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Dorzolamide Hydrochloride

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Overview

What is Dorzolamide HCl?

Dorzolamide hydrochloride ophthalmic solution, USP is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.

Dorzolamide hydrochloride, USP is described chemically as: (4)-4-(ethylamino)-5,6-dihydro-6methyl-4-thieno[2,3-]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride, USP is optically active. The specific rotation is

Its empirical formula is CHNOS•HCl and its structural formula is:

Dorzolamide hydrochloride, USP has a molecular weight of 360.9 and a melting point of about 264°C. It is a white to off-white, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.

Dorzolamide hydrochloride sterile ophthalmic solution, USP is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution of dorzolamide hydrochloride. The pH of the solution is approximately 5.6, and the osmolarity is 260-330 mOsM. Each mL of dorzolamide hydrochloride ophthalmic solution, USP 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride, USP). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH) and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.



What does Dorzolamide HCl look like?



What are the available doses of Dorzolamide HCl?

Solution containing 20 mg/mL dorzolamide. ()

What should I talk to my health care provider before I take Dorzolamide HCl?

How should I use Dorzolamide HCl?

Dorzolamide hydrochloride ophthalmic solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

The dose is one drop of dorzolamide hydrochloride ophthalmic solution in the affected eye(s) three times daily. Dorzolamide hydrochloride ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart.


What interacts with Dorzolamide HCl?

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What are the warnings of Dorzolamide HCl?

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What are the precautions of Dorzolamide HCl?

Sorry No Records found


What are the side effects of Dorzolamide HCl?

Sorry No records found


What should I look out for while using Dorzolamide HCl?

Dorzolamide hydrochloride ophthalmic solution is contraindicated in patients who are hypersensitive to any component of this product


What might happen if I take too much Dorzolamide HCl?

Electrolyte imbalance, development of an acidotic state, and possible central nervous system effects may occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.


How should I store and handle Dorzolamide HCl?

Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].FOR YOUR PROTECTION:Keep out of reach of children.Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].FOR YOUR PROTECTION:Keep out of reach of children.Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].FOR YOUR PROTECTION:Keep out of reach of children.Dorzolamide hydrochloride ophthalmic solution, USP is a slightly opalescent, colorless to nearly colorless, slightly viscous solution.Dorzolamide hydrochloride ophthalmic solution, USP 2% is supplied in a natural, LDPE plastic ophthalmic dispenser with a tear-off tamper-evident ring, a natural nozzle and an orange, tamper-evident cap.NDC Storage Store dorzolamide hydrochloride ophthalmic solution, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from light.Dorzolamide hydrochloride ophthalmic solution, USP is a slightly opalescent, colorless to nearly colorless, slightly viscous solution.Dorzolamide hydrochloride ophthalmic solution, USP 2% is supplied in a natural, LDPE plastic ophthalmic dispenser with a tear-off tamper-evident ring, a natural nozzle and an orange, tamper-evident cap.NDC Storage Store dorzolamide hydrochloride ophthalmic solution, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from light.Dorzolamide hydrochloride ophthalmic solution, USP is a slightly opalescent, colorless to nearly colorless, slightly viscous solution.Dorzolamide hydrochloride ophthalmic solution, USP 2% is supplied in a natural, LDPE plastic ophthalmic dispenser with a tear-off tamper-evident ring, a natural nozzle and an orange, tamper-evident cap.NDC Storage Store dorzolamide hydrochloride ophthalmic solution, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from light.Dorzolamide hydrochloride ophthalmic solution, USP is a slightly opalescent, colorless to nearly colorless, slightly viscous solution.Dorzolamide hydrochloride ophthalmic solution, USP 2% is supplied in a natural, LDPE plastic ophthalmic dispenser with a tear-off tamper-evident ring, a natural nozzle and an orange, tamper-evident cap.NDC Storage Store dorzolamide hydrochloride ophthalmic solution, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from light.Dorzolamide hydrochloride ophthalmic solution, USP is a slightly opalescent, colorless to nearly colorless, slightly viscous solution.Dorzolamide hydrochloride ophthalmic solution, USP 2% is supplied in a natural, LDPE plastic ophthalmic dispenser with a tear-off tamper-evident ring, a natural nozzle and an orange, tamper-evident cap.NDC Storage Store dorzolamide hydrochloride ophthalmic solution, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from light.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II), found primarily in red blood cells (RBCs), but also in other tissues. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure (IOP).

Dorzolamide hydrochloride ophthalmic solution contains dorzolamide hydrochloride, an inhibitor of human carbonic anhydrase II. Following topical ocular administration, dorzolamide hydrochloride ophthalmic solution reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.

Non-Clinical Toxicology
Dorzolamide hydrochloride ophthalmic solution is contraindicated in patients who are hypersensitive to any component of this product

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Absorption of tetracyclines is impaired by bismuth subsalicylate.

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity.

Concurrent use of tetracycline may render oral contraceptives less effective.

Drug/Laboratory Test Interactions

False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Array

Dorzolamide hydrochloride ophthalmic solution contains dorzolamide, a sulfonamide; and although administered topically, it is absorbed systemically. Therefore, the same types of adverse reactions that are attributable to sulfonamides may occur with topical administration of dorzolamide hydrochloride ophthalmic solution. Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Sensitization may recur when a sulfonamide is readministered irrespective of the route of administration. If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation .

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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