Econazole Nitrate

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Overview

What is Econazole Nitrate?

Econazole Nitrate Cream, 1% contains the antifungal agent, econazole nitrate 1%, in a water-miscible base consisting of pegoxyl 7 stearate, peglicol 5 oleate, mineral oil, benzoic acid, butylated hydroxyanisole, and purified water. The white to off-white soft cream is for topical use only.

Chemically, econazole nitrate is 1-[2-{(4-chloro-phenyl)methoxy}-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate. Its structure is as follows:

What does Econazole Nitrate look like?

What are the available doses of Econazole Nitrate?

Sorry No records found.

What should I talk to my health care provider before I take Econazole Nitrate?

Sorry No records found

How should I use Econazole Nitrate?

Econazole Nitrate Cream, 1% is indicated for topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by and in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.

Sufficient Econazole Nitrate Cream 1% should be applied to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis.

Early relief of symptoms is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun; however, candidal infections and tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence. If a patient shows no clinical improvement after the treatment period, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment.

What interacts with Econazole Nitrate?

Econazole Nitrate Cream, 1% is contraindicated in individuals who have shown hypersensitivity to any of its ingredients.

What are the warnings of Econazole Nitrate?

Remove contact lenses before using.

What are the precautions of Econazole Nitrate?

General:

For external use only. Avoid introduction of Econazole Nitrate Cream into the eyes.

Carcinogenesis, Mutagenesis, and Impairment of Fertility:

Fertility

Reproduction

Pregnancy:

Teratogenic effects-

Pregnancy Category C

Econazole nitrate should be used in the first trimester of pregnancy only when the physician considers it essential to the welfare of the patient. The drug should be used during the second and third trimesters of pregnancy only if clearly needed.

Nursing Mothers:

What are the side effects of Econazole Nitrate?

During clinical trials, approximately 3% of patients treated with econazole nitrate 1% cream reported side effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging and erythema. One case of pruritic rash has also been reported.

What should I look out for while using Econazole Nitrate?

Econazole Nitrate Cream, 1% is contraindicated in individuals who have shown hypersensitivity to any of its ingredients.

Econazole Nitrate Cream, 1% is not for ophthalmic use.

What might happen if I take too much Econazole Nitrate?

Overdosage of econazole nitrate in humans has not been reported to date. In mice, rats, guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and >160 mg/kg, respectively.

How should I store and handle Econazole Nitrate?

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].Keep out of reach of children.Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].Keep out of reach of children.Econazole Nitrate Cream 1% is supplied as follows:NDC 54868-5042-0 30 gram tubeStore Econazole Nitrate 1% Cream below 86°F (30°C).E. FOUGERA & CO.A division of Nycomed US Inc.MELVILLE, NEW YORK 11747I2312A R12/07 #20Relabeling of "Additional Barcode Label" by:Econazole Nitrate Cream 1% is supplied as follows:NDC 54868-5042-0 30 gram tubeStore Econazole Nitrate 1% Cream below 86°F (30°C).E. FOUGERA & CO.A division of Nycomed US Inc.MELVILLE, NEW YORK 11747I2312A R12/07 #20Relabeling of "Additional Barcode Label" by:Econazole Nitrate Cream 1% is supplied as follows:NDC 54868-5042-0 30 gram tubeStore Econazole Nitrate 1% Cream below 86°F (30°C).E. FOUGERA & CO.A division of Nycomed US Inc.MELVILLE, NEW YORK 11747I2312A R12/07 #20Relabeling of "Additional Barcode Label" by:Econazole Nitrate Cream 1% is supplied as follows:NDC 54868-5042-0 30 gram tubeStore Econazole Nitrate 1% Cream below 86°F (30°C).E. FOUGERA & CO.A division of Nycomed US Inc.MELVILLE, NEW YORK 11747I2312A R12/07 #20Relabeling of "Additional Barcode Label" by:Econazole Nitrate Cream 1% is supplied as follows:NDC 54868-5042-0 30 gram tubeStore Econazole Nitrate 1% Cream below 86°F (30°C).E. FOUGERA & CO.A division of Nycomed US Inc.MELVILLE, NEW YORK 11747I2312A R12/07 #20Relabeling of "Additional Barcode Label" by:Econazole Nitrate Cream 1% is supplied as follows:NDC 54868-5042-0 30 gram tubeStore Econazole Nitrate 1% Cream below 86°F (30°C).E. FOUGERA & CO.A division of Nycomed US Inc.MELVILLE, NEW YORK 11747I2312A R12/07 #20Relabeling of "Additional Barcode Label" by:

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Clinical Information

Chemical Structure

No Image found

Clinical Pharmacology

After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. Inhibitory concentrations were achieved in the epidermis and as deep as the middle region of the dermis. Less than 1% of the applied dose was recovered in the urine and feces.

Non-Clinical Toxicology

Econazole Nitrate Cream, 1% is contraindicated in individuals who have shown hypersensitivity to any of its ingredients.

Econazole Nitrate Cream, 1% is not for ophthalmic use.

Specific drug interaction studies have not been conducted with ophthalmic ciprofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

General:

For external use only. Avoid introduction of Econazole Nitrate Cream into the eyes.

During clinical trials, approximately 3% of patients treated with econazole nitrate 1% cream reported side effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging and erythema. One case of pruritic rash has also been reported.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

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