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Fenoglide
Overview
What is Fenoglide?
Fenoglide (fenofibrate) Tablets, is a lipid regulating agent available as
tablets for oral administration. Each tablet contains 40 mg or 120 mg
fenofibrate. The chemical name for fenofibrate is 2-[4-(4-chlorobenzoyl)
phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester with the following
structural formula:
The empirical formula is CHOCl and the molecular weight is
360.83; fenofibrate is insoluble in water. The melting point is 79° to 82°C.
Fenofibrate is a white solid which is stable under ordinary conditions.
Inactive Ingredients: Each tablet contains lactose monohydrate, NF;
Polyethylene Glycol 6000, NF; Poloxamer 188, NF; and magnesium stearate, NF.
What does Fenoglide look like?
What are the available doses of Fenoglide?
What should I talk to my health care provider before I take Fenoglide?
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How should I use Fenoglide?
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What interacts with Fenoglide?
Sorry No Records found
What are the warnings of Fenoglide?
Sorry No Records found
What are the precautions of Fenoglide?
Sorry No Records found
What are the side effects of Fenoglide?
Sorry No records found
What should I look out for while using Fenoglide?
Severe renal dysfunction, including patients receiving dialysis (, )
Active liver disease (, )
Gallbladder disease (, )
Nursing mothers (, )
What might happen if I take too much Fenoglide?
There is no specific treatment for overdose with Fenoglide. General supportive
care of the patient is indicated, including monitoring of vital signs and
observation of clinical status, should an overdose occur. If indicated,
elimination of unabsorbed drug should be achieved by emesis or gastric lavage;
usual precautions should be observed to maintain the airway. Because fenofibrate
is highly bound to plasma proteins, hemodialysis should not be considered.
How should I store and handle Fenoglide?
Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature). PROTECT FROM LIGHT. KEEP TIGHTLY CLOSED. Sarafem is a registered trademark of Eli Lilly and Company. Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [See USP Controlled Room Temperature].
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The effects of fenofibric acid seen in clinical practice have
been explained in transgenic mice and in human hepatocyte cultures by the activation of
peroxisome proliferator activated receptor α (PPARα).
Through this mechanism, fenofibrate increases lipolysis and elimination of
triglyceride-rich particles from plasma by activating lipoprotein lipase and
reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase
activity). The resulting fall in triglycerides produces an alteration in the
size and composition of LDL from small, dense particles (which are thought to be
atherogenic due to their susceptibility to oxidation), to large buoyant
particles. These larger particles have a greater affinity for cholesterol
receptors and are catabolized rapidly. Activation of PPARα also induces an
increase in the synthesis of apoproteins A-I,A-II and HDL-cholesterol.
Fenofibrate also reduces serum uric acid levels in hyperuricemic and normal
individuals by increasing the urinary excretion of uric acid.
Non-Clinical Toxicology
Severe renal dysfunction, including patients receiving dialysis (, )Active liver disease (, )
Gallbladder disease (, )
Nursing mothers (, )
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To report SUSPECTED ADVERSE REACTIONS, contact Sciele Drug Safety Department at 1-800-849-9707 ext. 1454 or FDA at 1-800-FDA-1088 or
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Interactions
Interactions
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