Disclaimer:
Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.
Firazyr
Overview
What is Firazyr?
FIRAZYR (icatibant) is a synthetic decapeptide with five non-proteinogenic amino acids. The chemical structure of icatibant acetate is presented in Figure 1.
Figure 1 Chemical Structure
Chemical name: D-Arginyl-L-arginyl-L-prolyl-L[(4R)-4-hydroxyprolyl]-glycyl-L[3-(2-thienyl)alanyl]-L-seryl-D-(1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl)-L[(3aS,7aS)-octahydroindol-2-ylcarbonyl]-L-arginine, acetate salt
FIRAZYR is provided as a sterile, isotonic, and buffered solution of icatibant acetate in a single-use, prefilled syringe for subcutaneous administration. Each mL of the solution contains 10 mg of icatibant (free base). Each prefilled syringe delivers 3 mL of solution equivalent to a 30 mg icatibant dose. The solution is clear and colorless.
The solution also contains sodium chloride, glacial acetic acid, sodium hydroxide and water for injection with a pH of approximately 5.5. The solution does not contain preservatives.
Pharmacological class: Icatibant is a bradykinin B2 receptor antagonist.
What does Firazyr look like?
What are the available doses of Firazyr?
Injection: 10 mg per mL ()
What should I talk to my health care provider before I take Firazyr?
How should I use Firazyr?
FIRAZYR (icatibant) is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in adults 18 years of age and older.
The recommended dose of FIRAZYR is 30 mg administered by subcutaneous (SC) injection in the abdominal area. Additional doses may be administered at intervals of at least 6 hours if response is inadequate or if symptoms recur. No more than 3 doses may be administered in any 24 hour period.
What interacts with Firazyr?
Sorry No Records found
What are the warnings of Firazyr?
Sorry No Records found
What are the precautions of Firazyr?
Sorry No Records found
What are the side effects of Firazyr?
Sorry No records found
What should I look out for while using Firazyr?
None.
What might happen if I take too much Firazyr?
In a clinical study evaluating a 90 mg dose (30 mg in each of 3 subcutaneous sites), the adverse event profile was similar to that seen with 30 mg administered in a single subcutaneous site.
In another clinical study, a dose of 3.2 mg/kg administered intravenously (approximately 8 times the therapeutic dose for HAE) caused erythema, itching and hypotension in healthy subjects. No therapeutic intervention was necessary.
How should I store and handle Firazyr?
Keep out of the reach of children.Store between 2 - 25° C (36 - 77° F).Do not freeze.Store in carton until time of administration.Keep out of the reach of children.Store between 2 - 25° C (36 - 77° F).Do not freeze.Store in carton until time of administration.Keep out of the reach of children.Store between 2 - 25° C (36 - 77° F).Do not freeze.Store in carton until time of administration.Keep out of the reach of children.Store between 2 - 25° C (36 - 77° F).Do not freeze.Store in carton until time of administration.Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST: Amlodipine Besylate Tablets, USP are available containing amlodipine besylate, USP equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine.The 2.5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5208-77bottles of 90 tabletsNDC 0378-5208-05bottles of 500 tabletsThe 5 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5209-77bottles of 90 tabletsNDC 0378-5209-05bottles of 500 tabletsThe 10 mg tablets are blue, round, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-5210-77bottles of 90 tabletsNDC 0378-5210-05bottles of 500 tabletsStorageStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Icatibant is a competitive antagonist selective for the bradykinin B2 receptor, with an affinity similar to bradykinin. Hereditary angioedema is caused by an absence or dysfunction of C1-esterase-inhibitor, a key regulator of the Factor XII/kallikrein proteolytic cascade that leads to bradykinin production. Bradykinin is a vasodilator which is thought to be responsible for the characteristic HAE symptoms of localized swelling, inflammation, and pain. Icatibant inhibits bradykinin from binding the B2 receptor and thereby treats the clinical symptoms of an acute, episodic attack of HAE.
Non-Clinical Toxicology
None.Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedating drugs. If a patient receiving clonidine is also taking tricyclic antidepressants, the hypotensive effect of clonidine may be reduced, necessitating an increase in the clonidine dose. If a patient receiving clonidine is also taking neuroleptics, orthostatic regulation disturbances (e.g., orthostatic hypotension, dizziness, fatigue) may be induced or exacerbated.
Monitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g., digitalis, calcium channel blockers, and beta-blockers. Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with diltiazem or verapamil.
Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats (see ).
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
Review
Read user comments about the side effects, benefits, and effectiveness of losartan oral.
Overall User Ratings
514Total User Reviews
User Reviews
Learn about
User Reviews
Professional
Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
Tips
Interactions
Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).