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Phenoxybenzamine Hydrochloride
Overview
What is Dibenzyline?
Each Dibenzyline capsule, with red cap and body, is imprinted WPC 001 and 10 mg, and contains 10 mg of Phenoxybenzamine Hydrochloride USP. Inactive ingredients consist of D&C Red No. 33, FD&C Red No. 3, FD&C Yellow No. 6, Gelatin NF, and Lactose NF.
Dibenzyline is -(2-Chloroethyl)--(1-methyl-2-phenoxyethyl)benzylamine hydrochloride:
Phenoxybenzamine hydrochloride is a colorless, crystalline powder with a molecular weight of 340.3, which melts between 136° and 141°C. It is soluble in water, alcohol and chloroform; insoluble in ether.
What does Dibenzyline look like?
What are the available doses of Dibenzyline?
Sorry No records found.
What should I talk to my health care provider before I take Dibenzyline?
Sorry No records found
How should I use Dibenzyline?
Dibenzyline is indicated in the treatment of pheochromocytoma,
to control episodes of hypertension and sweating. If tachycardia is excessive,
it may be necessary to use a -blocking
agent concomitantly.
The dosage should be adjusted to fit the needs of each patient. Small initial doses should be increased until the desired effect is obtained or the side effects from blockade become troublesome. . The dosage should be carried to a point where symptomatic relief and/or objective improvement are obtained, but not so high that the side effects from blockade become troublesome.
Initially, 10 mg of Dibenzyline (phenoxybenzamine hydrochloride) twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.
Long-term use of phenoxybenzamine is not recommended (see PRECAUTIONS ).
What interacts with Dibenzyline?
Conditions where a fall in blood pressure may be undesirable; hypersensitivity to the drug or any of its components.
What are the warnings of Dibenzyline?
Sorry No Records found
What are the precautions of Dibenzyline?
General − Administer with caution in patients with marked cerebral or coronary arteriosclerosis or renal damage. Adrenergic blocking effect may aggravate symptoms of respiratory infections.
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Drug Interactions
Dibenzyline (phenoxybenzamine hydrochloride) may interact with compounds that stimulate both and adrenergic receptors (i.e., epinephrine) to produce an exaggerated hypotensive response and tachycardia. (See )
Dibenzyline blocks hyperthermia production by levarterenol, and blocks hypothermia production by reserpine.
Carcinogenesis and Mutagenesis
Case reports of carcinoma in humans after long-term treatment with phenoxybenzamine have been reported. Hence long-term use of phenoxybenzamine is not recommended.
Carefully weigh the benefits and risks before prescribing this drug.
Phenoxybenzamine hydrochloride showed mutagenic activity in the Ames test and mouse lymphoma assay; it did not show mutagenic activity in the micronucleus test in mice. In rats and mice, repeated intraperitoneal administration of phenoxybenzamine hydrochloride (three times per week for up to 52 weeks) resulted in peritoneal sarcomas. Chronic oral dosing in rats (for up to 2 years) produced malignant tumors of the small intestine and non-glandular stomach, as well as ulcerative and/or erosive gastritis of the glandular stomach. Whereas squamous cell carcinomas of the non-glandular stomach were observed at all tested doses of phenoxybenzamine hydrochloride, there was a no-observed-effect-level of 10 mg/kg for tumors (carcinomas and sarcomas) of the small intestine. This dose is, on a body surface area basis, about twice the maximum recommended human dosage of 20 mg b.i.d.
Pregnancy
Adequate reproductive studies in animals have not been performed with Dibenzyline (phenoxybenzamine hydrochloride). It is also not known whether Dibenzyline can cause fetal harm when administered to a pregnant woman. Dibenzyline should be given to a pregnant woman only if clearly needed.
Nursing Mothers
It is not known whether this drug is excreted in human milk.
Because many drugs are excreted in human milk, and because of the potential
for serious adverse reactions from phenoxybenzamine hydrochloride, a decision
should be made whether to discontinue nursing or to discontinue the drug,
taking into account the importance of the drug to the mother.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
What are the side effects of Dibenzyline?
The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency.
Autonomic Nervous System: Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis.
*
Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.
What should I look out for while using Dibenzyline?
Conditions where a fall in blood pressure may be undesirable;
hypersensitivity to the drug or any of its components.
Dibenzyline-induced -adrenergic
blockade leaves -adrenergic receptors unopposed. Compounds that stimulate both types of receptors may, therefore, produce an exaggerated hypotensive
response and tachycardia.
What might happen if I take too much Dibenzyline?
SYMPTOMS − These are largely the result of blocking of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension, resulting in dizziness or fainting; tachycardia, particularly postural; vomiting; lethargy; shock.
How should I store and handle Dibenzyline?
Dibenzyline (phenoxybenzamine hydrochloride) capsules, 10 mg, in bottles of 100 (NDC 59212-001-01).
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Dibenzyline (phenoxybenzamine hydrochloride) is a long-acting, adrenergic, -receptor-blocking agent, which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system.
Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.
The half-life of orally administered phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously administered drug is approximately 24 hours. Demonstrable effects with intravenous administration persist for at least 3 to 4 days, and the effects of daily administration are cumulative for nearly a week.
Non-Clinical Toxicology
Conditions where a fall in blood pressure may be undesirable; hypersensitivity to the drug or any of its components.Dibenzyline-induced -adrenergic blockade leaves -adrenergic receptors unopposed. Compounds that stimulate both types of receptors may, therefore, produce an exaggerated hypotensive response and tachycardia.
Dibenzyline (phenoxybenzamine hydrochloride) may interact with compounds that stimulate both and adrenergic receptors (i.e., epinephrine) to produce an exaggerated hypotensive response and tachycardia. (See )
Dibenzyline blocks hyperthermia production by levarterenol, and blocks hypothermia production by reserpine.
General − Administer with caution in patients with marked cerebral or coronary arteriosclerosis or renal damage. Adrenergic blocking effect may aggravate symptoms of respiratory infections.
The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency.
Autonomic Nervous System: Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis.
*
Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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