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adapalene and benzoyl peroxide

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Overview

What is EPIDUO?

EPIDUO (adapalene and benzoyl peroxide) gel, 0.1%/2.5% is a white to very pale yellow, opaque gel for topical use containing adapalene 0.1% and benzoyl peroxide 2.5%.

Active: Adapalene, a synthetic retinoid, is a naphthoic acid derivative with retinoid-like properties. The chemical name for adapalene is (6-[3-(1-adamantyl)-4-methoxyphenyl]-2- naphthoic acid). It has the following structural formula:

Adapalene:

Benzoyl Peroxide is a highly lipophilic oxidizing agent that localizes in both bacterial and keratinocyte cell membranes. The chemical name for benzoyl peroxide is dibenzoyl peroxide. It has the following structural formula:

Benzoyl Peroxide:

EPIDUO gel contains the following inactive ingredients: acrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water, and sorbitan oleate.



What does EPIDUO look like?



What are the available doses of EPIDUO?

Each gram of EPIDUO gel contains 1 mg (0.1%) adapalene and 25 mg (2.5%) benzoyl peroxide. ()

What should I talk to my health care provider before I take EPIDUO?

How should I use EPIDUO?

EPIDUO gel is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

For topical use only; EPIDUO gel is not for oral, ophthalmic, or intravaginal use.

Apply a thin film of EPIDUO gel to affected areas of the face and/or trunk once daily after washing. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips and mucous membranes.


What interacts with EPIDUO?

Sorry No Records found


What are the warnings of EPIDUO?

Sorry No Records found


What are the precautions of EPIDUO?

Sorry No Records found


What are the side effects of EPIDUO?

Sorry No records found


What should I look out for while using EPIDUO?

None


What might happen if I take too much EPIDUO?

Sorry No Records found


How should I store and handle EPIDUO?

EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.EPIDUO (adapalene and benzoyl peroxide) gel 0.1% / 2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows:45 gram tube NDC 0299-5908-4545 gram pump NDC 0299-5908-25Storage and handling - Store at 25ºC; excursions permitted to 15º - 30ºC (59º - 86ºF). - Protect from light. - Keep out of reach of children. - Keep away from heat. - Keep tube tightly closed.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Adapalene

Adapalene binds to specific retinoic acid nuclear receptors but does not bind to cytosolic receptor protein. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown.

Benzoyl peroxide

Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects.

Non-Clinical Toxicology
None

Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. Renal function should be carefully monitored, especially if higher dosages of the aminoglycosides are to be administered or if therapy is prolonged, because of the potential nephrotoxicity and ototoxicity of aminoglycoside antibacterial drugs. Nephrotoxicity and ototoxicity were not noted when ceftazidime was given alone in clinical trials.

Chloramphenicol has been shown to be antagonistic to beta-lactam antibacterial drugs, including ceftazidime, based on in vitro studies and time kill curves with enteric gram-negative bacilli. Due to the possibility of antagonism in vivo, particularly when bactericidal activity is desired, this drug combination should be avoided.

In common with other antibacterial drugs, ceftazidime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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