I talk to my health care provider before I take dextroamphetamine sulfate?

Sorry No records found

How should I use dextroamphetamine sulfate?

Dextroamphetamine sulfate tablets are indicated in:

Amphetamines should be administered at the lowest effective dosage and dosage should be individually adjusted. Late evening doses should be avoided because of the resulting insomnia.

What interacts with dextroamphetamine sulfate?

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What are the warnings of dextroamphetamine sulfate?

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What are the precautions of dextroamphetamine sulfate?

Sorry No Records found

What are the side effects of dextroamphetamine sulfate?

Sorry No records found

What should I look out for while using dextroamphetamine sulfate?

Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma.

Agitated states.

Patients with a history of drug abuse.

During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result).

What might happen if I take too much dextroamphetamine sulfate?

Individual patient response to amphetamines varies widely. While toxic symptoms occasionally occur as an idiosyncrasy at doses as low as 2 mg, they are rare with doses of less than 15 mg; 30 mg can produce severe reactions, yet doses of 400 to 500 mg are not necessarily fatal.

In rats, the oral LD of dextroamphetamine sulfate is 96.8 mg/kg.

Manifestations of acute overdosage with amphetamines include restlessness, tremor, hyperreflexia, rhabdomyolysis, rapid respiration, hyperpyrexia, confusion, assaultiveness, hallucinations, panic states.

Fatigue and depression usually follow the central stimulation.

Cardiovascular effects include arrhythmias, hypertension or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps. Fatal poisoning is usually preceded by convulsions and coma.

How should I store and handle dextroamphetamine sulfate?

Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP] .Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08 Dextroamphetamine sulfate tablets, USP, 5 mg are round, flat-face, bevel edge, orange mottled tablets, debossed "ETHEX" and "311" on one side and bisect on the other side, packaged as follows: NDC 58177-311-04 bottle of 100 tabletsNDC 58177-311-09 bottle of 1000 tablets Dextroamphetamine sulfate tablets, USP 10 mg are round, flat-face, bevel edge, orange mottled tablets debossed "ETHEX" and "312" on one side and double-scored on the other side, packaged as follows: NDC 58177-312-04 bottle of 100 tabletsNDC 58177-312-09 bottle of 1000 tablets Dispense in a tight container as defined in the USP. Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature.] DEA Order Form Required. Manufactured byKV Pharmaceutical Co. for St. Louis, MO 63044 P5557-2 Rev. 04/08

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Amphetamines are non-catecholamine, sympathomimetic amines with CNS stimulant activity. Peripheral actions include elevations of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action.

There is neither specific evidence that clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor conclusive evidence regarding how these effects relate to the condition of the central nervous system.

Non-Clinical Toxicology

Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma.

Agitated states.

Patients with a history of drug abuse.

During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result).

The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage.

Cardiovascular:

Central Nervous System:

Gastrointestinal:

Allergic:

Endocrine:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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