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Elliotts B
Overview
What is Elliotts B?
Elliotts B Solution is a sterile, nonpyrogenic, isotonic solution containing bacteriostatic preservatives. Elliotts B Solution is a diluent for intrathecal administration of methotrexate sodium and cytarabine.
Each 10 mL of Elliotts B Solution contains:
The formulae and molecular weights of the ingredients are:
What does Elliotts B look like?
What are the available doses of Elliotts B?
Sorry No records found.
What should I talk to my health care provider before I take Elliotts B?
Sorry No records found
How should I use Elliotts B?
Elliotts B Solution is indicated as a diluent for the intrathecal administration
of methotrexate sodium and cytarabine for the prevention or treatment of
meningeal leukemia or lymphocytic lymphoma.
See product labeling for
methotrexate sodium and cytarabine.
Elliotts B Solution is intended for intrathecal
administration only. Elliotts B Solution
does not contain antibacterial preservatives and introduction of contaminated
solutions into the cerebrospinal fluid may have extremely serious consequences.
Therefore, administration of intrathecal solutions should be accomplished as
soon as possible after preparation.
A sterile filter-needle should be used to withdraw the
contents of the ampule.
Intrathecal drug products should be inspected visually
for particulate matter and discoloration prior to administration.
What interacts with Elliotts B?
None known.
What are the warnings of Elliotts B?
Rarely, a reversible reduction of the white blood cell count with a primary effect on the granulocytes has been seen. The granulocyte count returned promptly to normal on discontinuance of the drug. Rare cases of granulocytopenia have been reported. In each instance, upon stopping the drug, the white cell count returned to normal. Reversible thrombocytopenia has occurred rarely.
What are the precautions of Elliotts B?
General
Particular attention should be taken to assure
the maintenance of sterile technique throughout the procedure. (See .)
Carcinogenesis, Mutagenesis, Impairment of Fertility
No standard mutagenicity or carcinogenicity studies
have been conducted with Elliotts B Solution.
Usage in Pregnancy
All components of Elliotts B Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B Solution.
What are the side effects of Elliotts B?
Sorry No records found
What should I look out for while using Elliotts B?
None known.
Intrathecal administration of drugs such as methotrexate
sodium and cytarabine should be performed by personnel skilled in the
technique of lumbar puncture under the supervision of a physician who is
experienced in the use of cancer chemotherapeutic agents. The labeling for
methotrexate sodium and cytarabine should be consulted.
What might happen if I take too much Elliotts B?
Elliotts B Solution is a diluent. In the event of a drug,
fluid or solute overload following administration, evaluate the patient's
condition, and institute appropriate corrective treatment. (See product
labeling for methotrexate sodium and cytarabine.)
How should I store and handle Elliotts B?
NINLARO is cytotoxic. Capsules should not be opened or crushed. Direct contact with the capsule contents should be avoided. In case of capsule breakage, avoid direct contact of capsule contents with the skin or eyes. If contact occurs with the skin, wash thoroughly with soap and water. If contact occurs with the eyes, flush thoroughly with water.Any unused medicinal product or waste material should be disposed in accordance with local requirements.NINLARO is cytotoxic. Capsules should not be opened or crushed. Direct contact with the capsule contents should be avoided. In case of capsule breakage, avoid direct contact of capsule contents with the skin or eyes. If contact occurs with the skin, wash thoroughly with soap and water. If contact occurs with the eyes, flush thoroughly with water.Any unused medicinal product or waste material should be disposed in accordance with local requirements.Elliotts B Solution is available in single-use clear glass ampules, packaged 10 ampules per box. Store at controlled room temperature, 20º-25ºC (68º-77ºF) [See USP]. Discard unused portion. Use only if solution is clear and ampule is intact. Lukare Medical, LLCScotch Plains, NJ 070761-855-752-9317www.elliottsbsolution.com
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Elliotts B Solution provides a buffered salt solution for use as a diluent for the intrathecal
administration of methotrexate sodium and cytarabine. It has been demonstrated
that Elliotts B Solution is comparable to cerebrospinal fluid in pH,
electrolyte composition, glucose content, and osmolarity:
Comparison of Electrolyte Composition, pH and Nonelectrolytic Constituents of Elliotts B Solution and CSF
The approximate buffer capacity of Elliotts B
Solution is 1.1 X 10 equivalents when the challenge solution is
0.01 N HCl and 7.8 X 10 equivalents when the challenge solution is
0.01 N NaOH.
Compatibility studies with methotrexate sodium
and cytarabine indicate these drugs are physically compatible with Elliotts B
Solution.
Non-Clinical Toxicology
None known.Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. The labeling for methotrexate sodium and cytarabine should be consulted.
Cabergoline should not be administered concurrently with D-antagonists, such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide.
Adverse reactions may occur with any given intrathecal injection due to the chemotherapy or the technique of intrathecal administration. (See product labeling for methotrexate sodium and cytarabine.)
Preservative-free methotrexate sodium and cytarabine should be used to minimize adverse reactions due to preservatives.
If an adverse reaction does occur, discontinue the administration, evaluate the patient, institute appropriate therapeutic countermeasures and, if possible, save the remainder of the unused solution(s) for examination.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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