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Hydroxychloroquine Sulfate

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Overview

What is Hydroxychloroquine Sulfate?

Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl]ethylamino] ethanol sulfate (1:1).

Hydroxychloroquine Sulfate Tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration.

Inactive Ingredients:

Film Coating



What does Hydroxychloroquine Sulfate look like?



What are the available doses of Hydroxychloroquine Sulfate?

Sorry No records found.

What should I talk to my health care provider before I take Hydroxychloroquine Sulfate?

Sorry No records found

How should I use Hydroxychloroquine Sulfate?

Hydroxychloroquine Sulfate Tablets are indicated for the suppressive treatment and treatments of acute attacks of malaria due to , , , and susceptible strains of . It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.


What interacts with Hydroxychloroquine Sulfate?

Use of this drug is contraindicated (1) in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, (2) in patients with known hypersensitivity to 4-aminoquinoline compounds, and (3) for long-term therapy in children.



What are the warnings of Hydroxychloroquine Sulfate?

Sorry No Records found


What are the precautions of Hydroxychloroquine Sulfate?

Sorry No Records found


What are the side effects of Hydroxychloroquine Sulfate?

Sorry No records found


What should I look out for while using Hydroxychloroquine Sulfate?

Use of this drug is contraindicated (1) in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, (2) in patients with known hypersensitivity to 4-aminoquinoline compounds, and (3) for long-term therapy in children.

Hydroxychloroquine Sulfate Tablets are not effective against chloroquine-resistant strains of .

Children are especially sensitive to the 4-aminoquinoline compounds. A number of fatalities have been reported following the accidental ingestion of chloroquine, sometimes in relatively small doses (0.75 g or 1 g in one 3-year-old child). Patients should be strongly warned to keep these drugs out of the reach of children.

Use of Hydroxychloroquine Sulfate Tablets in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. The preparation should not be used in these conditions unless in the judgment of the physician the benefit to the patient outweighs the possible hazard.


What might happen if I take too much Hydroxychloroquine Sulfate?

The 4-aminoquinoline compounds are very rapidly and completely absorbed after ingestion, and in accidental overdosage, or rarely with lower doses in hypersensitive patients, toxic symptoms may occur within 30 minutes. These consist of headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest. Treatment is symptomatic and must be prompt with immediate evacuation of the stomach by emesis (at home, before transportation to the hospital) or gastric lavage until the stomach is completely emptied. If finely powdered, activated charcoal is introduced by the stomach tube, after lavage, and within 30 minutes after ingestion of the tablets, it may inhibit further intestinal absorption of the drug. To be effective, the dose of activated charcoal should be at least five times the estimated dose of hydroxychloroquine ingested. Convulsions, if present, should be controlled before attempting gastric lavage. If due to cerebral stimulation, cautious administration of an ultrashort-acting barbiturate may be tried but, if due to anoxia, it should be corrected by oxygen administration, artificial respiration or, in shock with hypotension, by vasopressor therapy. Because of the importance of supporting respiration, tracheal intubation or tracheostomy, followed by gastric lavage, may also be necessary. Exchange transfusions have been used to reduce the level of 4-aminoquinoline drug in the blood.

A patient who survives the acute phase and is asymptomatic should be closely observed for at least six hours. Fluids may be forced, and sufficient ammonium chloride (8 g daily in divided doses for adults) may be administered for a few days to acidify the urine to help promote urinary excretion in cases of both overdosage and sensitivity.


How should I store and handle Hydroxychloroquine Sulfate?

StorageStore Pantoprazole sodium delayed-release tablets at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature.]StorageStore Pantoprazole sodium delayed-release tablets at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature.]Hydroxychloroquine Sulfate Tablets are White, Round Tablets; Embossed "WW28". Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base).    Bottles of 100 tablets Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature].Manufactured by: Eatontown, NJ 07724Revised September 2009Hydroxychloroquine Sulfate Tablets are White, Round Tablets; Embossed "WW28". Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base).    Bottles of 100 tablets Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature].Manufactured by: Eatontown, NJ 07724Revised September 2009Hydroxychloroquine Sulfate Tablets are White, Round Tablets; Embossed "WW28". Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base).    Bottles of 100 tablets Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature].Manufactured by: Eatontown, NJ 07724Revised September 2009Hydroxychloroquine Sulfate Tablets are White, Round Tablets; Embossed "WW28". Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base).    Bottles of 100 tablets Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature].Manufactured by: Eatontown, NJ 07724Revised September 2009Hydroxychloroquine Sulfate Tablets are White, Round Tablets; Embossed "WW28". Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base).    Bottles of 100 tablets Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature].Manufactured by: Eatontown, NJ 07724Revised September 2009Hydroxychloroquine Sulfate Tablets are White, Round Tablets; Embossed "WW28". Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base).    Bottles of 100 tablets Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature].Manufactured by: Eatontown, NJ 07724Revised September 2009


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
Use of this drug is contraindicated (1) in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, (2) in patients with known hypersensitivity to 4-aminoquinoline compounds, and (3) for long-term therapy in children.

Hydroxychloroquine Sulfate Tablets are not effective against chloroquine-resistant strains of .

Children are especially sensitive to the 4-aminoquinoline compounds. A number of fatalities have been reported following the accidental ingestion of chloroquine, sometimes in relatively small doses (0.75 g or 1 g in one 3-year-old child). Patients should be strongly warned to keep these drugs out of the reach of children.

Use of Hydroxychloroquine Sulfate Tablets in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. The preparation should not be used in these conditions unless in the judgment of the physician the benefit to the patient outweighs the possible hazard.

See and for interaction with CNS drugs and alcohol.

Methocarbamol may inhibit the effect of pyridostigmine bromide. Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents.

Antimalarial compounds should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Periodic blood cell counts should be made if patients are given prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuation of the drug should be considered. The drug should be administered with caution in patients having G-6-PD (glucose-6-phosphate dehydrogenase) deficiency.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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