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INDERAL

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Overview

What is INDERAL?

Inderal (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent chemically described as 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride,(±)-. Its molecular and structural formulae are:

CHNO · HCl

Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.

Inderal LA is formulated to provide a sustained release of propranolol hydrochloride. Inderal LA is available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration.

The inactive ingredients contained in Inderal LA capsules are: microcrystalline cellulose, ethylcellulose, gelatin capsules, hypromellose, and titanium dioxide. In addition, Inderal LA 60 mg, 80 mg, and 120 mg capsules contain D&C Red No. 28 and FD&C Blue No. 1; Inderal LA 160 mg capsules contain FD&C Blue No. 1.

These capsules comply with USP Dissolution Test 1.



What does INDERAL look like?



What are the available doses of INDERAL?

Sorry No records found.

What should I talk to my health care provider before I take INDERAL?

Sorry No records found

How should I use INDERAL?

Hypertension

Inderal LA is indicated in the management of hypertension. It may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Inderal LA is not indicated in the management of hypertensive emergencies.

General

Inderal LA provides propranolol hydrochloride in a sustained-release capsule for administration once daily. If patients are switched from Inderal Tablets to Inderal LA Capsules, care should be taken to assure that the desired therapeutic effect is maintained. Inderal LA should not be considered a simple mg-for-mg substitute for Inderal. Inderal LA has different kinetics and produces lower blood levels. Retitration may be necessary, especially to maintain effectiveness at the end of the 24-hour dosing interval.


What interacts with INDERAL?

Sorry No Records found


What are the warnings of INDERAL?

Sorry No Records found


What are the precautions of INDERAL?

Sorry No Records found


What are the side effects of INDERAL?

Sorry No records found


What should I look out for while using INDERAL?

Propranolol is contraindicated in 1) cardiogenic shock; 2) sinus bradycardia and greater than first-degree block; 3) bronchial asthma; and 4) in patients with known hypersensitivity to propranolol hydrochloride.


What might happen if I take too much INDERAL?

Propranolol is not significantly dialyzable. In the event of overdosage or exaggerated response, the following measures should be employed:

General:

Supportive Therapy:

The electrocardiogram, pulse, blood pressure, neurobehavioral status and intake and output balance must be monitored. Isoproterenol and aminophylline may be used for bronchospasm.


How should I store and handle INDERAL?

Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16Inderal LA (propranolol hydrochloride) Long-Acting CapsulesEach white/light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 60’, contains 60 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-520-01).Each light-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 80’, contains 80 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-521-01).Each light-blue/dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 120’, contains 120 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-522-01).Each dark-blue capsule, imprinted with three rings and reverse imprinted ‘INDERAL LA 160’, contains 160 mg of propranolol hydrochloride in bottles of 100 (NDC 62559-523-01).Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]Protect from light, moisture, freezing, and excessive heat.Dispense in a tight, light-resistant container as defined in the USP.Manufactured by:Pfizer Ireland PharmaceuticalsLittle Connell, Newbridge, Co. Kildare, IrelandDistributed by:ANI Pharmaceuticals, Inc.Baudette, MN 56623 For Medical Inquires, call toll-free at 1-800-308-6755.PAA0772299909 Rev 10/16


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

General

Propranolol is a nonselective, beta-adrenergic receptor-blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor-stimulating agents for available receptor sites. When access to beta-receptor sites is blocked by propranolol, the chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportionately. At dosages greater than required for beta blockade, propranolol also exerts a quinidine-like or anesthetic-like membrane action, which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain.

Inderal LA should not be considered a simple mg-for-mg substitute for conventional propranolol and the blood levels achieved do not match (are lower than) those of two to four times daily dosing with the same dose (see ). When changing to Inderal LA from conventional propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval. In most clinical settings, however, such as hypertension or angina where there is little correlation between plasma levels and clinical effect, Inderal LA has been therapeutically equivalent to the same mg dose of conventional Inderal as assessed by 24-hour effects on blood pressure and on 24-hour exercise responses of heart rate, systolic pressure, and rate pressure product.

Non-Clinical Toxicology
Propranolol is contraindicated in 1) cardiogenic shock; 2) sinus bradycardia and greater than first-degree block; 3) bronchial asthma; and 4) in patients with known hypersensitivity to propranolol hydrochloride.

Drug Interactions

Caution should be exercised when Inderal LA is administered with drugs that have an affect on CYP2D6, 1A2, or 2C19 metabolic pathways. Co-administration of such drugs with propranolol may lead to clinically relevant drug interactions and changes on its efficacy and/or toxicity (see in ).

Alcohol

Cardiovascular Drugs

Antiarrhythmics

Propafenone has negative inotropic and beta-blocking properties that can be additive to those of propranolol.

Quinidine increases the concentration of propranolol and produces greater degrees of clinical beta-blockade and may cause postural hypotension.

Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with β-blockers such as propranolol.

The clearance of lidocaine is reduced with administration of propranolol. Lidocaine toxicity has been reported following co-administration with propranolol.

Caution should be exercised when administering Inderal LA with drugs that slow A-V nodal conduction, e.g., lidocaine and calcium channel blockers.

Digitalis Glycosides

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.

Calcium Channel Blockers

Caution should be exercised when patients receiving a beta-blocker are administered a calcium-channel-blocking drug with negative inotropic and/or chronotropic effects. Both agents may depress myocardial contractility or atrioventricular conduction.

There have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.

Co-administration of propranolol and diltiazem in patients with cardiac disease has been associated with bradycardia, hypotension, high degree heart block, and heart failure.

ACE Inhibitors

When combined with beta-blockers, ACE inhibitors can cause hypotension, particularly in the setting of acute myocardial infarction.

The antihypertensive effects of clonidine may be antagonized by beta-blockers. Inderal LA should be administered cautiously to patients withdrawing from clonidine.

Alpha Blockers

Prazosin has been associated with prolongation of first dose hypotension in the presence of beta-blockers.

Postural hypotension has been reported in patients taking both beta-blockers and terazosin or doxazosin.

Reserpine

Patients receiving catecholamine-depleting drugs, such as reserpine should be closely observed for excessive reduction of resting sympathetic nervous activity, which may result in hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.

Inotropic Agents

Patients on long-term therapy with propranolol may experience uncontrolled hypertension if administered epinephrine as a consequence of unopposed alpha-receptor stimulation. Epinephrine is therefore not indicated in the treatment of propranolol overdose (see ).

Isoproterenol and Dobutamine

Propranolol is a competitive inhibitor of beta-receptor agonists, and its effects can be reversed by administration of such agents, e.g., dobutamine or isoproterenol. Also, propranolol may reduce sensitivity to dobutamine stress echocardiography in patients undergoing evaluation for myocardial ischemia.

Non-Cardiovascular Drugs

Nonsteroidal Anti-Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to blunt the antihypertensive effect of beta-adrenoreceptor blocking agents.

Administration of indomethacin with propranolol may reduce the efficacy of propranolol in reducing blood pressure and heart rate.

Antidepressants

The hypotensive effects of MAO inhibitors or tricyclic antidepressants may be exacerbated when administered with beta-blockers by interfering with the beta blocking activity of propranolol.

Anesthetic Agents

Methoxyflurane and trichloroethylene may depress myocardial contractility when administered with propranolol.

Warfarin

Propranolol when administered with warfarin increases the concentration of warfarin. Prothrombin time, therefore, should be monitored.

Neuroleptic Drugs

Hypotension and cardiac arrest have been reported with the concomitant use of propranolol and haloperidol.

Thyroxine

Thyroxine may result in a lower than expected T concentration when used concomitantly with propranolol.

General

Propranolol should be used with caution in patients with impaired hepatic or renal function. Inderal LA is not indicated for the treatment of hypertensive emergencies.

Beta-adrenergic receptor blockade can cause reduction of intraocular pressure. Patients should be told that Inderal LA may interfere with the glaucoma screening test. Withdrawal may lead to a return of increased intraocular pressure.

While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.

The following adverse events were observed and have been reported in patients using propranolol.

Cardiovascular:

Central Nervous System:

Gastrointestinal:

Allergic:

Respiratory:

Hematologic:

Autoimmune:

Skin and mucous membranes:

Genitourinary:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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