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ibandronate sodium

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Overview

What is ibandronate sodium?

Ibandronate sodium is a nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption. The chemical name for ibandronate sodium is 3-(-methyl--pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate with the molecular formula CHNOPNa•HO and a molecular weight of 359.24. Ibandronate sodium is a white- to off-white powder. It is freely soluble in water and practically insoluble in organic solvents. Ibandronate sodium has the following structural formula:

Ibandronate sodium injection is intended for intravenous administration only. Ibandronate sodium injection is available as a sterile, clear, colorless, ready-to-use solution in a prefilled syringe that delivers 3.375 mg of ibandronate monosodium salt monohydrate in 3 mL of solution, equivalent to a dose of 3 mg ibandronate free acid. Inactive ingredients include sodium chloride, glacial acetic acid, sodium acetate and water.



What does ibandronate sodium look like?



What are the available doses of ibandronate sodium?

Ibandronate sodium injection is supplied as a kit containing:

What should I talk to my health care provider before I take ibandronate sodium?

How should I use ibandronate sodium?

Ibandronate sodium injection is indicated for the treatment of osteoporosis in postmenopausal women. In postmenopausal women with osteoporosis, ibandronate sodium injection increases bone mineral density (BMD) and reduces the incidence of vertebral fractures .

Ibandronate sodium injection must be administered intravenously only by a health care professional. Care must be taken not to administer intra-arterially or paravenously as this could lead to tissue damage


What interacts with ibandronate sodium?

Sorry No Records found


What are the warnings of ibandronate sodium?

Sorry No Records found


What are the precautions of ibandronate sodium?

Sorry No Records found


What are the side effects of ibandronate sodium?

Sorry No records found


What should I look out for while using ibandronate sodium?

Ibandronate is contraindicated in patients with the following conditions:


What might happen if I take too much ibandronate sodium?

No cases of overdose were reported in premarketing studies with ibandronate injection. Overdosage with intravenous bisphosphonates may result in hypocalcemia, hypophosphatemia, and hypomagnesemia. Clinically relevant reductions in serum levels of calcium, phosphorus, and magnesium should be corrected by intravenous administration of calcium gluconate, potassium or sodium phosphate, and magnesium sulfate, respectively.

Dialysis would not be beneficial unless it is administered within 2 hours following the overdose.


How should I store and handle ibandronate sodium?

Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The action of ibandronate on bone is based on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Non-Clinical Toxicology
Ibandronate is contraindicated in patients with the following conditions:

Ibandronate injection may cause a decrease in serum calcium values. Treat hypocalcemia, hypovitaminosis D, and other disturbances of bone and mineral metabolism before starting ibandronate injection therapy.

Adequate intake of calcium and vitamin D is important in all patients. It is recommended that patients receive supplemental calcium and vitamin D if dietary intake is inadequate.

Adverse reactions that appear in other sections of the labeling include:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).