Fosamprenavir Calcium

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Overview

What is Fosamprenavir Calcium?

Fosamprenavir calcium is a prodrug of amprenavir, an inhibitor of HIV protease. The chemical name of fosamprenavir calcium is (3)-tetrahydrofuran-3-yl (1,2)-3-[[(4-aminophenyl) sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy) propylcarbamate monocalcium salt. Fosamprenavir calcium is a single stereoisomer with the (3)(1,2) configuration. It has a molecular formula of CHCaNOPS and a molecular weight of 623.67. It has the following structural formula:

Fosamprenavir calcium is a white to cream colored powder with a solubility of approximately 0.31 mg per mL in water at 25°C.

Fosamprenavir calcium tablets are available for oral administration in a strength of 700 mg of fosamprenavir as fosamprenavir calcium (equivalent to approximately 600 mg of amprenavir). Each 700 mg tablet contains the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, povidone, red iron oxide, silicified microcrystalline cellulose, titanium dioxide and triacetin.

What does Fosamprenavir Calcium look like?

What are the available doses of Fosamprenavir Calcium?

Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.

What should I talk to my health care provider before I take Fosamprenavir Calcium?

How should I use Fosamprenavir Calcium?

Fosamprenavir calcium tablets are indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection.

The following points should be considered when initiating therapy with fosamprenavir calcium tablets plus ritonavir in protease inhibitor-experienced patients:

Fosamprenavir calcium tablets may be taken with or without food.

Higher-than-approved dose combinations of fosamprenavir plus ritonavir are not recommended due to an increased risk of transaminase elevations .

When fosamprenavir is used in combination with ritonavir, prescribers should consult the full prescribing information for ritonavir.

What interacts with Fosamprenavir Calcium?

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What are the warnings of Fosamprenavir Calcium?

Sorry No Records found

What are the precautions of Fosamprenavir Calcium?

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What are the side effects of Fosamprenavir Calcium?

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What should I look out for while using Fosamprenavir Calcium?

Fosamprenavir calcium tablets are contraindicated:

What might happen if I take too much Fosamprenavir Calcium?

In a healthy volunteer repeat-dose pharmacokinetic trial evaluating high-dose combinations of fosamprenavir plus ritonavir, an increased frequency of Grade 2/3 ALT elevations (greater than 2.5 x ULN) was observed with fosamprenavir 1,400 mg twice daily plus ritonavir 200 mg twice daily (4 of 25 subjects). Concurrent Grade 1/2 elevations in AST (greater than 1.25 x ULN) were noted in 3 of these 4 subjects. These transaminase elevations resolved following discontinuation of dosing.

There is no known antidote for fosamprenavir. It is not known whether amprenavir can be removed by peritoneal dialysis or hemodialysis, although it is unlikely as amprenavir is highly protein bound. If overdosage occurs, the patient should be monitored for evidence of toxicity and standard supportive treatment applied as necessary.

How should I store and handle Fosamprenavir Calcium?

RISPERDAL Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and moisture. RISPERDAL 1 mg/mL Oral Solution should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and freezing. RISPERDAL M-TAB Orally Disintegrating Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Keep out of reach of children.RISPERDAL Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and moisture. RISPERDAL 1 mg/mL Oral Solution should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and freezing. RISPERDAL M-TAB Orally Disintegrating Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Keep out of reach of children.RISPERDAL Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and moisture. RISPERDAL 1 mg/mL Oral Solution should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and freezing. RISPERDAL M-TAB Orally Disintegrating Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Keep out of reach of children.RISPERDAL Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and moisture. RISPERDAL 1 mg/mL Oral Solution should be stored at controlled room temperature 15°–25°C (59°–77°F). Protect from light and freezing. RISPERDAL M-TAB Orally Disintegrating Tablets should be stored at controlled room temperature 15°–25°C (59°–77°F). Keep out of reach of children.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.Fosamprenavir Calcium Tablets are available containing 700 mg of fosamprenavir as fosamprenavir calcium.The 700 mg tablets are pink, film-coated, modified capsule shaped, unscored tablets debossed with on one side of the tablet and on the other side. They are available as follows:NDC 0378-3520-91bottles of 60 tabletsNDC 0378-3520-80bottles of 180 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Keep container tightly closed.Dispense in original container.

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Fosamprenavir is an antiviral agent .

Non-Clinical Toxicology

Fosamprenavir calcium tablets are contraindicated:

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.

Ethacrynate sodium may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. Their concurrent use should be avoided.

A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs.

In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when ethacrynate sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Initiation of fosamprenavir/ritonavir, a CYP3A inhibitor, in patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving fosamprenavir/ritonavir, may increase plasma concentrations of medications metabolized by CYP3A. Initiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of fosamprenavir/ritonavir, respectively. These interactions may lead to:

See Table 7 for steps to prevent or manage these possible and known significant drug interactions, including dosing recommendations . Consider the potential for drug interactions prior to and during fosamprenavir/ritonavir therapy; review concomitant medications during fosamprenavir/ritonavir therapy; and monitor for the adverse reactions associated with the concomitant medications .

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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