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Hydase
Overview
What is Hydase?
Hydase (hyaluronidase injection) is a preparation of purified bovine testicular hyaluronidase, a protein enzyme. The exact chemical structure of this enzyme is unknown.
Hydase (hyaluronidase injection) is supplied as sterile, colorless, odorless, ready for use solution. Each vial contains 150 USP units of hyaluronidase per mL calcium chloride (0.4 mg), edetate disodium (1 mg), sodium chloride (8.5 mg), monobasic sodium phosphate buffer, sodium hydroxide to adjust the pH, and sterile water.
Hydase has an approximate pH of 6.9 and an osmolality of 275 to 305 mOsm.
What does Hydase look like?
What are the available doses of Hydase?
Injection: 150 USP Units/mL in single-dose vials ()
What should I talk to my health care provider before I take Hydase?
Pediatric Use: The dosage of subcutaneous fluids administered is dependent upon the age, weight, and clinical condition of the patient. For premature infants or during the neonatal period, the daily dosage should not exceed 25 mL/kg of body weight, and the rate of administration should not be greater than 2 mL per minute. Special care must be taken in pediatric patients to avoid over hydration by controlling the rate and total volume of the infusion (, )
How should I use Hydase?
Hydase (hyaluronidase injection) is indicated as an adjuvant to increase the absorption and dispersion of other injected drugs.
Do not administer Hydase intravenously because hyaluronidase is enzyme is rapidly inactivated with intravenous administration.
Hydase may be administered for infiltration use, interstitial use, intramuscular use, intraocular use, retrobulbar use, soft tissue use and subcutaneous use.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever the solution and container permit.
Always use aseptic precautions.
What interacts with Hydase?
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What are the warnings of Hydase?
Sorry No Records found
What are the precautions of Hydase?
Sorry No Records found
What are the side effects of Hydase?
Sorry No records found
What should I look out for while using Hydase?
Hypersensitivity ()
What might happen if I take too much Hydase?
Symptoms of toxicity consist of local edema or urticaria, erythema, chills, nausea, vomiting, dizziness, tachycardia, and hypotension. The enzyme should be discontinued and supportive measures initiated immediately.
How should I store and handle Hydase?
StorageStore Naftifine Hydrochloride Cream, 2% at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) .StorageStore Naftifine Hydrochloride Cream, 2% at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) .Hydase (hyaluronidase injection) Bovine is supplied sterile as 150 units/mL bovine of hyaluronidase in a single-dose glass vial containing 1 mL. NDC 17478-560-01 Package of 1 vial.NDC 17478-560-06 Package of 6 vials.NDC 17478-560-10 Package of 10 vials. Not recommended for IV Use. Hydase (hyaluronidase injection) Bovine is supplied sterile as 150 units/mL bovine of hyaluronidase in a single-dose glass vial containing 1 mL. NDC 17478-560-01 Package of 1 vial.NDC 17478-560-06 Package of 6 vials.NDC 17478-560-10 Package of 10 vials. Not recommended for IV Use. Hydase (hyaluronidase injection) Bovine is supplied sterile as 150 units/mL bovine of hyaluronidase in a single-dose glass vial containing 1 mL. NDC 17478-560-01 Package of 1 vial.NDC 17478-560-06 Package of 6 vials.NDC 17478-560-10 Package of 10 vials. Not recommended for IV Use.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Hyaluronidase is a spreading or diffusing substance which modifies the permeability of connective tissue through the hydrolysis of hyaluronic acid, a polysaccharide found in the intercellular ground substance of connective tissue, and of certain specialized tissues, such as the umbilical cord and vitreous humor. Hyaluronic acid is also present in the capsules of type A and C hemolytic streptococci. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and promotes diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
Hyaluronidase cleaves glycosidic bonds of hyaluronic acid and, to a variable degree, some other acid mucopolysaccharides of the connective tissue. The activity is measured by monitoring the decrease in the amount of an insoluble serum albumin-hyaluronic acid complex as the enzyme cleaves the hyaluronic acid component.
Non-Clinical Toxicology
Hypersensitivity ()Alcohol, Ethyl: Hepatotoxicity has occurred in chronic alcoholics following various dose levels (moderate to excessive) of acetaminophen.
Anticholinergics: The onset of acetaminophen effect may be delayed or decreased slightly, but the ultimate pharmacological effect is not significantly affected by anticholinergics.
Oral Contraceptives: Increase in glucuronidation resulting in increased plasma clearance and a decreased half-life of acetaminophen.
Charcoal (Activated): Reduces acetaminophen absorption when administered as soon as possible after overdose.
Beta Blockers (Propanolol): Propranolol appears to inhibit the enzyme systems responsible for the glucuronidation and oxidation of acetaminophen. Therefore, the pharmacologic effects of acetaminophen may be increased.
Loop Diuretics: The effects of the loop diuretic may be decreased because acetaminophen may decrease renal prostaglandin excretion and decrease plasma renin activity.
Lamotrigine: Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.
Probenecid: Probenecid may increase the therapeutic effectiveness of acetaminophen slightly.
Zidovudine: The pharmacologic effects of zidovudine may be decreased because of enhanced non-hepatic or renal clearance of zidovudine.
Hyaluronidase should not be injected into or around an infected or acutely inflamed area because of the danger of spreading a localized infection.
Hyaluronidase should not be used to reduce the swelling of bites or stings.
The most frequently reported adverse experiences have been local injection site reactions.
Hyaluronidase has been reported to enhance the adverse events associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis.
Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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