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DORIPENEM
Overview
What is DORIPENEM?
Doripenem for Injection (doripenem monohydrate) vials contain 500 mg of doripenem on an anhydrous basis, a white to slightly-yellowish off-white sterile crystalline powder. All references to doripenem activity are expressed in terms of the active doripenem moiety. The powder is constituted for intravenous infusion. The pH of the infusion solution is between 4.5 and 5.5.
Doripenem for Injection is not formulated with any inactive ingredients.
Doripenem for Injection (doripenem monohydrate) is a synthetic broad-spectrum carbapenem antibiotic structurally related to beta-lactam antibiotics. The chemical name for doripenem monohydrate is (4
,5
,6
)-3-[((3
,5
)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl) thio]-6-[(1
)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate.
Its molecular weight is 438.52, and its chemical structure is:
What does DORIPENEM look like?
What are the available doses of DORIPENEM?
250 mg single use vial or 500 mg single use vial of sterile doripenem powder for reconstitution (
)
What should I talk to my health care provider before I take DORIPENEM?
How should I use DORIPENEM?
Doripenem for Injection is indicated as a single agent for the treatment of complicated intra-abdominal infections caused by
and
.
The recommended dosage of Doripenem for Injection is 500 mg administered every 8 hours by intravenous infusion over one hour in patients ≥18 years of age. The recommended dosage and administration by infection is described in Table 1:
What interacts with DORIPENEM?
Sorry No Records found
What are the warnings of DORIPENEM?
Sorry No Records found
What are the precautions of DORIPENEM?
Sorry No Records found
What are the side effects of DORIPENEM?
Sorry No records found
What should I look out for while using DORIPENEM?
Doripenem for Injection is contraindicated in patients with known serious hypersensitivity to doripenem or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams.
What might happen if I take too much DORIPENEM?
In the event of overdose, Doripenem for Injection should be discontinued and general supportive treatment given.
Doripenem can be removed by hemodialysis. In subjects with end-stage renal disease administered Doripenem for Injection 500 mg, the mean total recovery of doripenem and doripenem-M1 in the dialysate following a 4-hour hemodialysis session was 259 mg (52% of the dose). However, no information is available on the use of hemodialysis to treat overdosage.
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How should I store and handle DORIPENEM?
Sorry No Records found
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Doripenem is an antibacterial drug.
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Non-Clinical Toxicology
Doripenem for Injection is contraindicated in patients with known serious hypersensitivity to doripenem or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams.Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.
In a clinical trial of patients with ventilator-associated bacterial pneumonia comparing doripenem to imipenem, more subjects receiving doripenem died 23% (31/135) compared to those receiving imipenem 16.7% (22/132) based on 28-day all-cause mortality in the intent-to-treat (ITT) population. Clinical response rates were also lower in the doripenem arm. Doripenem is not approved for the treatment of ventilator-associated bacterial pneumonia.
The following adverse reactions are discussed in greater detail in other sections of labeling:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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