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Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL

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Overview

What is Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

Dorzolamide hydrochloride ophthalmic solution is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.

Dorzolamide hydrochloride is described chemically as: (4)-4-(ethylamino)-5,6-dihydro-6-methyl-4-thieno[2,3-]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. The specific rotation is Its empirical formula is CHNOS•HCl and its structural formula is:

Dorzolamide hydrochloride has a molecular weight of 360.9 and a melting point of about 264°C. It is a white to off-white, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.

Dorzolamide hydrochloride ophthalmic solution is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution of dorzolamide hydrochloride. The pH of the solution is approximately 5.6, and the osmolarity is 260-330 mOsM. Each mL of dorzolamide hydrochloride ophthalmic solution 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH) and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.



What does Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL look like?



What are the available doses of Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

Solution containing 20 mg/mL dorzolamide. ()

What should I talk to my health care provider before I take Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

How should I use Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

Dorzolamide hydrochloride ophthalmic solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

The dose is one drop of dorzolamide hydrochloride ophthalmic solution in the affected eye(s) three times daily. Dorzolamide hydrochloride ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart.


What interacts with Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

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What are the warnings of Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

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What are the precautions of Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

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What are the side effects of Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

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What should I look out for while using Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

Dorzolamide hydrochloride ophthalmic solution is contraindicated in patients who are hypersensitive to any component of this product .


What might happen if I take too much Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

Electrolyte imbalance, development of an acidotic state, and possible central nervous system effects may occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.


How should I store and handle Dorzolamide Hydrochloride Ophthalmic Solution 2%, 10mL?

Store olanzapine orally disintegrating tablets at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Protect olanzapine orally disintegrating tablets from light and moisture. Store olanzapine orally disintegrating tablets at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Protect olanzapine orally disintegrating tablets from light and moisture. Dorzolamide hydrochloride ophthalmic solution is supplied in a 10 mL white, round low-density polyethylene (LDPE) bottle, with a natural LDPE dropper tip, and orange colored high-density polyethylene (HDPE) eyedropper cap. A white tamper evident overcap is provided. Dorzolamide hydrochloride ophthalmic solution is available as follows:NDC Storage Dorzolamide hydrochloride ophthalmic solution is supplied in a 10 mL white, round low-density polyethylene (LDPE) bottle, with a natural LDPE dropper tip, and orange colored high-density polyethylene (HDPE) eyedropper cap. A white tamper evident overcap is provided. Dorzolamide hydrochloride ophthalmic solution is available as follows:NDC Storage Dorzolamide hydrochloride ophthalmic solution is supplied in a 10 mL white, round low-density polyethylene (LDPE) bottle, with a natural LDPE dropper tip, and orange colored high-density polyethylene (HDPE) eyedropper cap. A white tamper evident overcap is provided. Dorzolamide hydrochloride ophthalmic solution is available as follows:NDC Storage


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II), found primarily in red blood cells (RBCs), but also in other tissues. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure (IOP).

Dorzolamide hydrochloride ophthalmic solution contains dorzolamide hydrochloride, an inhibitor of human carbonic anhydrase II. Following topical ocular administration, dorzolamide hydrochloride ophthalmic solution reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.

Non-Clinical Toxicology
Dorzolamide hydrochloride ophthalmic solution is contraindicated in patients who are hypersensitive to any component of this product .

In controlled trials, terazosin have been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. Terazosin  has also been used in patients on a variety of concomitant therapies; while these were not formal interaction studies, no interactions were observed. Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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