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tamsulosin hydrochloride

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Overview

What is Flomax?

Tamsulosin hydrochloride is an antagonist of alpha adrenoceptors in the prostate.

Tamsulosin hydrochloride is (-)-()-5-[2-[[2-(-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white crystalline powder that melts with decomposition at approximately 230°C. It is sparingly soluble in water and methanol, slightly soluble in glacial acetic acid and ethanol, and practically insoluble in ether.

The empirical formula of tamsulosin hydrochloride is CHNOS • HCl. The molecular weight of tamsulosin hydrochloride is 444.98. Its structural formula is:

Each FLOMAX capsule for oral administration contains tamsulosin hydrochloride 0.4 mg, and the following inactive ingredients: methacrylic acid copolymer dispersion, NF; microcrystalline cellulose, NF; triacetin, USP; calcium stearate, NF; talc, USP; FD&C blue No. 2; titanium dioxide; ferric oxide; gelatin, and trace amounts of black edible ink.



What does Flomax look like?



What are the available doses of Flomax?

Capsule: 0.4 mg, olive green and orange hard gelatin, imprinted on one side with Flomax 0.4 mg and on the other side with BI 58

What should I talk to my health care provider before I take Flomax?

How should I use Flomax?

Flomax (tamsulosin hydrochloride) capsules are indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) []. FLOMAX capsules are not indicated for the treatment of hypertension.

FLOMAX capsules 0.4 mg once daily is recommended as the dose for the treatment of the signs and symptoms of BPH. It should be administered approximately one-half hour following the same meal each day.

For those patients who fail to respond to the 0.4 mg dose after 2 to 4 weeks of dosing, the dose of FLOMAX capsules can be increased to 0.8 mg once daily. FLOMAX capsules 0.4 mg should not be used in combination with strong inhibitors of CYP3A4 (e.g., ketoconazole) [].

If FLOMAX capsules administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the 0.4 mg once-daily dose.


What interacts with Flomax?

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What are the warnings of Flomax?

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What are the precautions of Flomax?

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What are the side effects of Flomax?

Sorry No records found


What should I look out for while using Flomax?


What might happen if I take too much Flomax?


How should I store and handle Flomax?

FLOMAX capsules 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with olive green opaque cap and orange opaque body. The capsules are imprinted on one side with Flomax 0.4 mg and on the other side with BI 58.FLOMAX capsules 0.4 mg,Store at 25°C (77°F); excursions permitted to 15°C–30°C (59°F–86°F)Keep FLOMAX capsules and all medicines out of reach of children.FLOMAX capsules 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with olive green opaque cap and orange opaque body. The capsules are imprinted on one side with Flomax 0.4 mg and on the other side with BI 58.FLOMAX capsules 0.4 mg,Store at 25°C (77°F); excursions permitted to 15°C–30°C (59°F–86°F)Keep FLOMAX capsules and all medicines out of reach of children.FLOMAX capsules 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with olive green opaque cap and orange opaque body. The capsules are imprinted on one side with Flomax 0.4 mg and on the other side with BI 58.FLOMAX capsules 0.4 mg,Store at 25°C (77°F); excursions permitted to 15°C–30°C (59°F–86°F)Keep FLOMAX capsules and all medicines out of reach of children.FLOMAX capsules 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with olive green opaque cap and orange opaque body. The capsules are imprinted on one side with Flomax 0.4 mg and on the other side with BI 58.FLOMAX capsules 0.4 mg,Store at 25°C (77°F); excursions permitted to 15°C–30°C (59°F–86°F)Keep FLOMAX capsules and all medicines out of reach of children.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

The symptoms associated with benign prostatic hyperplasia (BPH) are related to bladder outlet obstruction, which is comprised of two underlying components: static and dynamic. The static component is related to an increase in prostate size caused, in part, by a proliferation of smooth muscle cells in the prostatic stroma. However, the severity of BPH symptoms and the degree of urethral obstruction do not correlate well with the size of the prostate. The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck leading to constriction of the bladder outlet. Smooth muscle tone is mediated by the sympathetic nervous stimulation of alpha adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and a reduction in symptoms of BPH.

Tamsulosin, an alpha adrenoceptor blocking agent, exhibits selectivity for alpha receptors in the human prostate. At least three discrete alpha adrenoceptor subtypes have been identified: alpha, alpha, and alpha; their distribution differs between human organs and tissue. Approximately 70% of the alpha receptors in the human prostate are of the alpha subtype.

FLOMAX capsules are not intended for use as an antihypertensive drug.

Non-Clinical Toxicology
The signs and symptoms of orthostasis (postural hypotension, dizziness, and vertigo) were detected more frequently in FLOMAX capsule-treated patients than in placebo recipients. As with other alpha adrenergic blocking agents there is a potential risk of syncope []. Patients beginning treatment with FLOMAX capsules should be cautioned to avoid situations in which injury could result should syncope occur [].

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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