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Diphenhydramine

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Overview

What is Diphenhydramine?

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride.  It occurs as a white, crystalline powder, is freely soluble in water and alcohol.

The structural formula is as follows:

C

H

NO•HCl                         M.W. 291.82

Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL.  pH 4.0 to 6.5; sodium hydroxide and/or hydrochloric acid added, if needed, for pH adjustment.



What does Diphenhydramine look like?



What are the available doses of Diphenhydramine?

Sorry No records found.

What should I talk to my health care provider before I take Diphenhydramine?

Sorry No records found

How should I use Diphenhydramine?

Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.

THIS PRODUCT IS FOR INTRAVENOUS OR INTRAMUSCULAR ADMINISTRATION ONLY.

Diphenhydramine hydrochloride in the injectable form is indicated when the oral form is impractical.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.

Pediatric Patients, other than premature infants and neonates:

Adults:


What interacts with Diphenhydramine?

Sorry No Records found


What are the warnings of Diphenhydramine?

Sorry No Records found


What are the precautions of Diphenhydramine?

Sorry No Records found


What are the side effects of Diphenhydramine?

The most frequent adverse reactions are underscored.

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What should I look out for while using Diphenhydramine?

Antihistamines should be used with considerable caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction.

Local necrosis has been associated with the use of subcutaneous or intradermal use of intravenous diphenhydramine hydrochloride.


What might happen if I take too much Diphenhydramine?

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation.  Stimulation is particularly likely in pediatric patients.  Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur.

Stimulants

Vasopressors may be used to treat hypotension.


How should I store and handle Diphenhydramine?

Store the generator and the eluate, Sodium Pertechnetate Tc99m Injection, below 25°C (77°F). Do not freeze.Store the saline eluent vial below 25°C (77°F). Do not freeze.Storage should be in accordance with local regulations for radioactive materials.Store the generator and the eluate, Sodium Pertechnetate Tc99m Injection, below 25°C (77°F). Do not freeze.Store the saline eluent vial below 25°C (77°F). Do not freeze.Storage should be in accordance with local regulations for radioactive materials.Store the generator and the eluate, Sodium Pertechnetate Tc99m Injection, below 25°C (77°F). Do not freeze.Store the saline eluent vial below 25°C (77°F). Do not freeze.Storage should be in accordance with local regulations for radioactive materials.DiphenhydrAMINE Hydrochloride Injection, USP in parenteral form is supplied as:It is supplied as a sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution, and available in packages of 25.The container closure is not made with natural rubber latex.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Protect from light.  Do not freeze. PremierProRx is a registered trademark of Premier, Inc., used under license.DiphenhydrAMINE Hydrochloride Injection, USP in parenteral form is supplied as:It is supplied as a sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution, and available in packages of 25.The container closure is not made with natural rubber latex.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Protect from light.  Do not freeze. PremierProRx is a registered trademark of Premier, Inc., used under license.DiphenhydrAMINE Hydrochloride Injection, USP in parenteral form is supplied as:It is supplied as a sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution, and available in packages of 25.The container closure is not made with natural rubber latex.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Protect from light.  Do not freeze. PremierProRx is a registered trademark of Premier, Inc., used under license.DiphenhydrAMINE Hydrochloride Injection, USP in parenteral form is supplied as:It is supplied as a sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution, and available in packages of 25.The container closure is not made with natural rubber latex.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Protect from light.  Do not freeze. PremierProRx is a registered trademark of Premier, Inc., used under license.DiphenhydrAMINE Hydrochloride Injection, USP in parenteral form is supplied as:It is supplied as a sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution, and available in packages of 25.The container closure is not made with natural rubber latex.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Protect from light.  Do not freeze. PremierProRx is a registered trademark of Premier, Inc., used under license.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects.  Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

Diphenhydramine hydrochloride in the injectable form has a rapid onset of action.  Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of diphenhydramine hydrochloride injection is not available.

Non-Clinical Toxicology
Antihistamines should be used with considerable caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction.

Local necrosis has been associated with the use of subcutaneous or intradermal use of intravenous diphenhydramine hydrochloride.

Potassium-sparing diuretics, angiotensin-converting enzyme inhibitors (see ).

Diphenhydramine hydrochloride has an atropine-like action and, therefore, should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension.  Use with caution in patients with lower respiratory disease including asthma.

The most frequent adverse reactions are underscored.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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