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Disulfiram

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Overview

What is Disulfiram?

Disulfiram is an alcohol antagonist drug.

CHEMICAL NAME:

bis(diethylthiocarbamoyl) disulfide.

STRUCTURAL FORMULA:

Disulfiram occurs as a white to off-white, odorless, and almost tasteless powder, soluble in water to the extent of about 20 mg in 100 mL, and in alcohol to the extent of about 3.8 g in 100 mL.

Each tablet for oral administration contains 250 mg disulfiram, USP. Tablets also contain colloidal silicon dioxide, anhydrous lactose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and stearic acid.



What does Disulfiram look like?



What are the available doses of Disulfiram?

Sorry No records found.

What should I talk to my health care provider before I take Disulfiram?

Sorry No records found

How should I use Disulfiram?

Disulfiram is an aid in the management of selected chronic alcohol patients who to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage.

Disulfiram is not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic.

Disulfiram should never be administered until the patient has abstained from alcohol for at least 12 hours.

Initial Dosage Schedule:

maximum

Maintenance Regimen:

Note:

Duration of Therapy:

Trial with Alcohol:

However, where a test reaction is deemed necessary, the suggested procedure is as follows:After the first one to two weeks' therapy with 500 mg daily, a drink of 15 mL (1/2 oz) of 100 proof whiskey, or equivalent, is taken slowly. This test dose of alcoholic beverage may be repeated once only, so that the total dose does not exceed 30 mL (1 oz) of whiskey. Once a reaction develops, no more alcohol should be consumed. Such tests should be carried out only when the patient is hospitalized, or comparable supervision and facilities, including oxygen, are available.

Management of Disulfiram-Alcohol Reaction:


What interacts with Disulfiram?

Sorry No Records found


What are the warnings of Disulfiram?

Sorry No Records found


What are the precautions of Disulfiram?

Sorry No Records found


What are the side effects of Disulfiram?

Sorry No records found


What should I look out for while using Disulfiram?

Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.g., cough syrups, tonics and the like, should not be given disulfiram.

Disulfiram is contraindicated in the presence of severe myocardial disease or coronary occlusion, psychoses, and hypersensitivity to disulfiram or to other thiuram derivatives used in pesticides and rubber vulcanization.

The patient must be fully informed of the disulfiram-alcohol reaction. He must be strongly cautioned against surreptitious drinking while taking the drug, and he must be fully aware of the possible consequences. He should be warned to avoid alcohol in disguised forms, i.e., in sauces, vinegars, cough mixtures, and even in aftershave lotions and back rubs. He should also be warned that reactions may occur with alcohol up to 14 days after ingesting disulfiram.

The Disulfiram-Alcohol Reaction:   

The intensity of the reaction varies with each individual, but is generally proportional to the amounts of disulfiram and alcohol ingested. Mild reactions may occur in the sensitive individual when the blood alcohol concentration is increased to as little as 5 to 10 mg per 100 mL. Symptoms are fully developed at 50 mg per 100 mL, and unconsciousness usually results when the blood alcohol level reaches 125 to 150 mg.

The duration of the reaction varies from 30 to 60 minutes, to several hours in the more severe cases, or as long as there is alcohol in the blood.

Concomitant Conditions:   


What might happen if I take too much Disulfiram?

No specific information is available on the treatment of overdosage with disulfiram. It is recommended that the physician contact the local Poison Control Center.


How should I store and handle Disulfiram?

Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653Disulfiram Tablets, USP are white, round, unscored tablets debossed 607.Bottle of 100 NDC 47781-607-01Bottle of 30   NDC 47781-607-30Dispense in a tight, light-resistant container as defined in the USP.Store at 20°-25°C (68°-77°F). [See USP Controlled Room Temperature].Manufactured by: Norwich, NY 13815 USADistributed by:      Pine Brook, NJ 07058 USAPI607-01-01Rev. 04/2013PKG01653