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diclofenac sodium

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Overview

What is Diclo Gel 1% with Xrylix Sheets?

VOLTAREN GEL (diclofenac sodium topical gel) is a nonsteroidal anti-inflammatory drug (NSAID) for topical use only. The chemical name is 2-[(2,6-dichlorophenyl)amino]benzene acetic acid, monosodium salt. The molecular weight is 318.14. Its molecular formula is CHClNNaO, and it has the following chemical structure:

It contains the active ingredient, diclofenac sodium, in an opaque, white gel base. Diclofenac sodium is a white to slightly yellow crystalline powder. Diclofenac sodium is a benzeneacetic acid derivative.

The inactive ingredients in VOLTAREN GEL include: carbomer homopolymer Type C, cocoyl caprylocaprate, fragrance, isopropyl alcohol, mineral oil, polyoxyl 20 cetostearyl ether, propylene glycol, purified water, and strong ammonia solution.



What does Diclo Gel 1% with Xrylix Sheets look like?



What are the available doses of Diclo Gel 1% with Xrylix Sheets?

VOLTAREN GEL (diclofenac sodium topical gel), 1%

What should I talk to my health care provider before I take Diclo Gel 1% with Xrylix Sheets?

Pregnancy

Infertility

How should I use Diclo Gel 1% with Xrylix Sheets?

VOLTAREN GEL is indicated for the relief of the pain of osteoarthritis of joints amenable to topical treatment, such as the knees and those of the hands.

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [ ].


What interacts with Diclo Gel 1% with Xrylix Sheets?

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What are the warnings of Diclo Gel 1% with Xrylix Sheets?

Sorry No Records found


What are the precautions of Diclo Gel 1% with Xrylix Sheets?

Sorry No Records found


What are the side effects of Diclo Gel 1% with Xrylix Sheets?

Sorry No records found


What should I look out for while using Diclo Gel 1% with Xrylix Sheets?

VOLTAREN GEL is contraindicated in the following patients:


What might happen if I take too much Diclo Gel 1% with Xrylix Sheets?

Symptoms following acute NSAID overdosages have been typically limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which have been generally reversible with supportive care. Gastrointestinal bleeding has occurred. Hypertension, acute renal failure, respiratory depression, and coma have occurred, but were rare

Manage patients with symptomatic and supportive care following an NSAID overdosage. There are no specific antidotes. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding.

For additional information about overdosage treatment, contact a poison control center (1-800-222-1222).


How should I store and handle Diclo Gel 1% with Xrylix Sheets?

Unopened vials of Gemcitabine for Injection are stable until the expiration date indicated on the package when stored at controlled room temperature 20° to 25°C (68° to 77°F) and that allows for excursions between 15° and 30°C (59° and 86°F) [See USP Controlled Room Temperature] . VOLTAREN GEL (diclofenac sodium topical gel, 1%) is available in tubes containing 100 grams of the topical gel in each tube. Each tube contains diclofenac sodium in a gel base (10 mg of diclofenac sodium per gram of gel or 1%).100 grams tube………………………………NDC 63481-684-473 Pack (3 Tubes containing 100 g each)……..NDC 63481-684-035 Pack (5 Tubes containing 100 g each)……..NDC 63481-684-05     StorageStore at room temperature 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature]. Keep from freezing. Store the dosing card with your VOLTAREN GELVOLTAREN GEL (diclofenac sodium topical gel, 1%) is available in tubes containing 100 grams of the topical gel in each tube. Each tube contains diclofenac sodium in a gel base (10 mg of diclofenac sodium per gram of gel or 1%).100 grams tube………………………………NDC 63481-684-473 Pack (3 Tubes containing 100 g each)……..NDC 63481-684-035 Pack (5 Tubes containing 100 g each)……..NDC 63481-684-05     StorageStore at room temperature 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature]. Keep from freezing. Store the dosing card with your VOLTAREN GELVOLTAREN GEL (diclofenac sodium topical gel, 1%) is available in tubes containing 100 grams of the topical gel in each tube. Each tube contains diclofenac sodium in a gel base (10 mg of diclofenac sodium per gram of gel or 1%).100 grams tube………………………………NDC 63481-684-473 Pack (3 Tubes containing 100 g each)……..NDC 63481-684-035 Pack (5 Tubes containing 100 g each)……..NDC 63481-684-05     StorageStore at room temperature 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature]. Keep from freezing. Store the dosing card with your VOLTAREN GELVOLTAREN GEL (diclofenac sodium topical gel, 1%) is available in tubes containing 100 grams of the topical gel in each tube. Each tube contains diclofenac sodium in a gel base (10 mg of diclofenac sodium per gram of gel or 1%).100 grams tube………………………………NDC 63481-684-473 Pack (3 Tubes containing 100 g each)……..NDC 63481-684-035 Pack (5 Tubes containing 100 g each)……..NDC 63481-684-05     StorageStore at room temperature 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature]. Keep from freezing. Store the dosing card with your VOLTAREN GEL


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Diclofenac has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of VOLTAREN GEL, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Non-Clinical Toxicology
VOLTAREN GEL is contraindicated in the following patients:

Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedating drugs. If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the hypotensive effect of clonidine may be reduced, necessitating an increase in the clonidine dose. If a patient receiving clonidine is also taking neuroleptics, orthostatic regulation disturbances (e.g., orthostatic hypotension, dizziness, fatigue) may be induced or exacerbated.

Monitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g., digitalis, calcium channel blockers and beta-blockers. Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with diltiazem or verapamil.

Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats (see ).

Based on observations in patients in a state of alcoholic delirium it has been suggested that high intravenous doses of clonidine may increase the arrhythmogenic potential (QT-prolongation, ventricular fibrillation) of high intravenous doses of haloperidol. Causal relationship and relevance for clonidine oral tablets have not been established.

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, including myocardial infarction (MI) and stroke, which can be fatal. Based on available data, it is unclear that the risk for CV thrombotic events is similar for all NSAIDs. The relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV disease. However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses.

To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible. Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur.

There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID, such as diclofenac, increases the risk of serious gastrointestinal (GI) events .

Status Post Coronary Artery Bypass Graft (CABG) Surgery

Two large, controlled clinical trials of a COX-2 selective NSAID for the treatment of pain in the first 10-14 days following CABG surgery found an increased incidence of myocardial infarction and stroke. NSAIDs are contraindicated in the setting of CABG .

Post-MI Patients

Observational studies conducted in the Danish National Registry have demonstrated that patients treated with NSAIDs in the post-MI period were at increased risk of reinfarction, CV-related death, and all-cause mortality beginning in the first week of treatment. In this same cohort, the incidence of death in the first year post-MI was 20 per 100 person years in NSAID-treated patients compared to 12 per 100 person years in non-NSAID exposed patients. Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative risk of death in NSAID users persisted over at least the next four years of follow-up.

Avoid the use of VOLTAREN GEL in patients with a recent MI unless the benefits are expected to outweigh the risk of recurrent CV thrombotic events. If VOLTAREN GEL is used in patients with a recent MI, monitor patients for signs of cardiac ischemia.

The following adverse reactions are discussed in greater detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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