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INVOKAMET XR

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Overview

What is INVOKAMET XR?

INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: canagliflozin and metformin hydrochloride.



What does INVOKAMET XR look like?



What are the available doses of INVOKAMET XR?

Film-coated tablets:

What should I talk to my health care provider before I take INVOKAMET XR?

How should I use INVOKAMET XR?

INVOKAMET XR (canagliflozin and metformin hydrochloride extended release) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both canagliflozin and metformin is appropriate.

Individualize based on the patient's current regimen ()

Take two tablets once daily with the morning meal ()

In patients currently not treated with either canagliflozin or metformin, initiate therapy with two INVOKAMET XR tablets, each tablet containing canagliflozin 50 mg and metformin 500 mg ()

In patients already treated with canagliflozin and metformin, switch to two INVOKAMET XR tablets containing the same total daily dose of canagliflozin and the same, or nearest appropriate, total daily dose of metformin ()

In patients that require additional glycemic control that are taking a total daily dose of canagliflozin 100 mg, the INVOKAMET XR dose can be increased to canagliflozin 300 mg once daily. Do not exceed a total daily canagliflozin dose of 300 mg ()

Gradually escalate metformin dose to reduce the gastrointestinal side effects while not exceeding a total daily dose of 2000 mg ()

Assess renal function before initiating and periodically thereafter ()

INVOKAMET XR is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 45 mL/min/1.73 m()

Limit the dose of canagliflozin component to two tablets, each tablet containing 50 mg, daily in patients with an eGFR of 45 to less than 60 mL/min/1.73 m()

INVOKAMET XR may need to be discontinued at time of, or prior to, iodinated contrast imaging procedures ()

Swallow whole. Never crush, cut, or chew ()


What interacts with INVOKAMET XR?

Sorry No Records found


What are the warnings of INVOKAMET XR?

Sorry No Records found


What are the precautions of INVOKAMET XR?

Sorry No Records found


What are the side effects of INVOKAMET XR?

Sorry No records found


What should I look out for while using INVOKAMET XR?

INVOKAMET XR is contraindicated in patients with:


What might happen if I take too much INVOKAMET XR?

In the event of an overdose with INVOKAMET XR, contact the Poison Control Center. Employ the usual supportive measures (e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive treatment) as dictated by the patient's clinical status. Canagliflozin was negligibly removed during a 4-hour hemodialysis session. Canagliflozin is not expected to be dialyzable by peritoneal dialysis. Metformin is dialyzable with a clearance of up to 170 mL/min under good hemodynamic conditions. Therefore, hemodialysis may be useful partly for removal of accumulated metformin from patients in whom INVOKAMET XR overdosage is suspected.


How should I store and handle INVOKAMET XR?

Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.INVOKAMET XR (canagliflozin and metformin hydrochloride extended-release) tablets are available in the strengths and packages listed below:Canagliflozin 50 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, almost white to light orange film-coated tablets with "CM1" on one side. A thin line on the tablet side may be visible.Canagliflozin 50 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, pink film-coated tablets with "CM3" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 500 mg extended-release tablets are oblong, biconvex, orange, film-coated tablets with "CM2" on one side. A thin line on the tablet side may be visible.Canagliflozin 150 mg and metformin hydrochloride 1,000 mg extended-release tablets are oblong, biconvex, reddish brown, film-coated tablets with "CM4" on one side. A thin line on the tablet side may be visible.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Non-Clinical Toxicology
INVOKAMET XR is contraindicated in patients with:

There have been post-marketing cases of metformin-associated lactic acidosis, including fatal cases. These cases had a subtle onset and were accompanied by nonspecific symptoms such as malaise, myalgias, abdominal pain, respiratory distress, or increased somnolence; however, hypothermia, hypotension and resistant bradyarrhythmias have occurred with severe acidosis. Metformin-associated lactic acidosis was characterized by elevated blood lactate concentrations (>5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), and an increased lactate:pyruvate ratio; metformin plasma levels generally >5 mcg/mL. Metformin decreases liver uptake of lactate increasing lactate blood levels which may increase the risk of lactic acidosis, especially in patients at risk.

If metformin-associated lactic acidosis is suspected, general supportive measures should be instituted promptly in a hospital setting, along with immediate discontinuation of INVOKAMET XR. In INVOKAMET XR-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin hydrochloride is dialyzable, with a clearance of up to 170 mL/minute under good hemodynamic conditions). Hemodialysis has often resulted in reversal of symptoms and recovery.

Educate patients and their families about the symptoms of lactic acidosis and if these symptoms occur instruct them to discontinue INVOKAMET XR and report these symptoms to their healthcare provider.

For each of the known and possible risk factors for metformin-associated lactic acidosis, recommendations to reduce the risk of and manage metformin-associated lactic acidosis are provided below:

The following adverse reactions are also discussed elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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