ENBREL

Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

Overview

What is ENBREL?

Etanercept, a tumor necrosis factor (TNF) blocker, is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the C2domain, theC3 domain and hinge region, but not the C1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons.

Enbrel (etanercept) Injection in the single-dose prefilled syringe and thesingle-dose prefilled SureClick autoinjector is clear and colorless, sterile, preservative-free solution, and is formulated at pH 6.3 ± 0.2.

Enbrel (etanercept) for Injection is supplied in a multiple-dose vial as a sterile, white, preservative-free, lyophilized powder. Reconstitution with 1 mL of the supplied Sterile Bacteriostatic Water for Injection, USP (containing 0.9% benzyl alcohol) yields a multiple-dose, clear, and colorless solution 1 mL containing 25 mg of Enbrel, with a pH of 7.4 ± 0.3.

Enbrel (etanercept) Injection in the Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector is clear and colorless, sterile, preservative-free solution, and is formulated at pH 6.3 ± 0.2.

What does ENBREL look like?

What are the available doses of ENBREL?

What should I talk to my health care provider before I take ENBREL?

How should I use ENBREL?

Enbrel is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis (RA). Enbrel can be initiated in combination with methotrexate (MTX) or used alone.

Enbrel is administered by subcutaneous injection.

See the Enbrel (etanercept) “Instructions for Use” insert for detailed information on injection site selection and dose administration .

Adult R

heumatoid

A

rthritis

, A

nkylosing

S

pondylitis

, and Psoriatic Arthritis Patients

Methotrexate, glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs), or analgesics may be continued during treatment with Enbrel.

Based on a study of 50 mg Enbrel twice weekly in patients with RA that suggested higher incidence of adverse reactions but similar American College of Rheumatology (ACR) response rates, doses higher than 50 mg per week are not recommended.

Adult Plaque Psoriasis Patients

In addition to the 50 mg twice weekly recommended starting dose, starting doses of 25 mg or 50 mg per week were shown to be efficacious. The proportion of responders was related to Enbreldosage .

What interacts with ENBREL?

Sorry No Records found

What are the warnings of ENBREL?

Sorry No Records found

What are the precautions of ENBREL?

Sorry No Records found

What are the side effects of ENBREL?

Sorry No records found

What should I look out for while using ENBREL?

What might happen if I take too much ENBREL?

No dose-limiting toxicities have been observed during clinical trials of Enbrel. Single IV doses up to 60 mg/m (approximately twice the recommended dose) have been administered to healthy volunteers in an endotoxemia study without evidence of dose-limiting toxicities.

How should I store and handle ENBREL?

Store at room temperature 68°F to 77°F (20°C to 25°C); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not store unpouched. Apply immediately upon removal from the protective pouch.Used transdermal systems still contain active hormone. To discard, fold the sticky side of the transdermal system together, place it in a sturdy child-proof container, and place this container in the trash. Used transdermal systems should not be flushed in the toilet.Store at room temperature 68°F to 77°F (20°C to 25°C); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not store unpouched. Apply immediately upon removal from the protective pouch.Used transdermal systems still contain active hormone. To discard, fold the sticky side of the transdermal system together, place it in a sturdy child-proof container, and place this container in the trash. Used transdermal systems should not be flushed in the toilet.Store at room temperature 68°F to 77°F (20°C to 25°C); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not store unpouched. Apply immediately upon removal from the protective pouch.Used transdermal systems still contain active hormone. To discard, fold the sticky side of the transdermal system together, place it in a sturdy child-proof container, and place this container in the trash. Used transdermal systems should not be flushed in the toilet.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes or two multiple-dose vials of lyophilized Enbrel, when vials are reconstituted and administered as recommended.Enbrel Single-Dose prefilled Syringe, Enbrel Single-Dose prefilled SureClick Autoinjector, and Enbrel Mini Single-Dose prefilled Cartridge (for use with the AutoTouch Reusable Autoinjector only)Enbrel (etanercept) injection is supplied as a clear and colorless sterile, preservative-free solution for subcutaneous administration in single-dose prefilled syringes and an Enbrel single-dose prefilled SureClick autoinjector with a 27-gauge, ½-inch needle. The needle cover of the prefilled syringe and the needle cover within the white cap of the SureClick autoinjector contains dry natural rubber (a derivative of latex).Each Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector contains 1.0 mL of 50 mg/mL of etanercept. The needle cover within the purple cap of the Enbrel Mini single-dose prefilled cartridge contains dry natural rubber (a derivative of latex).The AutoTouch reusable autoinjector contains no drug and must use an Enbrel Mini single-dose prefilled cartridge.Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the carton or barrel/cartridge label. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. The AutoTouch reusable autoinjector should be stored at room temperature. Do not refrigerate the AutoTouch. reusable autoinjector.For convenience, storage of individual single-dose prefilled syringes, SureClick autoinjectors, or Enbrel Mini cartridges at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light and sources of heat. Once a single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the single-dose prefilled syringe, SureClick autoinjector, or Enbrel Mini cartridge should be discarded. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.Enbrel Lyophilized Powder (Recommended for Weight-based Dosing) Enbrel for Injection is supplied as lyophilized powder for reconstitution in a multiple-dose vial. Each vial is supplied in a carton containing four dose trays. Each dose tray contains one 25 mg vial of etanercept lyophilized powder, one diluent syringe (1 mL Sterile Bacteriostatic Water for Injection, USP, containing 0.9% benzyl alcohol), one 27-gauge ½-inch needle, one vial adapter, and one plunger. Each carton contains four “Mixing Date:” stickers. Enbrel should be refrigerated at 36°F to 46°F (2°C to 8°C). Do not use Enbrel beyond the expiration date stamped on the dose tray. DO NOT SHAKE. Store Enbrel in the original carton to protect from light or physical damage. For convenience, storage of an individual dose tray containing Enbrel multiple-dose vial and diluent syringe at room temperature at 68°F to 77°F (20°C to 25°C) for a maximum single period of 14 days is permissible, with protection from light, sources of heat, and humidity. Once the dose tray has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, the dose tray should be discarded. Once a vial has been reconstituted, the solution must be used immediately or may be refrigerated for up to 14 days. Do not store Enbrel in extreme heat or cold. DO NOT FREEZE. Keep out of the reach of children.

Clinical Information

Chemical Structure

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Clinical Pharmacology

TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. It plays an important role in the inflammatory processes of RA, polyarticular JIA, PsA, and AS and the resulting joint pathology. In addition, TNF plays a role in the inflammatory process of PsO. Elevated levels of TNF are found in involved tissues and fluids of patients with RA, JIA, PsA, AS, and PsO.

Two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75), exist naturally as monomeric molecules on cell surfaces and in soluble forms. Biological activity of TNF is dependent upon binding to either cell surface TNFR.

Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind TNF molecules. Etanercept inhibits binding of TNF-α and TNF-β (lymphotoxin alpha [LT-α]) to cell surface TNFRs, rendering TNF biologically inactive. In studies, large complexes of etanercept with TNF-α were not detected and cells expressing transmembrane TNF (that binds Enbrel) are not lysed in the presence or absence of complement.

Non-Clinical Toxicology

Enbrel should not be administered to patients with sepsis.

SERIOUS INFECTIONS

Patients treated with Enbrel are at increased risk for developing serious infections that may lead to hospitalization or death [see Warnings and Precautions (

) and Adverse Reactions (

)]. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.

Enbrel should be discontinued if a patient develops a serious infection or sepsis.

Reported infections include:

The risks and benefits of treatment with Enbrel should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection.

Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with Enbrel, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy.

MALIGNANCIES

Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, including Enbrel.

Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with cefepime because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibiotics. Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide.

Patients treated with Enbrel are at increased risk for developing serious infections involving various organ systems and sites that may lead to hospitalization or death.

Opportunistic infections due to bacterial, mycobacterial, invasive fungal, viral, parasitic, or other opportunistic pathogens including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, legionellosis, listeriosis, pneumocystosis, and tuberculosis have been reported with TNF blockers. Patients have frequently presented with disseminated rather than localized disease.

Treatment with Enbrel should not be initiated in patients with an active infection, including clinically important localized infections. Patients greater than 65 years of age, patients with co-morbid conditions, and/or patients taking concomitant immunosuppressants (such as corticosteroids or methotrexate), may be at greater risk of infection. The risks and benefits of treatment should be considered prior to initiating therapy in patients:

Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with Enbrel.

Enbrel should be discontinued if a patient develops a serious infection or sepsis. A patient who develops a new infection during treatment with Enbrel should be closely monitored, undergo a prompt and complete diagnostic workup appropriate for an immunocompromised patient, and appropriate antimicrobial therapy should be initiated.

Tuberculosis

Cases of reactivation of tuberculosis or new tuberculosis infections have been observed in patients receiving Enbrel, including patients who have previously received treatment for latent or active tuberculosis. Data from clinical trials and preclinical studies suggest that the risk of reactivation of latent tuberculosis infection is lower with Enbrel than with TNF-blocking monoclonal antibodies. Nonetheless, postmarketing cases of tuberculosis reactivation have been reported for TNF blockers, including Enbrel. Tuberculosis has developed in patients who tested negative for latent tuberculosis prior to initiation of therapy. Patients should be evaluated for tuberculosis risk factors and tested for latent infection prior to initiating Enbrel and periodically during therapy. Tests for latent tuberculosis infection may be falsely negative while on therapy with Enbrel.

Treatment of latent tuberculosis infection prior to therapy with TNF-blocking agents has been shown to reduce the risk of tuberculosis reactivation during therapy. Induration of 5 mm or greater with tuberculin skin testing should be considered a positive test result when assessing if treatment for latent tuberculosis is needed prior to initiating Enbrel, even for patients previously vaccinated with Bacille Calmette-Guerin (BCG).

Anti-tuberculosis therapy should also be considered prior to initiation of Enbrel in patients with a past history of latent or active tuberculosis in whom an adequate course of treatment cannot be confirmed, and for patients with a negative test for latent tuberculosis but having risk factors for tuberculosis infection. Consultation with a physician with expertise in the treatment of tuberculosis is recommended to aid in the decision whether initiating anti-tuberculosis therapy is appropriate for an individual patient.

Tuberculosis should be strongly considered in patients who develop a new infection during Enbrel treatment, especially in patients who have previously or recently traveled to countries with a high prevalence of tuberculosis, or who have had close contact with a person with active tuberculosis.

Invasive Fungal Infections

Cases of serious and sometimes fatal fungal infections, including histoplasmosis, have been reported with TNF blockers, including Enbrel. For patients who reside or travel in regions where mycoses are endemic, invasive fungal infection should be suspected if they develop a serious systemic illness. Appropriate empiric anti-fungal therapy should be considered while a diagnostic workup is being performed. Antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. When feasible, the decision to administer empiric anti-fungal therapy in these patients should be made in consultation with a physician with expertise in the diagnosis and treatment of invasive fungal infections and should take into account both the risk for severe fungal infection and the risks of anti-fungal therapy. In 38 Enbrel clinical trials and 4 cohort studies in all approved indications representing 27,169 patient-years of exposure (17,696 patients) from the United States and Canada, no histoplasmosis infections were reported among patients treated with Enbrel.

The following serious adverse reactions are discussed in greater detail in other sections of the labeling:

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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ENBREL

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ENBREL

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