Hyrdomorphone Hydrochloride

×

Overview

What is Hyrdomorphone Hydrochloride?

Hydromorphone Hydrochloride, a hydrogenated ketone of morphine, is an opioid agonist.

Hydromorphone Hydrochloride Tablets are supplied as 8 mg tablets for oral administration. The tablet strength describes the amount of hydromorphone hydrochloride in each tablet.

The chemical name is 4,5α-epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride. The Molecular Weight is 321.80. Its molecular formula is CHNO∙HCl, and it has the following chemical structure:

Hydromorphone hydrochloride is a white or almost white crystalline powder that is freely soluble in water, very slightly soluble in ethanol (96%), and practically insoluble in methylene chloride.

Each tablet for oral administration contains 8 mg hydromorphone hydrochloride. In addition, the tablets contain the following inactive ingredients: lactose anhydrous, magnesium stearate, microcrystalline cellulose and silicon dioxide.

What does Hyrdomorphone Hydrochloride look like?

What are the available doses of Hyrdomorphone Hydrochloride?

Hydromorphone Hydrochloride Tablets, USP 8 mg are white to off white, bisected triangular tablets debossed with "EL 14" on the bisected side.

What should I talk to my health care provider before I take Hyrdomorphone Hydrochloride?

How should I use Hyrdomorphone Hydrochloride?

Hydromorphone Hydrochloride Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse. ()

Usual adult starting dose for Hydromorphone Hydrochloride Tablets, USP is 8 mg every 12 hours. Appropriate use of Hydromorphone Hydrochloride Tablets must be decided by careful evaluation of each clinical situation. ()

Hepatic Impairment:

Renal Impairment:

Do not stop Hydromorphone Hydrochloride Tablets, USP abruptly in a physically-dependent patient. ()

What interacts with Hyrdomorphone Hydrochloride?

Sorry No Records found

What are the warnings of Hyrdomorphone Hydrochloride?

Sorry No Records found

What are the precautions of Hyrdomorphone Hydrochloride?

Sorry No Records found

What are the side effects of Hyrdomorphone Hydrochloride?

Sorry No records found

What should I look out for while using Hyrdomorphone Hydrochloride?

Hydromorphone Hydrochloride Tablets, USP are contraindicated in patients with:

What might happen if I take too much Hyrdomorphone Hydrochloride?

How should I store and handle Hyrdomorphone Hydrochloride?

SUSTIVA capsules and SUSTIVA tablets should be stored at 25°C (77°F); excursions permitted to 15°C-30°C (59°F-86°F) [see USP Controlled Room Temperature].Protect from light.Hydromorphone Hydrochloride Tablets, USP 8 mg are white to off white, bisected, triangular tablets debossed with "EL 14" on the bisected side. They are available as follows:NDC 68094-852-61Unit Dose Packages of 100 Tablets (10×10) per cartonProtect from light.Hydromorphone Hydrochloride Tablets, USP 8 mg are white to off white, bisected, triangular tablets debossed with "EL 14" on the bisected side. They are available as follows:NDC 68094-852-61Unit Dose Packages of 100 Tablets (10×10) per cartonProtect from light.Hydromorphone Hydrochloride Tablets, USP 8 mg are white to off white, bisected, triangular tablets debossed with "EL 14" on the bisected side. They are available as follows:NDC 68094-852-61Unit Dose Packages of 100 Tablets (10×10) per cartonProtect from light.Hydromorphone Hydrochloride Tablets, USP 8 mg are white to off white, bisected, triangular tablets debossed with "EL 14" on the bisected side. They are available as follows:NDC 68094-852-61Unit Dose Packages of 100 Tablets (10×10) per carton

×

Clinical Information

Chemical Structure

No Image found

Clinical Pharmacology

Hydromorphone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of hydromorphone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with morphine. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression.

The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug.

Non-Clinical Toxicology

Hydromorphone Hydrochloride Tablets, USP are contraindicated in patients with:

The concurrent administration of allopurinol and ampicillin increases substantially the incidence of skin rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.

Hydromorphone Hydrochloride Tablets, USP contain hydromorphone, a Schedule II controlled substance. As an opioid, Hydromorphone Hydrochloride exposes users to the risks of addiction, abuse, and misuse

Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Hydromorphone Hydrochloride Tablets, USP. Addiction can occur at recommended dosages and if the drug is misused or abused.

Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing Hydromorphone Hydrochloride Tablets, USP, and monitor all patients receiving Hydromorphone Hydrochloride Tablets, USP for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as Hydromorphone Hydrochloride Tablets, USP, but use in such patients necessitates intensive counseling about the risks and proper use of Hydromorphone Hydrochloride Tablets, USP along with intensive monitoring for signs of addiction, abuse, and misuse.

Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing Hydromorphone Hydrochloride Tablets, USP. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.

The following serious adverse reactions are described, or described in greater detail, in other sections:

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

×

Tips

×

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

Disclaimer: