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Humalog

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Overview

What is Humalog?

HUMALOG (insulin lispro injection) is a rapid-acting human insulin analog used to lower blood glucose. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of . Insulin lispro differs from human insulin in that the amino acid proline at position B28 is replaced by lysine and the lysine in position B29 is replaced by proline. Chemically, it is Lys(B28), Pro(B29) human insulin analog and has the empirical formula CHNOS and a molecular weight of 5808, both identical to that of human insulin.

HUMALOG has the following primary structure:

HUMALOG is a sterile, aqueous, clear, and colorless solution. Each milliliter of HUMALOG U-100 contains insulin lispro 100 units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. Each milliliter of HUMALOG U-200 contains insulin lispro 200 units, 16 mg glycerin, 5 mg tromethamine, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.046 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%.



What does Humalog look like?



What are the available doses of Humalog?

HUMALOG 100 units/mL (U-100) is available as: ()

HUMALOG 200 units/mL (U-200) is available as: ()

What should I talk to my health care provider before I take Humalog?

Pediatrics:

8.4

How should I use Humalog?

HUMALOG is a rapid acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus.

See Full Prescribing Information for important administration instructions. (, , , )

Subcutaneous injection: Administer HUMALOG U-100 or U-200 by subcutaneous injection within 15 minutes before a meal or immediately after a meal. ()

Continuous subcutaneous infusion (Insulin Pump): Administer HUMALOG U-100 by continuous subcutaneous infusion using an insulin pump. DO NOT administer HUMALOG U-200 by continuous subcutaneous infusion. ()

Intravenous Infusion: Administer HUMALOG U-100 by intravenous infusion ONLY after dilution and under medical supervision. DO NOT administer HUMALOG U-200 by intravenous infusion. ()

The dosage of HUMALOG must be individualized based on the route of administration and the individual's metabolic needs, blood glucose monitoring results and glycemic control goal. ()

Do not perform dose conversion when using the HUMALOG U-100 or U-200 KwikPens. The dose window shows the number of insulin units to be delivered and no conversion is needed. (, )

Do not mix HUMALOG U-200 with any other insulin. ()


What interacts with Humalog?

Sorry No Records found


What are the warnings of Humalog?

Sorry No Records found


What are the precautions of Humalog?

Sorry No Records found


What are the side effects of Humalog?

Sorry No records found


What should I look out for while using Humalog?

HUMALOG is contraindicated:


What might happen if I take too much Humalog?

Excess insulin administration may cause hypoglycemia and hypokalemia. Mild episodes of hypoglycemia usually can be treated with oral glucose. Adjustments in drug dosage, meal patterns, or exercise may be needed. More severe episodes with coma, seizure, or neurologic impairment may be treated with intramuscular/subcutaneous glucagon or concentrated intravenous glucose. Sustained carbohydrate intake and observation may be necessary because hypoglycemia may recur after apparent clinical recovery. Hypokalemia must be corrected appropriately.


How should I store and handle Humalog?

Do not use after the expiration date. Unopened HUMALOG should be stored in a refrigerator (36° to 46°F [2° to 8°C]), but not in the freezer. Do not use HUMALOG if it has been frozen. In-use HUMALOG vials, cartridges, and HUMALOG KwikPen should be stored at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain HUMALOG. Protect from direct heat and light. See table below: Do not use after the expiration date. Unopened HUMALOG should be stored in a refrigerator (36° to 46°F [2° to 8°C]), but not in the freezer. Do not use HUMALOG if it has been frozen. In-use HUMALOG vials, cartridges, and HUMALOG KwikPen should be stored at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain HUMALOG. Protect from direct heat and light. See table below: Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Clarithromycin extended-release tablets, USP are supplied as yellow, film coated, oval shaped tablets debossed with  and “777” on one side.Bottles of 20 Tablets NDC #68788-6887-2Bottles of 30 Tablets NDC #68788-6887-3Bottles of 60 Tablets NDC #68788-6887-6Bottles of 90 Tablets NDC #68788-6887-9Bottles of 100 Tablets NDC #68788-6887-1Store clarithromycin extended-release tablets, USP at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Regulation of glucose metabolism is the primary activity of insulins and insulin analogs, including insulin lispro. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis.

Non-Clinical Toxicology
HUMALOG is contraindicated:

Many drugs affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to Levothyroxine sodium tablets, USP. In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugs. A listing of drug-thyroidal axis interactions is contained in Table 2.

The list of drug-thyroidal axis interactions in Table 2 may not be comprehensive due to the introduction of new drugs that interact with the thyroidal axis or the discovery of previously unknown interactions. The prescriber should be aware of this fact and should consult appropriate reference sources (e.g., package inserts of newly approved drugs, medical literature) for additional information if a drug-drug interaction with levothyroxine is suspected.









Drug-Food Interactions





Carcinogenesis, Mutagenesis, and Impairment of Fertility

Pregnancy - Category A

Hypothyroidism during pregnancy is associated with a higher rate of complications, including spontaneous abortion, pre-eclampsia, stillbirth and premature delivery. Maternal hypothyroidism may have an adverse effect on fetal and childhood growth and development. During pregnancy, serum T levels may decrease and serum TSH levels increase to values outside the normal range. Since elevations in serum TSH may occur as early as 4 weeks gestation, pregnant women taking Levothyroxine sodium tablets, USP should have their TSH measured during each trimester. An elevated serum TSH level should be corrected by an increase in the dose of Levothyroxine sodium tablets, USP. Since postpartum TSH levels are similar to preconception values, the Levothyroxine sodium tablets, USP dosage should return to the pre-pregnancy dose immediately after delivery. A serum TSH level should be obtained 6-8 weeks postpartum.

Thyroid hormones cross the placental barrier to some extent as evidenced by levels in cord blood of athyreotic fetuses being approximately one-third maternal levels. Transfer of thyroid hormone from the mother to the fetus, however, may not be adequate to prevent hypothyroidism.

Nursing Mothers

HUMALOG KwikPens, cartridges, and reusable pens compatible with Lilly 3 mL cartridges must never be shared between patients, even if the needle is changed. Patients using HUMALOG vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).