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Hydrocortisone and Acetic Acid

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Overview

What is Hydrocortisone and Acetic Acid?

Hydrocortisone and Acetic Acid Otic Solution USP, is a solution containing hydrocortisone USP, (1%) and acetic acid USP, (2%), in a propylene glycol vehicle containing propylene glycol diacetate (3%), benzethonium chloride (0.02%), sodium acetate (0.015%), and citric acid (0.2%). The molecular formulas for acetic acid, USP and hydrocortisone, USP are CHO and CHO, with molecular weights of 60.05 and 362.46, respectively. The structural formulas are:

Chemically, hydrocortisone, USP is: Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-(11ß)-.

Acetic Acid, USP

This product is available as a nonaqueous otic solution buffered at pH 2 to 4 for use in the external ear canal.



What does Hydrocortisone and Acetic Acid look like?



What are the available doses of Hydrocortisone and Acetic Acid?

Sorry No records found.

What should I talk to my health care provider before I take Hydrocortisone and Acetic Acid?

Sorry No records found

How should I use Hydrocortisone and Acetic Acid?

For the treatment of superficial infections of the external auditory canal caused by organisms susceptible to the action of the antimicrobial, complicated by inflammation.

Carefully remove all cerumen and debris to allow solution to contact infected surfaces directly. To promote continuous contact, insert a wick of cotton saturated with the solution into the ear canal; the wick may also be saturated after insertion. Instruct the patient to keep the wick in for at least 24 hours and to keep it moist by adding 3 to 5 drops of solution every 4 to 6 hours. The wick may be removed after 24 hours but the patient should continue to instill 5 drops of solution 3 or 4 times daily thereafter, for as long as indicated. In pediatric patients, 3 to 4 drops may be sufficient due to the smaller capacity of the ear canal.


What interacts with Hydrocortisone and Acetic Acid?

Sorry No Records found


What are the warnings of Hydrocortisone and Acetic Acid?

Sorry No Records found


What are the precautions of Hydrocortisone and Acetic Acid?

Sorry No Records found


What are the side effects of Hydrocortisone and Acetic Acid?

Sorry No records found


What should I look out for while using Hydrocortisone and Acetic Acid?

Hypersensitivity to any of the ingredients, herpes simplex, vaccinia and varicella. Perforated tympanic membrane is considered a contraindication to the use of any medication in the external ear canal.

Discontinue promptly if sensitization or irritation occurs.


What might happen if I take too much Hydrocortisone and Acetic Acid?

Sorry No Records found


How should I store and handle Hydrocortisone and Acetic Acid?

ZERBAXA vials should be stored refrigerated at 2 to 8°C (36 to 46°F) and protected from light.The reconstituted solution, once diluted, may be stored for 24 hours at room temperature or for 7 days under refrigeration at 2 to 8° C (36 to 46°F).ZERBAXA vials should be stored refrigerated at 2 to 8°C (36 to 46°F) and protected from light.The reconstituted solution, once diluted, may be stored for 24 hours at room temperature or for 7 days under refrigeration at 2 to 8° C (36 to 46°F).Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077Hydrocortisone and Acetic Acid Otic Solution USP, 1%/2% is available in a 10 mL measured-drop, safety-tip plastic bottle (NDC 45963-412-61).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed.Manufactured by:G&W Laboratories, Inc.111 Coolidge StreetSouth Plainfield, NJ 07080 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USARevised -  March 2016365I602-1180 GW7077


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Acetic acid is anti-bacterial and anti-fungal; hydrocortisone is anti-inflammatory, anti-allergic and anti-pruritic; propylene glycol is hydrophilic and provides a low surface tension; benzethonium chloride is a surface active agent that promotes contact of the solution with tissues.

Non-Clinical Toxicology
Hypersensitivity to any of the ingredients, herpes simplex, vaccinia and varicella. Perforated tympanic membrane is considered a contraindication to the use of any medication in the external ear canal.

Discontinue promptly if sensitization or irritation occurs.

ACE-inhibitors:

Aspirin

Transient stinging or burning may be noted occasionally when the solution is first instilled into the acutely inflamed ear.

Stinging or burning may be noted occasionally; local irritation has occurred very rarely.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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