Disclaimer:
Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.
Acetazolamide
Overview
What is Diamox Sequels?
DIAMOX SEQUELS (Acetazolamide Extended-Release Capsules) are an inhibitor of the enzyme carbonic anhydrase.
DIAMOX is a white to faintly yellowish white crystalline, odorless powder, weakly acidic, very slightly soluble in water, and slightly soluble in alcohol. The chemical name for DIAMOX is N-(5-Sulfamoyl-1,3, 4-thiadiazol-2-yl) acetamide and has the following chemical structure:
MW 222.24 CHNOS
DIAMOX SEQUELS are extended-release capsules, for oral administration, each containing 500 mg of acetazolamide and the following inactive ingredients:
Microcrystalline cellulose, sodium lauryl sulfate and talc.
The ingredients in the capsule shell are D&C red no. 28, D&C yellow no. 10, FD&C red no. 40, gelatin and titanium dioxide.
The ingredients in the imprinting ink are D&C yellow no. 10 aluminum lake, FD&C blue no. 1 aluminum lake, FD&C blue no. 2 aluminum lake, FD&C red no. 40 aluminum lake, pharmaceutical glaze, propylene glycol and synthetic iron oxide.
What does Diamox Sequels look like?
What are the available doses of Diamox Sequels?
Sorry No records found.
What should I talk to my health care provider before I take Diamox Sequels?
Sorry No records found
How should I use Diamox Sequels?
For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angleclosure glaucoma where delay of surgery is desired in order to lower intraocular pressure. DIAMOX is also indicated for the prevention or amelioration of symptoms associated with acute mountain sickness despite gradual ascent.
The recommended dosage is 1 capsule (500 mg) two times a day. Usually 1 capsule is administered in the morning and 1 capsule in the evening. It may be necessary to adjust the dose, but it has usually been found that dosage in excess of 2 capsules (1 g) does not produce an increased effect. The dosage should be adjusted with careful individual attention both to symptomatology and intraocular tension. In all cases, continuous supervision by a physician is advisable.
In those unusual instances where adequate control is not obtained by the twice-a-day administration of DIAMOX SEQUELS, the desired control may be established by means of DIAMOX (tablets or parenteral). Use tablets or parenteral in accordance with the more frequent dosage schedules recommended for these dosage forms, such as 250 mg every four hours, or an initial dose of 500 mg followed by 250 mg or 125 mg every four hours, depending on the case in question.
What interacts with Diamox Sequels?
Sorry No Records found
What are the warnings of Diamox Sequels?
Sorry No Records found
What are the precautions of Diamox Sequels?
Sorry No Records found
What are the side effects of Diamox Sequels?
Body as a whole:
Headache, malaise, fatigue, fever, pain at injection site, flushing, growth retardation in children, flaccid paralysis, anaphylaxis.
Digestive:
Gastrointestinal disturbances such as nausea, vomiting, diarrhea.
Hematological/Lymphatic:
Blood dyscrasias such as aplastic anemia, agranulocytosis, leukopenia, thrombocytopenic purpura, melena.
Hepato-biliary disorders:
Abnormal liver function, cholestatic jaundice, hepatic insufficiency, fulminant hepatic necrosis.
Metabolic/Nutritional:
Metabolic acidosis, electrolyte imbalance, including hypokalemia, hyponatremia, osteomalacia with long-term phenytoin therapy, loss of appetite, taste alteration, hyper/hypoglycemia.
Nervous:
Drowsiness, paresthesia (including numbness and tingling of extremities and face), depression, excitement, ataxia, confusion, convulsions, dizziness.
Skin:
Allergic skin reactions including urticaria, photosensitivity, Stevens- Johnson syndrome, toxic epidermal necrolysis.
Special senses:
Hearing disturbances, tinnitus, transient myopia.
Urogenital:
Crystalluria, increased risk of nephrolithiasis with long-term therapy, hematuria, glycosuria, renal failure, polyuria.
What should I look out for while using Diamox Sequels?
Hypersensitivity to acetazolamide or any excipients in the formulation. Since acetazolamide is a sulfonamide derivative, cross sensitivity between acetazolamide, sulfonamides and other sulfonamide derivatives is possible.
Acetazolamide therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. It is contraindicated in patients with cirrhosis because of the risk of development of hepatic encephalopathy.
Long-term administration of DIAMOX is contraindicated in patients with chronic non-congestive angle-closure glaucoma since it may permit organic closure of the angle to occur while the worsening glaucoma is masked by lowered intraocular pressure.
Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, anaphylaxis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Sensitizations may recur when a sulfonamide is readministered irrespective of the route of administration. If signs of hypersensitivity or other serious reactions occur, discontinue use of this drug.
Caution is advised for patients receiving concomitant high-dose aspirin and DIAMOX, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported.
What might happen if I take too much Diamox Sequels?
No specific antidote is known. Treatment should be symptomatic and supportive. Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored. Supportive measures are required to restore electrolyte and pH balance. The acidotic state can usually be corrected by the administration of bicarbonate.
Despite its high intraerythrocytic distribution and plasma protein binding properties, DIAMOX may be dialyzable. This may be particularly important in the management of DIAMOX overdosage when complicated by the presence of renal failure.
How should I store and handle Diamox Sequels?
Keep testosterone topical solution out of reach of children.Store upright at 25°C (77°F). Excursions are permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.Used testosterone topical solution bottles and applicators should be discarded in household trash in a manner that prevents accidental exposure of children or pets.Keep testosterone topical solution out of reach of children.Store upright at 25°C (77°F). Excursions are permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.Used testosterone topical solution bottles and applicators should be discarded in household trash in a manner that prevents accidental exposure of children or pets.Keep testosterone topical solution out of reach of children.Store upright at 25°C (77°F). Excursions are permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.Used testosterone topical solution bottles and applicators should be discarded in household trash in a manner that prevents accidental exposure of children or pets.DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018DIAMOX SEQUELS Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, . Available in bottles of:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Distributed by:TEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. 1/2018
