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GLEOLAN

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Overview

What is GLEOLAN?



What does GLEOLAN look like?



What are the available doses of GLEOLAN?

For oral solution: 1,500 mg ALA HCl lyophilized powder, equivalent to 1,170 mg ALA per vial. The reconstituted ALA HCl solution contains 30 mg per mL and is clear and colorless to slightly yellowish in color.

What should I talk to my health care provider before I take GLEOLAN?

How should I use GLEOLAN?

Gleolan is indicated in patients with glioma [suspected World Health Organization (WHO) Grades III or IV on preoperative imaging] as an adjunct for the visualization of malignant tissue during surgery.

For oral use only

Recommended reconstituted oral dose of Gleolan is 20 mg/kg. ()

Administer Gleolan to patient orally 3 hours (range 2 to 4 hours) before anesthesia. ()

See Full Prescribing Information for reconstitution information. ()

Use appropriate visualization techniques with appropriate surgical microscopes and light source filters. ()


What interacts with GLEOLAN?

Sorry No Records found


What are the warnings of GLEOLAN?

Sorry No Records found


What are the precautions of GLEOLAN?

Sorry No Records found


What are the side effects of GLEOLAN?

Sorry No records found


What should I look out for while using GLEOLAN?

Hypersensitivity to ALA or porphyrins. (, , )

Acute or chronic types of porphyria. ()


What might happen if I take too much GLEOLAN?

Overdosage has been associated with respiratory insufficiency and erythema. In the event of overdose, supportive measures should be provided as necessary, including protection from strong light sources.


How should I store and handle GLEOLAN?

Store at 25 °C (77 °F); excursions permitted to 15-30 °C (59-86 °F). Product: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLEProduct: 63629-1335NDC: 63629-1335-1 10 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-2 30 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-3 20 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-4 60 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-5 4 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-6 5 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-7 100 TABLET, FILM COATED in a BOTTLENDC: 63629-1335-8 6 TABLET, FILM COATED in a BOTTLE


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

ALA occurs endogenously as a metabolite that is formed in the mitochondria from succinyl-CoA and glycine. Exogenous administration of ALA leads to accumulation of the ALA metabolite PpIX in tumor cells. The reason for the accumulation of PpIX in neoplastic brain tissue is not known.

During glioma surgery, Gleolan is used with an operating microscope adapted with a blue emitting light source (power density 40-80 mW/cm) and filters for excitation light of wavelength 375 to 440 nm, and observation at wavelengths of 620 to 710 nm. This allows tumor tissue to be visualized as red fluorescence. Tissue lacking sufficient PpIX concentrations appears blue.

Non-Clinical Toxicology
Hypersensitivity to ALA or porphyrins. (, , )

Acute or chronic types of porphyria. ()

Antipsychotic drugs such as phenothiazines or haloperidol; tricyclic antidepressants .

Due to the risk of phototoxic reactions, do not administer phototoxic drugs for 24 hours during the perioperative period . Reduce exposure to sunlight or room lights for 48 hours after administration of Gleolan.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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