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INGREZZA

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Overview

What is INGREZZA?

INGREZZA contains valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor, present as valbenazine tosylate salt, with the chemical name, L-Valine, (,11b)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2-benzo[]quinolizin-2-yl ester, 4-methylbenzenesulfonate (1:2). Valbenazine tosylate is slightly soluble in water. Its molecular formula is CHNOS, and its molecular weight is 762.97 g/mol (ditosylate salt) with the following structure:

The molecular formula of valbenazine free base is CHNOand its molecular weight is 418.57.

INGREZZA capsules are intended for oral administration only. Each capsule contains valbenazine tosylate equivalent to 40 or 80 mg of valbenazine free base. The 40 mg capsules contain the following inactive ingredients: mannitol, partially pregelatinized starch, fumed silica, and magnesium stearate. The 80 mg capsules contain the following inactive ingredients: silicified microcrystalline cellulose, isomalt, partially pregelatinized starch, hypromellose, and magnesium stearate. The capsule shells contain gelatin, candurin silver fine, FD&C Red#40, and FD&C Blue#1.



What does INGREZZA look like?



What are the available doses of INGREZZA?

Capsules: 40 mg and 80 mg. ()       

What should I talk to my health care provider before I take INGREZZA?

                 

                       

How should I use INGREZZA?

INGREZZA is indicated for the treatment of adults with tardive dyskinesia  

The initial dose for INGREZZA is 40 mg once daily. After one week, increase the dose to the recommended dose of 80 mg once daily. Continuation of 40 mg once daily may be considered for some patients.

Administer INGREZZA orally with or without food


What interacts with INGREZZA?

Sorry No Records found


What are the warnings of INGREZZA?

Sorry No Records found


What are the precautions of INGREZZA?

Sorry No Records found


What are the side effects of INGREZZA?

Sorry No records found


What should I look out for while using INGREZZA?

None.


What might happen if I take too much INGREZZA?


How should I store and handle INGREZZA?

StorageStore in a well-closed container at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) [see USP Controlled Room Temperature].StorageStore in a well-closed container at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) [see USP Controlled Room Temperature].INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.INGREZZA (valbenazine) capsules are available as:40 mg Capsule: Bottle of 30: NDC 70370-1040-1Bottle of 90: NDC 70370-1040-280 mg Capsule: Bottle of 30: NDC 70370-1080-1StorageStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). See USP Controlled Room Temperature.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Non-Clinical Toxicology
None.

INGREZZA can cause somnolence. Patients should not perform activities requiring mental alertness such as operating a motor vehicle or operating hazardous machinery until they know how they will be affected by INGREZZA

The following adverse reactions are discussed in more detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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