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Fluoroplex
Overview
What is Fluoroplex?
FLUOROPLEX (fluorouracil) 1% Topical Cream is an antineoplastic/antimetabolite product for dermatological use. Fluorouracil has the empirical formula CHFNO and a molecular weight of 130.08. It is sparingly soluble in water and slightly soluble in alcohol. The pH is approximately 8.5.
Structural Formula:
Fluorouracil
Chemical Name:
FLUOROPLEX 1% Topical Cream contains:
Active Ingredient:
Inactive Ingredients:
What does Fluoroplex look like?
What are the available doses of Fluoroplex?
Sorry No records found.
What should I talk to my health care provider before I take Fluoroplex?
Sorry No records found
How should I use Fluoroplex?
FLUOROPLEX Cream is indicated for the topical treatment of multiple actinic (solar) keratoses.
The patient should be instructed to apply sufficient medication to cover the entire face or other affected areas.
Apply medication twice daily with fingertips and wash hands afterwards. A treatment period of 2-6 weeks is usually required.
Increasing the frequency of application and a longer period of administration with FLUOROPLEX Cream may be required on areas other than the head and neck.
When FLUOROPLEX Cream is applied to keratotic skin, a response occurs with the following sequence: erythema, usually followed by scaling, tenderness, erosion, ulceration, necrosis and re-epithelization. When the inflammatory reaction reaches the erosion, ulceration and necrosis stages, the use of the drug should be terminated. Responses may sometimes occur in areas which appear clinically normal. These may be sites of subclinical actinic (solar) keratosis which the medication is affecting.
What interacts with Fluoroplex?
Fluorouracil is contraindicated in women who are or may become pregnant.
This product should not be used by patients who are allergic to any of its components.
What are the warnings of Fluoroplex?
Entacapone can be taken concomitantly with a selective MAO-B inhibitor (e.g., selegiline).
There exists the potential for a delayed hypersensitivity reaction to fluorouracil. Patch testing to prove hypersensitivity may be inconclusive.
If an occlusive dressing is used, there may be an increase in the incidence of inflammatory reactions in the adjacent normal skin.
The patient should avoid prolonged exposure to sunlight or other forms of ultraviolet irradiation during treatment with FLUOROPLEX Cream, as the intensity of the reaction may be increased.
What are the precautions of Fluoroplex?
General:
Information for patients:
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Laboratory Tests:
Pregnancy: Teratogenic Effects: Pregnancy Category X:
Nursing mothers:
Array
Pediatric use:
What are the side effects of Fluoroplex?
Pain, pruritus, burning, irritation, inflammation, allergic contact dermatitis and telangiectasia have been reported. Occasionally, hyperpigmentation and scarring have also been reported.
What should I look out for while using Fluoroplex?
Fluorouracil is contraindicated in women who are or may become pregnant.
This product should not be used by patients who are allergic to any of its components.
There exists the potential for a delayed hypersensitivity reaction to fluorouracil. Patch testing to prove hypersensitivity may be inconclusive.
If an occlusive dressing is used, there may be an increase in the incidence of inflammatory reactions in the adjacent normal skin.
The patient should avoid prolonged exposure to sunlight or other forms of ultraviolet irradiation during treatment with FLUOROPLEX Cream, as the intensity of the reaction may be increased.
What might happen if I take too much Fluoroplex?
Ordinarily, overdosage will not cause acute problems. If FLUOROPLEX Cream accidentally comes in contact with the eye(s), flush the eyes(s) with water or normal saline. If FLUOROPLEX Cream is accidentally ingested, induce emesis and gastric lavage. Administer symptomatic and supportive care as needed.
How should I store and handle Fluoroplex?
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature].Dispense in a tight container [see USP].Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature].Dispense in a tight container [see USP].FLUOROPLEX (fluorouracil) 1% Topical Cream is available in 30 g tubes (NDC 16110-812-30)
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
There is evidence that fluorouracil (or its metabolites) blocks the methylation reaction of deoxyuridylic acid to thymidylic acid. In this fashion, fluorouracil interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA).
Non-Clinical Toxicology
Fluorouracil is contraindicated in women who are or may become pregnant.This product should not be used by patients who are allergic to any of its components.
There exists the potential for a delayed hypersensitivity reaction to fluorouracil. Patch testing to prove hypersensitivity may be inconclusive.
If an occlusive dressing is used, there may be an increase in the incidence of inflammatory reactions in the adjacent normal skin.
The patient should avoid prolonged exposure to sunlight or other forms of ultraviolet irradiation during treatment with FLUOROPLEX Cream, as the intensity of the reaction may be increased.
Caution is advised if primaquine is used concomitantly with other drugs that prolong the QT interval (see , , and ).
General:
Pain, pruritus, burning, irritation, inflammation, allergic contact dermatitis and telangiectasia have been reported. Occasionally, hyperpigmentation and scarring have also been reported.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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